public model
Short description

Bruce Shapiro: Generated by Cellerator Version 1.0 update 3.0303 using Mathematica 4.1 for Microsoft Windows (June 13, 2001), April 2, 2003 16:49:13, using (PC,x86, Microsoft Windows,WindowsNT,Windows)

Bruce Shapiro: Corrected 29 March 2005

Nicolas Le Novère: Added Dbt and Cyc species, and the corresponding reactions. 23 April 2005

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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Related Publication
  • Robust oscillations within the interlocked feedback model of Drosophila circadian rhythm.
  • Ueda HR, Hagiwara M, Kitano H
  • Journal of theoretical biology , 6/ 2001 , Volume 210 , pages: 401-406
  • ERATO Kitano Symbiotic Systems Group, Suite 6A, M31, 6-31-15 Jinguumae, Shibuya, Tokyo, 150-0001, Japan. hiro@m.u-tokyo.ac.jp
  • A mechanism for generating circadian rhythms has been of major interest in recent years. After the discovery of per and tim, a model with a simple feedback loop involving per and tim has been proposed. However, it is recognized that the simple feedback model cannot account for phenotypes generated by various mutants. A recent report by Glossop, Lyons & Hardin [Science286, 766 (1999)] on Drosophila suggests involvement of another feedback loop by dClk that is interlocked with per-tim feedback loop. In order to examine whether interlocked feedback loops can be a basic mechanism for circadian rhythms, a mathematical model was created and examined. Through extensive simulation and mathematical analysis, it was revealed that the interlocked feedback model accounts for the observations that are not explained by the simple feedback model. Moreover, the interlocked feedback model has robust properties in oscillations.
Nicolas Le Novère

Metadata information

BioModels Database MODEL6617909980
BioModels Database BIOMD0000000022
PubMed 11403560
PubMed 10531060
KEGG Pathway dme04710
Gene Ontology regulation of circadian rhythm
Curation status
Name Description Size Actions

Model files

BIOMD0000000022_url.xml SBML L2V1 representation of Ueda2001_CircClock 64.52 KB Preview | Download

Additional files

BIOMD0000000022.m Auto-generated Octave file 15.47 KB Preview | Download
BIOMD0000000022_urn.xml Auto-generated SBML file with URNs 63.27 KB Preview | Download
BIOMD0000000022-biopax2.owl Auto-generated BioPAX (Level 2) 43.92 KB Preview | Download
BIOMD0000000022.xpp Auto-generated XPP file 9.77 KB Preview | Download
BIOMD0000000022.svg Auto-generated Reaction graph (SVG) 72.82 KB Preview | Download
BIOMD0000000022.png Auto-generated Reaction graph (PNG) 154.07 KB Preview | Download
BIOMD0000000022.vcml Auto-generated VCML file 897.00 bytes Preview | Download
BIOMD0000000022-biopax3.owl Auto-generated BioPAX (Level 3) 71.63 KB Preview | Download
BIOMD0000000022.pdf Auto-generated PDF file 272.79 KB Preview | Download
BIOMD0000000022.sci Auto-generated Scilab file 10.76 KB Preview | Download

  • Model originally submitted by : Nicolas Le Novère
  • Submitted: Sep 13, 2005 2:25:30 PM
  • Last Modified: Feb 25, 2015 12:55:44 PM
  • Version: 2 public model Download this version
    • Submitted on: Feb 25, 2015 12:55:44 PM
    • Submitted by: Nicolas Le Novère
    • With comment: Current version of Ueda2001_CircClock
  • Version: 1 public model Download this version
    • Submitted on: Sep 13, 2005 2:25:30 PM
    • Submitted by: Nicolas Le Novère
    • With comment: Original import of BIOMD0000000022.xml.origin
Curator's comment:
(added: 19 Oct 2006, 22:05:48, updated: 19 Oct 2006, 22:05:48)
Figure 3d reproduced by COPASI 4 build 19