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BIOMD0000000070 - Holzhutter2004_Erythrocyte_Metabolism

 

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Reference Publication
Publication ID: 15233787
Holzhütter HG.
The principle of flux minimization and its application to estimate stationary fluxes in metabolic networks.
Eur. J. Biochem. 2004 Jul; 271(14): 2905-2922
Humboldt-University Berlin, Medical School (Charité), Institute of Biochemistry, Berlin, Germany. hermann-georg.holzhuetter@charite.de  [more]
Model
Original Model: JWS logo
Submitter: Nicolas Le Novère
Submission ID: MODEL6624180840
Submission Date: 22 Sep 2006 19:01:01 UTC
Last Modification Date: 08 Apr 2016 16:29:23 UTC
Creation Date: 07 Sep 2006 16:04:38 UTC
Encoders:  Jacky L Snoep
   Harish Dharuri
set #1
bqbiol:hasPart Reactome REACT_1859
Reactome REACT_2220
Reactome REACT_1383
set #2
bqbiol:hasTaxon Taxonomy Homo sapiens
set #3
bqbiol:hasPart KEGG Pathway Glutathione metabolism - Homo sapiens (human)
KEGG Pathway Pentose phosphate pathway - Homo sapiens (human)
KEGG Pathway Glycolysis / Gluconeogenesis - Homo sapiens (human)
set #4
bqbiol:hasPart Gene Ontology glutathione metabolic process
Gene Ontology pentose-phosphate shunt
Gene Ontology glycolytic process
Notes

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SBML level 2 code generated for the JWS Online project by Jacky Snoep using PySCeS
Run this model online at http://jjj.biochem.sun.ac.za
To cite JWS Online please refer to: Olivier, B.G. and Snoep, J.L. (2004) Web-based modelling using JWS Online, Bioinformatics, 20:2143-2144

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Biomodels Curation The model simulates the flux values as given for "kinetic model" in Table 1 of the paper. The model was successfully tested on Jarnac.

Model
Publication ID: 15233787 Submission Date: 22 Sep 2006 19:01:01 UTC Last Modification Date: 08 Apr 2016 16:29:23 UTC Creation Date: 07 Sep 2006 16:04:38 UTC
Mathematical expressions
Reactions
Glucose transport Hexokinase Glucosephosphate isomerase Phosphofructokinase
Aldolase Triosephosphate isomerase Glyceraldehyde 3-phosphate dehydrogenase Phosphoglycerate kinase
Bisphosphoglycerate mutase Bisphosphoglycerate phosphatase Phosphoglycerate mutase Enolase
Pyruvate kinase Lactate dehydrogenase Lactate dehydrogenase ATPase
Adenylate kinase Glucose 6-phosphate dehydrogenase Phosphogluconate dehydrogenase Glutathione reductase
Glutathione oxidation Phosphoribulose epimerase Ribose phosphate isomerase Transketolase 1
Transaldolase Phosphoribosylpyrophosphate synthetase Transketolase 2 Phosphate exchange
Lactate exchange Pyruvate exchange MgATP dissociation MgADP dissociation
MgAMP dissociation MgGri23P2 dissociation P1NADP dissociation P1NADPH dissociation
P2NADP dissociation P2NADPH dissociation    
Physical entities
Compartments Species
cytoplasm Glucose in MgATP Glucose 6-phosphate
MgADP Fructose 6-phosphate Fructose 1,6-phosphate
Glyceraldehyde 3-phosphate Dihydroxyacetone phosphate Phosphate
NAD 1,3-Bisphospho-D-glycerate NADH
3-Phospho-D-glycerate 2,3-Bisphospho-D-glycerate 2-Phospho-D-glycerate
Phosphoenolpyruvate Pyruvate Lactate
NADPH NADP AMP
ADP Phospho-D-glucono-1,5-lactone Ribulose 5-phosphate
Oxidized Glutathione Reduced Glutathione Xylulose 5-phosphate
Ribose 5-phosphate Sedoheptulose 7-phosphate Erythrose 4-phosphate
MgAMP ATP Mg
MgGri23P2 Protein1 bound NADP Protein1
Protein1 bound NADPH Protein2 bound NADP Protein2
Protein2 bound NADPH PRPP External Lactate
External Pyruvate Glucose outside Phosphate external
Reactions (38)
 
 Glucose transport [Glucose outside] ↔ [Glucose in];  
 
 Hexokinase [Glucose in] + [MgATP] ↔ [Glucose 6-phosphate] + [MgADP];   {Mg} , {2,3-Bisphospho-D-glycerate} , {MgGri23P2}
 
 Glucosephosphate isomerase [Glucose 6-phosphate] ↔ [Fructose 6-phosphate];  
 
 Phosphofructokinase [MgATP] + [Fructose 6-phosphate] ↔ [Fructose 1,6-phosphate] + [MgADP];   {ATP} , {Mg} , {AMP} , {MgAMP}
 
 Aldolase [Fructose 1,6-phosphate] ↔ [Glyceraldehyde 3-phosphate] + [Dihydroxyacetone phosphate];  
 
 Triosephosphate isomerase [Dihydroxyacetone phosphate] ↔ [Glyceraldehyde 3-phosphate];  
 
 Glyceraldehyde 3-phosphate dehydrogenase [Glyceraldehyde 3-phosphate] + [Phosphate] + [NAD] ↔ [NADH] + [1,3-Bisphospho-D-glycerate];  
 
 Phosphoglycerate kinase [MgADP] + [1,3-Bisphospho-D-glycerate] ↔ [MgATP] + [3-Phospho-D-glycerate];  
 
 Bisphosphoglycerate mutase [1,3-Bisphospho-D-glycerate] ↔ [2,3-Bisphospho-D-glycerate];   {MgGri23P2}
 
 Bisphosphoglycerate phosphatase [2,3-Bisphospho-D-glycerate] ↔ [3-Phospho-D-glycerate] + [Phosphate];   {MgGri23P2}
 
 Phosphoglycerate mutase [3-Phospho-D-glycerate] ↔ [2-Phospho-D-glycerate];  
 
 Enolase [2-Phospho-D-glycerate] ↔ [Phosphoenolpyruvate];  
 
 Pyruvate kinase [Phosphoenolpyruvate] + [MgADP] ↔ [MgATP] + [Pyruvate];   {ATP} , {Fructose 1,6-phosphate}
 
 Lactate dehydrogenase [NADH] + [Pyruvate] ↔ [Lactate] + [NAD];  
 
 Lactate dehydrogenase [Pyruvate] + [NADPH] ↔ [Lactate] + [NADP];  
 
 ATPase [MgATP] ↔ [Phosphate] + [MgADP];  
 
 Adenylate kinase [MgATP] + [AMP] ↔ [ADP] + [MgADP];  
 
 Glucose 6-phosphate dehydrogenase [Glucose 6-phosphate] + [NADP] ↔ [Phospho-D-glucono-1,5-lactone] + [NADPH];   {ATP} , {MgATP} , {2,3-Bisphospho-D-glycerate} , {MgGri23P2}
 
 Phosphogluconate dehydrogenase [Phospho-D-glucono-1,5-lactone] + [NADP] ↔ [Ribulose 5-phosphate] + [NADPH];   {2,3-Bisphospho-D-glycerate} , {MgGri23P2} , {ATP} , {MgATP}
 
 Glutathione reductase [Oxidized Glutathione] + [NADPH] ↔ 2.0 × [Reduced Glutathione] + [NADP];  
 
 Glutathione oxidation 2.0 × [Reduced Glutathione] ↔ [Oxidized Glutathione];  
 
 Phosphoribulose epimerase [Ribulose 5-phosphate] ↔ [Xylulose 5-phosphate];  
 
 Ribose phosphate isomerase [Ribulose 5-phosphate] ↔ [Ribose 5-phosphate];  
 
 Transketolase 1 [Xylulose 5-phosphate] + [Ribose 5-phosphate] ↔ [Glyceraldehyde 3-phosphate] + [Sedoheptulose 7-phosphate];  
 
 Transaldolase [Glyceraldehyde 3-phosphate] + [Sedoheptulose 7-phosphate] ↔ [Erythrose 4-phosphate] + [Fructose 6-phosphate];  
 
 Phosphoribosylpyrophosphate synthetase [MgATP] + [Ribose 5-phosphate] ↔ [MgAMP] + [PRPP];  
 
 Transketolase 2 [Xylulose 5-phosphate] + [Erythrose 4-phosphate] ↔ [Glyceraldehyde 3-phosphate] + [Fructose 6-phosphate];  
 
 Phosphate exchange [Phosphate external] ↔ [Phosphate];  
 
 Lactate exchange [External Lactate] ↔ [Lactate];  
 
 Pyruvate exchange [External Pyruvate] ↔ [Pyruvate];  
 
 MgATP dissociation [MgATP] ↔ [Mg] + [ATP];  
 
 MgADP dissociation [MgADP] ↔ [Mg] + [ADP];  
 
 MgAMP dissociation [MgAMP] ↔ [Mg] + [AMP];  
 
 MgGri23P2 dissociation [MgGri23P2] ↔ [Mg] + [2,3-Bisphospho-D-glycerate];  
 
 P1NADP dissociation [Protein1 bound NADP] ↔ [Protein1] + [NADP];  
 
 P1NADPH dissociation [Protein1 bound NADPH] ↔ [Protein1] + [NADPH];  
 
 P2NADP dissociation [Protein2 bound NADP] ↔ [Protein2] + [NADP];  
 
 P2NADPH dissociation [Protein2 bound NADPH] ↔ [Protein2] + [NADPH];  
 
 cytoplasm Spatial dimensions: 3.0  Compartment size: 1.0
 
 Glucose in
Compartment: cytoplasm
Initial concentration: 4.5663
 
 MgATP
Compartment: cytoplasm
Initial concentration: 1.4
 
 Glucose 6-phosphate
Compartment: cytoplasm
Initial concentration: 0.0394
 
 MgADP
Compartment: cytoplasm
Initial concentration: 0.1
 
 Fructose 6-phosphate
Compartment: cytoplasm
Initial concentration: 0.0153
 
 Fructose 1,6-phosphate
Compartment: cytoplasm
Initial concentration: 0.0097
 
 Glyceraldehyde 3-phosphate
Compartment: cytoplasm
Initial concentration: 0.0061
 
 Dihydroxyacetone phosphate
Compartment: cytoplasm
Initial concentration: 0.1492
 
 Phosphate
Compartment: cytoplasm
Initial concentration: 0.9992
 
 NAD
Compartment: cytoplasm
Initial concentration: 0.0653
 
 1,3-Bisphospho-D-glycerate
Compartment: cytoplasm
Initial concentration: 5.0E-4
 
 NADH
Compartment: cytoplasm
Initial concentration: 2.0E-4
 
 3-Phospho-D-glycerate
Compartment: cytoplasm
Initial concentration: 0.0658
 
 2,3-Bisphospho-D-glycerate
Compartment: cytoplasm
Initial concentration: 2.0601
 
 2-Phospho-D-glycerate
Compartment: cytoplasm
Initial concentration: 0.0084
 
 Phosphoenolpyruvate
Compartment: cytoplasm
Initial concentration: 0.0109
 
 Pyruvate
Compartment: cytoplasm
Initial concentration: 0.084
 
 Lactate
Compartment: cytoplasm
Initial concentration: 1.6803
 
 NADPH
Compartment: cytoplasm
Initial concentration: 0.004
 
 NADP
Compartment: cytoplasm
Initial concentration: 0.0
 
 AMP
Compartment: cytoplasm
Initial concentration: 0.0
 
 ADP
Compartment: cytoplasm
Initial concentration: 0.25
 
 Phospho-D-glucono-1,5-lactone
Compartment: cytoplasm
Initial concentration: 0.025
 
 Ribulose 5-phosphate
Compartment: cytoplasm
Initial concentration: 0.0047
 
 Oxidized Glutathione
Compartment: cytoplasm
Initial concentration: 4.0E-4
 
 Reduced Glutathione
Compartment: cytoplasm
Initial concentration: 3.1136
 
 Xylulose 5-phosphate
Compartment: cytoplasm
Initial concentration: 0.0127
 
 Ribose 5-phosphate
Compartment: cytoplasm
Initial concentration: 0.014
 
 Sedoheptulose 7-phosphate
Compartment: cytoplasm
Initial concentration: 0.0154
 
 Erythrose 4-phosphate
Compartment: cytoplasm
Initial concentration: 0.0063
 
 MgAMP
Compartment: cytoplasm
Initial concentration: 0.0
 
 ATP
Compartment: cytoplasm
Initial concentration: 0.25
 
 Mg
Compartment: cytoplasm
Initial concentration: 0.8
 
 MgGri23P2
Compartment: cytoplasm
Initial concentration: 0.5
 
 Protein1 bound NADP
Compartment: cytoplasm
Initial concentration: 0.0
 
 Protein1
Compartment: cytoplasm
Initial concentration: 0.0
 
 Protein1 bound NADPH
Compartment: cytoplasm
Initial concentration: 0.024
 
 Protein2 bound NADP
Compartment: cytoplasm
Initial concentration: 0.0
 
 Protein2
Compartment: cytoplasm
Initial concentration: 0.0
 
 Protein2 bound NADPH
Compartment: cytoplasm
Initial concentration: 0.024
 
 PRPP
Compartment: cytoplasm
Initial concentration: 1.0
 
 External Lactate
Compartment: cytoplasm
Initial concentration: 1.68
 
 External Pyruvate
Compartment: cytoplasm
Initial concentration: 0.084
 
 Glucose outside
Compartment: cytoplasm
Initial concentration: 5.0
 
 Phosphate external
Compartment: cytoplasm
Initial concentration: 1.0
 
Glucose transport (5)
 
   Vmaxv0
Value: 33.6   (Units: mM_per_hour)
Constant
 
   KMoutv0
Value: 1.7   (Units: mM)
Constant
 
   Keqv0
Value: 1.0   (Units: dimensionless)
Constant
 
   KMinv0
Value: 6.9   (Units: mM)
Constant
 
   alfav0
Value: 0.54   (Units: dimensionless)
Constant
 
Hexokinase (11)
 
   Inhibv1
Value: 1.0   (Units: dimensionless)
Constant
 
   KMGlcv1
Value: 0.1   (Units: mM)
Constant
 
   Vmax1v1
Value: 15.8   (Units: mM_per_hour)
Constant
 
   KMgATPv1
Value: 1.44   (Units: mM)
Constant
 
   Vmax2v1
Value: 33.2   (Units: mM_per_hour)
Constant
 
   KMgATPMgv1
Value: 1.14   (Units: mM)
Constant
 
   Keqv1
Value: 3900.0   (Units: mM)
Constant
 
   KMgv1
Value: 1.03   (Units: mM)
Constant
 
   KGlc6Pv1
Value: 0.0045   (Units: mM)
Constant
 
   K23P2Gv1
Value: 2.7   (Units: mM)
Constant
 
   KMg23P2Gv1
Value: 3.44   (Units: mM)
Constant
 
Glucosephosphate isomerase (4)
 
   Vmaxv2
Value: 935.0   (Units: mM_per_hour)
Constant
 
   Keqv2
Value: 0.3925   (Units: dimensionless)
Constant
 
   KGlc6Pv2
Value: 0.182   (Units: mM)
Constant
 
   KFru6Pv2
Value: 0.071   (Units: mM)
Constant
 
Phosphofructokinase (8)
 
   Vmaxv3
Value: 239.0   (Units: mM_per_hour)
Constant
 
   Keqv3
Value: 100000.0   (Units: dimensionless)
Constant
 
   KFru6Pv3
Value: 0.1   (Units: mM)
Constant
 
   KMgATPv3
Value: 0.068   (Units: mM)
Constant
 
   L0v3
Value: 0.001072   (Units: dimensionless)
Constant
 
   KATPv3
Value: 0.01   (Units: mM)
Constant
 
   KMgv3
Value: 0.44   (Units: mM)
Constant
 
   KAMPv3
Value: 0.033   (Units: mM)
Constant
 
Aldolase (7)
 
   Vmaxv4
Value: 98.91000366   (Units: mM_per_hour)
Constant
 
   KFru16P2v4
Value: 0.0071   (Units: mM)
Constant
 
   Keqv4
Value: 0.114   (Units: mM)
Constant
 
   KiGraPv4
Value: 0.0572   (Units: mM)
Constant
 
   KGraPv4
Value: 0.1906   (Units: mM)
Constant
 
   KDHAPv4
Value: 0.0364   (Units: mM)
Constant
 
   KiiGraPv4
Value: 0.176   (Units: mM)
Constant
 
Triosephosphate isomerase (4)
 
   Vmaxv5
Value: 5456.600098   (Units: mM_per_hour)
Constant
 
   Keqv5
Value: 0.0407   (Units: dimensionless)
Constant
 
   KDHAPv5
Value: 0.838   (Units: mM)
Constant
 
   KGraPv5
Value: 0.428   (Units: mM)
Constant
 
Glyceraldehyde 3-phosphate dehydrogenase (7)
 
   Vmaxv6
Value: 4300.0   (Units: mM_per_hour)
Constant
 
   KNADv6
Value: 0.05   (Units: mM)
Constant
 
   KGraPv6
Value: 0.005   (Units: mM)
Constant
 
   KPv6
Value: 3.9   (Units: mM)
Constant
 
   Keqv6
Value: 1.92E-4   (Units: dimensionless)
Constant
 
   KNADHv6
Value: 0.0083   (Units: mM)
Constant
 
   K13P2Gv6
Value: 0.0035   (Units: mM)
Constant
 
Phosphoglycerate kinase (6)
 
   Vmaxv7
Value: 5000.0   (Units: mM_per_hour)
Constant
 
   KMgADPv7
Value: 0.35   (Units: mM)
Constant
 
   K13P2Gv7
Value: 0.002   (Units: mM)
Constant
 
   Keqv7
Value: 1455.0   (Units: dimensionless)
Constant
 
   KMgATPv7
Value: 0.48   (Units: mM)
Constant
 
   K3PGv7
Value: 1.2   (Units: mM)
Constant
 
Bisphosphoglycerate mutase (3)
 
   kDPGMv8
Value: 76000.0   (Units: hour_inverse)
Constant
 
   Keqv8
Value: 100000.0   (Units: dimensionless)
Constant
 
   K23P2Gv8
Value: 0.04   (Units: mM)
Constant
 
Bisphosphoglycerate phosphatase (3)
 
   Vmaxv9
Value: 0.53   (Units: mM_per_hour)
Constant
 
   Keqv9
Value: 100000.0   (Units: dimensionless)
Constant
 
   K23P2Gv9
Value: 0.2   (Units: mM)
Constant
 
Phosphoglycerate mutase (4)
 
   Vmaxv10
Value: 2000.0   (Units: mM_per_hour)
Constant
 
   Keqv10
Value: 0.145   (Units: dimensionless)
Constant
 
   K3PGv10
Value: 5.0   (Units: mM)
Constant
 
   K2PGv10
Value: 1.0   (Units: mM)
Constant
 
Enolase (4)
 
   Vmaxv11
Value: 1500.0   (Units: mM_per_hour)
Constant
 
   Keqv11
Value: 1.7   (Units: dimensionless)
Constant
 
   K2PGv11
Value: 1.0   (Units: mM)
Constant
 
   KPEPv11
Value: 1.0   (Units: mM)
Constant
 
Pyruvate kinase (7)
 
   Vmaxv12
Value: 570.0   (Units: mM_per_hour)
Constant
 
   Keqv12
Value: 13790.0   (Units: dimensionless)
Constant
 
   KPEPv12
Value: 0.225   (Units: mM)
Constant
 
   KMgADPv12
Value: 0.474   (Units: mM)
Constant
 
   L0v12
Value: 19.0   (Units: dimensionless)
Constant
 
   KATPv12
Value: 3.39   (Units: mM)
Constant
 
   KFru16P2v12
Value: 0.005   (Units: mM)
Constant
 
Lactate dehydrogenase (2)
 
   Vmaxv13
Value: 2800000.0   (Units: per_mM_hour)
Constant
 
   Keqv13
Value: 9090.0   (Units: dimensionless)
Constant
 
Lactate dehydrogenase (2)
 
   kLDHv14
Value: 243.4   (Units: per_mM_hour)
Constant
 
   Keqv14
Value: 14181.8   (Units: dimensionless)
Constant
 
ATPase (1)
 
   kATPasev15
Value: 1.68   (Units: hour_inverse)
Constant
 
Adenylate kinase (5)
 
   Vmaxv16
Value: 1380.0   (Units: mM_per_hour)
Constant
 
   KATPv16
Value: 0.09   (Units: mM)
Constant
 
   KAMPv16
Value: 0.08   (Units: mM)
Constant
 
   Keqv16
Value: 0.25   (Units: dimensionless)
Constant
 
   KADPv16
Value: 0.11   (Units: mM)
Constant
 
Glucose 6-phosphate dehydrogenase (7)
 
   Vmaxv17
Value: 162.0   (Units: mM_per_hour)
Constant
 
   KG6Pv17
Value: 0.0667   (Units: mM)
Constant
 
   KNADPv17
Value: 0.00367   (Units: mM)
Constant
 
   Keqv17
Value: 2000.0   (Units: dimensionless)
Constant
 
   KATPv17
Value: 0.749   (Units: mM)
Constant
 
   KNADPHv17
Value: 0.00312   (Units: mM)
Constant
 
   KPGA23v17
Value: 2.289   (Units: mM)
Constant
 
Phosphogluconate dehydrogenase (8)
 
   Vmaxv18
Value: 1575.0   (Units: mM_per_hour)
Constant
 
   K6PG1v18
Value: 0.01   (Units: mM)
Constant
 
   KNADPv18
Value: 0.018   (Units: mM)
Constant
 
   Keqv18
Value: 141.7   (Units: dimensionless)
Constant
 
   KPGA23v18
Value: 0.12   (Units: mM)
Constant
 
   KATPv18
Value: 0.154   (Units: mM)
Constant
 
   K6PG2v18
Value: 0.058   (Units: mM)
Constant
 
   KNADPHv18
Value: 0.0045   (Units: mM)
Constant
 
Glutathione reductase (6)
 
   Vmaxv19
Value: 90.0   (Units: mM_per_hour)
Constant
 
   KGSSGv19
Value: 0.0652   (Units: mM)
Constant
 
   KNADPHv19
Value: 0.00852   (Units: mM)
Constant
 
   KGSHv19
Value: 20.0   (Units: mM)
Constant
 
   KNADPv19
Value: 0.07   (Units: mM)
Constant
 
   Keqv19
Value: 1.04   (Units: dimensionless)
Constant
 
Glutathione oxidation (1)
 
   Kv20
Value: 0.03   (Units: hour_inverse)
Constant
 
Phosphoribulose epimerase (4)
 
   Vmaxv21
Value: 4634.0   (Units: mM_per_hour)
Constant
 
   Keqv21
Value: 2.7   (Units: dimensionless)
Constant
 
   KRu5Pv21
Value: 0.19   (Units: mM)
Constant
 
   KX5Pv21
Value: 0.5   (Units: mM)
Constant
 
Ribose phosphate isomerase (4)
 
   Vmaxv22
Value: 730.0   (Units: mM_per_hour)
Constant
 
   Keqv22
Value: 3.0   (Units: dimensionless)
Constant
 
   KRu5Pv22
Value: 0.78   (Units: mM)
Constant
 
   KR5Pv22
Value: 2.2   (Units: mM)
Constant
 
Transketolase 1 (9)
 
   Vmaxv23
Value: 23.5   (Units: mM_per_hour)
Constant
 
   Keqv23
Value: 1.05   (Units: dimensionless)
Constant
 
   K1v23
Value: 0.4177   (Units: mM)
Constant
 
   K2v23
Value: 0.3055   (Units: mM)
Constant
 
   K6v23
Value: 0.00774   (Units: dimensionless)
Constant
 
   K3v23
Value: 12.432   (Units: mM)
Constant
 
   K5v23
Value: 0.41139   (Units: dimensionless)
Constant
 
   K4v23
Value: 0.00496   (Units: mM)
Constant
 
   K7v23
Value: 48.8   (Units: dimensionless)
Constant
 
Transaldolase (9)
 
   Vmaxv24
Value: 27.2   (Units: mM_per_hour)
Constant
 
   Keqv24
Value: 1.05   (Units: dimensionless)
Constant
 
   K1v24
Value: 0.00823   (Units: mM)
Constant
 
   K2v24
Value: 0.04765   (Units: mM)
Constant
 
   K6v24
Value: 0.4653   (Units: dimensionless)
Constant
 
   K3v24
Value: 0.1733   (Units: mM)
Constant
 
   K5v24
Value: 0.8683   (Units: dimensionless)
Constant
 
   K4v24
Value: 0.006095   (Units: mM)
Constant
 
   K7v24
Value: 2.524   (Units: dimensionless)
Constant
 
Phosphoribosylpyrophosphate synthetase (4)
 
   Vmaxv25
Value: 1.1   (Units: mM_per_hour)
Constant
 
   Keqv25
Value: 100000.0   (Units: dimensionless)
Constant
 
   KATPv25
Value: 0.03   (Units: mM)
Constant
 
   KR5Pv25
Value: 0.57   (Units: mM)
Constant
 
Transketolase 2 (9)
 
   Vmaxv26
Value: 23.5   (Units: mM_per_hour)
Constant
 
   Keqv26
Value: 1.2   (Units: dimensionless)
Constant
 
   K1v26
Value: 0.00184   (Units: mM)
Constant
 
   K2v26
Value: 0.3055   (Units: mM)
Constant
 
   K6v26
Value: 0.122   (Units: dimensionless)
Constant
 
   K3v26
Value: 0.0548   (Units: mM)
Constant
 
   K5v26
Value: 0.0287   (Units: dimensionless)
Constant
 
   K4v26
Value: 3.0E-4   (Units: mM)
Constant
 
   K7v26
Value: 0.215   (Units: dimensionless)
Constant
 
Phosphate exchange (2)
 
   Vmaxv27
Value: 100.0   (Units: hour_inverse)
Constant
 
   Keqv27
Value: 1.0   (Units: dimensionless)
Constant
 
Lactate exchange (2)
 
   Vmaxv28
Value: 10000.0   (Units: hour_inverse)
Constant
 
   Keqv28
Value: 1.0   (Units: dimensionless)
Constant
 
Pyruvate exchange (2)
 
   Vmaxv29
Value: 10000.0   (Units: hour_inverse)
Constant
 
   Keqv29
Value: 1.0   (Units: dimensionless)
Constant
 
MgATP dissociation (2)
 
   EqMult
Value: 1.0E7   (Units: hour_inverse)
Constant
 
   KdATP
Value: 0.072   (Units: mM)
Constant
 
MgADP dissociation (2)
 
   EqMult
Value: 1.0E7   (Units: hour_inverse)
Constant
 
   KdADP
Value: 0.76   (Units: mM)
Constant
 
MgAMP dissociation (2)
 
   EqMult
Value: 1.0E7   (Units: hour_inverse)
Constant
 
   KdAMP
Value: 16.64   (Units: mM)
Constant
 
MgGri23P2 dissociation (2)
 
   EqMult
Value: 1.0E7   (Units: hour_inverse)
Constant
 
   Kd23P2G
Value: 1.667   (Units: mM)
Constant
 
P1NADP dissociation (2)
 
   EqMult
Value: 1.0E7   (Units: hour_inverse)
Constant
 
   Kd1
Value: 2.0E-4   (Units: mM)
Constant
 
P1NADPH dissociation (2)
 
   EqMult
Value: 1.0E7   (Units: hour_inverse)
Constant
 
   Kd3
Value: 1.0E-5   (Units: mM)
Constant
 
P2NADP dissociation (2)
 
   EqMult
Value: 1.0E7   (Units: hour_inverse)
Constant
 
   Kd2
Value: 1.0E-5   (Units: mM)
Constant
 
P2NADPH dissociation (2)
 
   EqMult
Value: 1.0E7   (Units: hour_inverse)
Constant
 
   Kd4
Value: 2.0E-4   (Units: mM)
Constant
 
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