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  • A model for circadian oscillations in the Drosophila period protein (PER).
  • Goldbeter A
  • Proceedings. Biological sciences , 9/ 1995 , Volume 261 , pages: 319-324
  • Faculté des Sciences, Université Libre de Bruxelles, Brussels, Belgium.
  • The mechanism of circadian oscillations in the period protein (PER) in Drosophila is investigated by means of a theoretical model. Taking into account recent experimental observations, the model for the circadian clock is based on multiple phosphorylation of PER and on the negative feedback exerted by PER on the transcription of the period (per) gene. This minimal biochemical model provides a molecular basis for circadian oscillations of the limit cycle type. During oscillations, the peak in per mRNA precedes by several hours the peak in total PER protein. The results support the view that multiple PER phosphorylation introduces times delays which strengthen the capability of negative feedback to produce oscillations. The analysis shows that the rhythm only occurs in a range bounded by two critical values of the maximum rate of PER degradation. A similar result is obtained with respect to the rate of PER transport into the nucleus. The results suggest a tentative explanation for the altered period of per mutants, in terms of variations in the rate of PER degradation.
Nicolas Le Novère

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BIOMD0000000016.xml.origin SBML L2V1 representation of Goldbeter1995_CircClock 24.22 KB Preview | Download

  • Model originally submitted by : Nicolas Le Novère
  • Submitted: Sep 13, 2005 2:13:05 PM
  • Last Modified: Feb 25, 2015 1:08:26 PM
  • Version: 2 public model Download this version
    • Submitted on: Feb 25, 2015 1:08:26 PM
    • Submitted by: Nicolas Le Novère
    • With comment: Current version of Goldbeter1995_CircClock
  • Version: 1 public model Download this version
    • Submitted on: Sep 13, 2005 2:13:05 PM
    • Submitted by: Nicolas Le Novère
    • With comment: Original import of Goldbeter1995_CircClock
Curator's comment:
(added: 06 Aug 2007, 13:20:48, updated: 06 Aug 2007, 13:20:48)
Figure 2 reproduced with COPASI 4.1 (build 21)