Novak1997 - Cell Cycle

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Short description
Novak1997 - Cell Cycle

Modeling the control of DNA replication in fission yeast.

This model is described in the article:

Novak B., Tyson JJ.
Proc. Natl. Acad. Sci. U.S.A. 1997:94(17):9147-52

Abstract:

A central event in the eukaryotic cell cycle is the decision to commence DNA replication (S phase). Strict controls normally operate to prevent repeated rounds of DNA replication without intervening mitoses ("endoreplication") or initiation of mitosis before DNA is fully replicated ("mitotic catastrophe"). Some of the genetic interactions involved in these controls have recently been identified in yeast. From this evidence we propose a molecular mechanism of "Start" control in Schizosaccharomyces pombe. Using established principles of biochemical kinetics, we compare the properties of this model in detail with the observed behavior of various mutant strains of fission yeast: wee1(-) (size control at Start), cdc13Delta and rum1(OP) (endoreplication), and wee1(-) rum1Delta (rapid division cycles of diminishing cell size). We discuss essential features of the mechanism that are responsible for characteristic properties of Start control in fission yeast, to expose our proposal to crucial experimental tests.

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Format
SBML (L2V3)
Related Publication
  • Modeling the control of DNA replication in fission yeast.
  • Novak B, Tyson JJ
  • Proceedings of the National Academy of Sciences of the United States of America , 8/ 1997 , Volume 94 , pages: 9147-9152
  • Department of Agricultural Chemical Technology, Technical University of Budapest, 1521 Budapest, St. Gellert ter 4, Hungary.
  • A central event in the eukaryotic cell cycle is the decision to commence DNA replication (S phase). Strict controls normally operate to prevent repeated rounds of DNA replication without intervening mitoses ("endoreplication") or initiation of mitosis before DNA is fully replicated ("mitotic catastrophe"). Some of the genetic interactions involved in these controls have recently been identified in yeast. From this evidence we propose a molecular mechanism of "Start" control in Schizosaccharomyces pombe. Using established principles of biochemical kinetics, we compare the properties of this model in detail with the observed behavior of various mutant strains of fission yeast: wee1(-) (size control at Start), cdc13Delta and rum1(OP) (endoreplication), and wee1(-) rum1Delta (rapid division cycles of diminishing cell size). We discuss essential features of the mechanism that are responsible for characteristic properties of Start control in fission yeast, to expose our proposal to crucial experimental tests.
Contributors
Nicolas Le Novère

Metadata information

is
BioModels Database MODEL6614787694
BioModels Database BIOMD0000000007
isDescribedBy
PubMed 9256450
isDerivedFrom
PubMed 10395816
isVersionOf
Gene Ontology mitotic cell cycle
KEGG Pathway Cell cycle
isHomologTo
Curation status
Curated
  • Model originally submitted by : Nicolas Le Novère
  • Submitted: Sep 13, 2005 1:33:30 PM
  • Last Modified: Mar 26, 2014 2:20:21 PM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Mar 26, 2014 2:20:21 PM
    • Submitted by: Nicolas Le Novère
    • With comment: Current version of Novak1997 - Cell Cycle
  • Version: 1 public model Download this version
    • Submitted on: Sep 13, 2005 1:33:30 PM
    • Submitted by: Nicolas Le Novère
    • With comment: Original import of Novak1997_CellCycle
Curator's comment:
(added: 15 Oct 2009, 16:25:07, updated: 15 Oct 2009, 16:25:07)
The figure corresponds to figure 2A of the original puplication. The plots in the paper were not reproduced by the model as such, but this is the best we were able to get from the parameters used in the paper without initial conditions. The model was simulated using Mathematica 6.0 - MathSBML 2.7.1.