Short description
Tyson1991 - Cell Cycle 6 var

Mathematical model of the interactions of cdc2 and cyclin.

This model is described in the article:

Tyson JJ.
Proc. Natl. Acad. Sci. U.S.A. 1991; 88(16); 7328-32

Abstract:

The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Format
SBML (L2V4)
Related Publication
  • Modeling the cell division cycle: cdc2 and cyclin interactions.
  • Tyson JJ
  • Proceedings of the National Academy of Sciences of the United States of America , 8/ 1991 , Volume 88 , pages: 7328-7332
  • Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg 24061.
  • The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells.
Contributors
Nicolas Le Novère

Metadata information

is
BioModels Database MODEL6614644188
BioModels Database BIOMD0000000005
isDescribedBy
PubMed 1831270
hasTaxon
Taxonomy Homo sapiens
hasVersion
Curation status
Curated
  • Model originally submitted by : Nicolas Le Novère
  • Submitted: 13-Sep-2005 13:31:08
  • Last Modified: 16-May-2013 15:40:43
Revisions
  • Version: 2 public model Download this version
    • Submitted on: 16-May-2013 15:40:43
    • Submitted by: Nicolas Le Novère
    • With comment: Current version of Tyson1991 - Cell Cycle 6 var
  • Version: 1 public model Download this version
    • Submitted on: 13-Sep-2005 13:31:08
    • Submitted by: Nicolas Le Novère
    • With comment: Original import of Tyson1991_CellCycle_6var
Curator's comment:
(added: 08 Feb 2010, 10:29:04, updated: 08 Feb 2010, 10:29:04)
The model reproduces figure 3A of the reference publication. The model was integrated and simulated using Copasi v4.5 (Build 30).