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BIOMD0000000109 - Haberichter2007_cellcycle

 

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Reference Publication
Publication ID: 17299420
Haberichter T, Mädge B, Christopher RA, Yoshioka N, Dhiman A, Miller R, Gendelman R, Aksenov SV, Khalil IG, Dowdy SF.
A systems biology dynamical model of mammalian G1 cell cycle progression.
Mol. Syst. Biol. 2007; 3: 84
Gene Network Sciences Inc., Cambridge, MA 02141, USA.  [more]
Model
Original Model: BIOMD0000000109.origin
Submitter: Enuo He
Submission ID: MODEL3734058719
Submission Date: 17 Apr 2007 22:11:32 UTC
Last Modification Date: 05 Jul 2012 15:49:20 UTC
Creation Date: 20 Mar 2007 13:29:26 UTC
Encoders:  Enuo He
   Steven Dowdy
set #1
bqbiol:hasVersion KEGG Pathway Cell cycle - Homo sapiens (human)
bqbiol:isVersionOf Gene Ontology G1 phase
bqbiol:hasTaxon Taxonomy Mammalia
Notes

This model is according to the paper A systems biology dynamical model of mammalian G1 cell cycle progression. Supplementary Figure 2A has been reproduced by the MathSBML and CellDesigner. All the data of this model are from the set 2 of Supplementary talbe2.


To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.


To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Model
Publication ID: 17299420 Submission Date: 17 Apr 2007 22:11:32 UTC Last Modification Date: 05 Jul 2012 15:49:20 UTC Creation Date: 20 Mar 2007 13:29:26 UTC
Mathematical expressions
Reactions
rxnY001 rxnY002 rxnY003 rxnY004
rxnY005 rxnY006 rxnY007 rxnY008
rxnY009 rxnY010 rxnY011 rxnY012
rxnY013 rxnY014 rxnY015 rxnY016
rxnY017 rxnY018 rxnY019 rxnY020
rxnY021 rxnY022 rxnY023 rxnY024
rxnY025 rxnY026 rxnY027 rxnY028
rxnY029 rxnY030 rxnY031 rxnY032
rxnY033 rxnY034 rxnY035 rxnY036
rxnY037 rxnY038 rxnY039 rxnY040
rxnY041 rxnY042 rxnY043 rxnY044
rxnY045 rxnY046 rxnY047 rxnY048
rxnY049 rxnY050 rxnY051 rxnY052
rxnY053 rxnY054 rxnY055 rxnY056
rxnY057 rxnY058 rxnY059 rxnY060
rxnY061 rxnY062 rxnY063 rxnY064
rxnY065 rxnY066 rxnY067 rxnY068
rxnY069 rxnY070 rxnY071 rxnY072
rxnY073 rxnY074 rxnY075 rxnY076
rxnY077 rxnY078 rxnY079 rxnY080
rxnY081 rxnY082 rxnY083 rxnY084
rxnY085 rxnY086 rxnY087 rxnY088
rxnY089 rxnY090 rxnY091 rxnY092
rxnY093 rxnY094 rxnY095 rxnY096
rxnY097 rxnY098 rxnY099 rxnY100
rxnY101 rxnY102 rxnY103 rxnY104
rxnY105 rxnY106 rxnY107 rxnY108
rxnY109 rxnY110 rxnY111 rxnY112
rxnY113 rxnY114 rxnY115 rxnY116
rxnY117 rxnY118 rxnY119 rxnY120
rxnY121 rxnY122 rxnY123 rxnY124
rxnY125 rxnY126 rxnY127 rxnY128
rxnY129 rxnY130 rxnY131 rxnY132
rxnY133 rxnY134 rxnY135 rxnY136
rxnY137 rxnY138    
Rules
Assignment Rule (variable: totalYCyclinYD) Assignment Rule (variable: totalYCyclinYE) Assignment Rule (variable: totalYCyclinYA) Assignment Rule (variable: totalYp27)
Assignment Rule (variable: hypophosphorylatedYpRb) Assignment Rule (variable: hyperphosphorylatedYpRb) Assignment Rule (variable: activeYCdk2) Assignment Rule (variable: totalYEmi1)
Assignment Rule (variable: ksYCyclinE) Assignment Rule (variable: ksYCyclinA) Assignment Rule (variable: ksYEmi1) Assignment Rule (variable: ksYE2F)
Events
modifier activation      
Physical entities
Compartments Species
cell APCC APCCYCdk1Y00YCdk1Y01YInt APCCYCdk1Y10YCdk1Y11YInt
APCCYCdk2Y000YCdk2Y002YInt APCCYCdk2Y010YCdk2Y012YInt APCCYCdk2Y100YCdk2Y102YInt
APCCYCdk2Y110YCdk2Y112YInt APCCYCyclinAYInt APCCYEmi1
Cdk1Y00 Cdk1Y01 Cdk1Y10
Cdk1Y11 Cdk1Y11YpRbY10YpRbY20YInt Cdk1Y11YpRbY11YpRbY21YInt
Cdk2Y000 Cdk2Y001 Cdk2Y002
Cdk2Y010 Cdk2Y011 Cdk2Y011YpRbY10YpRbY20YInt
Cdk2Y011YpRbY11YpRbY21YInt Cdk2Y012 Cdk2Y012YpRbY10YpRbY20YInt
Cdk2Y012YpRbY11YpRbY21YInt Cdk2Y100 Cdk2Y101
Cdk2Y102 Cdk2Y110 Cdk2Y111
Cdk2Y112 Cdk4Y00 Cdk4Y01
Cdk4Y01YpRbY00YpRbY10YInt Cdk4Y01YpRbY01YpRbY11YInt Cdk4Y10
Cdk4Y11 CyclinA CyclinD
CyclinE E2F Emi1
p27 pRbY00 pRbY01
pRbY10 pRbY11 pRbY20
pRbY21 totalYCyclinYD totalYCyclinYE
totalYCyclinYA totalYp27 hypophosphorylatedYpRb
hyperphosphorylatedYpRb totalYEmi1 activeYCdk2
Global parameters
ksYE2F ksYEmi1 ksYCyclinA ksYCyclinE
kYact ksYCyclinD ksYp27 kdYp27
kd1Yp27 ks0YCyclinE ks1YCyclinE ksMYCyclinE
ks0YCyclinA ks1YCyclinA ksMYCyclinA ks0YE2F
ks1YE2F ksMYE2F kdYE2F kd0YE2F
ks0YEmi1 ks1YEmi1 ksMYEmi1 kdYEmi1
kbYCyclinDYYCdk4 kbYp27YYCdk4 kbYp27YYCdk2 k1Yact
timeYModifier kbYCyclinEYYCdk2 kbYCyclinAYYCdk2 kbYCyclinAYYCdk1
kbYD4YYpRb kupYD4YYpRb kbYE2YYpRb kupYE2YYpRb
kbYA2YYpRb kupYA2YYpRb kbYA1YYpRb kupYA1YYpRb
ktYpRbYYDephos kbYE2FYYpRb kbYEmi1YYAPCC kbYAPCCYYCyclinA
kudYAPCCYYCyclinA kdYCyclinD kdYCyclinE kdYCyclinA
kuYCyclinDYYCdk4 kuYp27YYCdk4 kuYCyclinEYYCdk2 kuYp27YYCdk2
kuYCyclinAYYCdk2 kuYCyclinAYYCdk1 kuYD4YYpRb kuYE2YYpRb
kuYA2YYpRb kuYA1YYpRb kuYE2FYYpRb kuYEmi1YYAPCC
kuYAPCCYYCyclinA      
Reactions (138)
 
 rxnY001  → [CyclinD];  
 
 rxnY002 [CyclinD] → ;  
 
 rxnY003 [Cdk4Y01] → [Cdk4Y00];  
 
 rxnY004 [Cdk4Y11] → [Cdk4Y10];  
 
 rxnY005  → [p27];  
 
 rxnY006 [p27] → ;  
 
 rxnY007 [Cdk4Y10] → [Cdk4Y00];  
 
 rxnY008 [Cdk4Y11] → [Cdk4Y01];  
 
 rxnY009 [Cdk2Y100] → [Cdk2Y000];  
 
 rxnY010 [Cdk2Y101] → [Cdk2Y001];  
 
 rxnY011 [Cdk2Y102] → [Cdk2Y002];  
 
 rxnY012 [Cdk2Y110] → [Cdk2Y010];  
 
 rxnY013 [Cdk2Y111] → [Cdk2Y011];  
 
 rxnY014 [Cdk2Y112] → [Cdk2Y012];  
 
 rxnY015  → [CyclinE];  
 
 rxnY016 [CyclinE] → ;  
 
 rxnY017 [Cdk2Y001] → [Cdk2Y000];  
 
 rxnY018 [Cdk2Y101] → [Cdk2Y100];  
 
 rxnY019 [Cdk2Y011] → [Cdk2Y010];  
 
 rxnY020 [Cdk2Y111] → [Cdk2Y110];  
 
 rxnY021  → [CyclinA];  
 
 rxnY022 [CyclinA] → ;  
 
 rxnY023 [Cdk1Y01] → [Cdk1Y00];  
 
 rxnY024 [Cdk1Y11] → [Cdk1Y10];  
 
 rxnY025 [Cdk2Y002] → [Cdk2Y000];  
 
 rxnY026 [Cdk2Y102] → [Cdk2Y100];  
 
 rxnY027 [Cdk2Y012] → [Cdk2Y010];  
 
 rxnY028 [Cdk2Y112] → [Cdk2Y110];  
 
 rxnY029  → [E2F];  
 
 rxnY030 [E2F] → ;  
 
 rxnY031 [pRbY01] → [pRbY00];  
 
 rxnY032 [pRbY11] → [pRbY10];  
 
 rxnY033 [pRbY21] → [pRbY20];  
 
 rxnY034  → [Emi1];  
 
 rxnY035 [Emi1] → ;  
 
 rxnY036 [APCCYEmi1] → [APCC];  
 
 rxnY037 [Cdk4Y00] + [CyclinD] → [Cdk4Y01];  
 
 rxnY038 [Cdk4Y01] → [Cdk4Y00] + [CyclinD];  
 
 rxnY039 [Cdk4Y10] + [CyclinD] → [Cdk4Y11];  
 
 rxnY040 [Cdk4Y11] → [Cdk4Y10] + [CyclinD];  
 
 rxnY041 [Cdk4Y00] + [p27] → [Cdk4Y10];  
 
 rxnY042 [Cdk4Y10] → [Cdk4Y00] + [p27];  
 
 rxnY043 [Cdk4Y01] + [p27] → [Cdk4Y11];  
 
 rxnY044 [Cdk4Y11] → [Cdk4Y01] + [p27];  
 
 rxnY045 [Cdk2Y000] + [p27] → [Cdk2Y100];  
 
 rxnY046 [Cdk2Y100] → [Cdk2Y000] + [p27];  
 
 rxnY047 [Cdk2Y001] + [p27] → [Cdk2Y101];  
 
 rxnY048 [Cdk2Y101] → [Cdk2Y001] + [p27];  
 
 rxnY049 [Cdk2Y002] + [p27] → [Cdk2Y102];  
 
 rxnY050 [Cdk2Y102] → [Cdk2Y002] + [p27];  
 
 rxnY051 [Cdk2Y010] + [p27] → [Cdk2Y110];  
 
 rxnY052 [Cdk2Y110] → [Cdk2Y010] + [p27];  
 
 rxnY053 [Cdk2Y011] + [p27] → [Cdk2Y111];  
 
 rxnY054 [Cdk2Y111] → [Cdk2Y011] + [p27];  
 
 rxnY055 [Cdk2Y012] + [p27] → [Cdk2Y112];  
 
 rxnY056 [Cdk2Y112] → [Cdk2Y012] + [p27];  
 
 rxnY057 [Cdk2Y000] → [Cdk2Y010];  
 
 rxnY058 [Cdk2Y100] → [Cdk2Y110];  
 
 rxnY059 [Cdk2Y001] → [Cdk2Y011];  
 
 rxnY060 [Cdk2Y101] → [Cdk2Y111];  
 
 rxnY061 [Cdk2Y002] → [Cdk2Y012];  
 
 rxnY062 [Cdk2Y102] → [Cdk2Y112];  
 
 rxnY063 [Cdk2Y000] + [CyclinE] → [Cdk2Y001];  
 
 rxnY064 [Cdk2Y001] → [Cdk2Y000] + [CyclinE];  
 
 rxnY065 [Cdk2Y100] + [CyclinE] → [Cdk2Y101];  
 
 rxnY066 [Cdk2Y101] → [Cdk2Y100] + [CyclinE];  
 
 rxnY067 [Cdk2Y010] + [CyclinE] → [Cdk2Y011];  
 
 rxnY068 [Cdk2Y011] → [Cdk2Y010] + [CyclinE];  
 
 rxnY069 [Cdk2Y110] + [CyclinE] → [Cdk2Y111];  
 
 rxnY070 [Cdk2Y111] → [Cdk2Y110] + [CyclinE];  
 
 rxnY071 [Cdk2Y000] + [CyclinA] → [Cdk2Y002];  
 
 rxnY072 [Cdk2Y002] → [Cdk2Y000] + [CyclinA];  
 
 rxnY073 [Cdk2Y100] + [CyclinA] → [Cdk2Y102];  
 
 rxnY074 [Cdk2Y102] → [Cdk2Y100] + [CyclinA];  
 
 rxnY075 [Cdk2Y010] + [CyclinA] → [Cdk2Y012];  
 
 rxnY076 [Cdk2Y012] → [Cdk2Y010] + [CyclinA];  
 
 rxnY077 [Cdk2Y110] + [CyclinA] → [Cdk2Y112];  
 
 rxnY078 [Cdk2Y112] → [Cdk2Y110] + [CyclinA];  
 
 rxnY079 [Cdk1Y00] → [Cdk1Y10];  
 
 rxnY080 [Cdk1Y01] → [Cdk1Y11];  
 
 rxnY081 [Cdk1Y00] + [CyclinA] → [Cdk1Y01];  
 
 rxnY082 [Cdk1Y01] → [Cdk1Y00] + [CyclinA];  
 
 rxnY083 [Cdk1Y10] + [CyclinA] → [Cdk1Y11];  
 
 rxnY084 [Cdk1Y11] → [Cdk1Y10] + [CyclinA];  
 
 rxnY085 [pRbY00] + [Cdk4Y01] → [Cdk4Y01YpRbY00YpRbY10YInt];  
 
 rxnY086 [Cdk4Y01YpRbY00YpRbY10YInt] → [pRbY00] + [Cdk4Y01];  
 
 rxnY087 [Cdk4Y01YpRbY00YpRbY10YInt] → [pRbY10] + [Cdk4Y01];  
 
 rxnY088 [pRbY01] + [Cdk4Y01] → [Cdk4Y01YpRbY01YpRbY11YInt];  
 
 rxnY089 [Cdk4Y01YpRbY01YpRbY11YInt] → [pRbY01] + [Cdk4Y01];  
 
 rxnY090 [Cdk4Y01YpRbY01YpRbY11YInt] → [pRbY11] + [Cdk4Y01];  
 
 rxnY091 [pRbY10] + [Cdk2Y011] → [Cdk2Y011YpRbY10YpRbY20YInt];  
 
 rxnY092 [Cdk2Y011YpRbY10YpRbY20YInt] → [pRbY10] + [Cdk2Y011];  
 
 rxnY093 [Cdk2Y011YpRbY10YpRbY20YInt] → [pRbY20] + [Cdk2Y011];  
 
 rxnY094 [pRbY11] + [Cdk2Y011] → [Cdk2Y011YpRbY11YpRbY21YInt];  
 
 rxnY095 [Cdk2Y011YpRbY11YpRbY21YInt] → [pRbY11] + [Cdk2Y011];  
 
 rxnY096 [Cdk2Y011YpRbY11YpRbY21YInt] → [pRbY21] + [Cdk2Y011];  
 
 rxnY097 [pRbY10] + [Cdk2Y012] → [Cdk2Y012YpRbY10YpRbY20YInt];  
 
 rxnY098 [Cdk2Y012YpRbY10YpRbY20YInt] → [pRbY10] + [Cdk2Y012];  
 
 rxnY099 [Cdk2Y012YpRbY10YpRbY20YInt] → [pRbY20] + [Cdk2Y012];  
 
 rxnY100 [pRbY11] + [Cdk2Y012] → [Cdk2Y012YpRbY11YpRbY21YInt];  
 
 rxnY101 [Cdk2Y012YpRbY11YpRbY21YInt] → [pRbY11] + [Cdk2Y012];  
 
 rxnY102 [Cdk2Y012YpRbY11YpRbY21YInt] → [pRbY21] + [Cdk2Y012];  
 
 rxnY103 [pRbY10] + [Cdk1Y11] → [Cdk1Y11YpRbY10YpRbY20YInt];  
 
 rxnY104 [Cdk1Y11YpRbY10YpRbY20YInt] → [pRbY10] + [Cdk1Y11];  
 
 rxnY105 [Cdk1Y11YpRbY10YpRbY20YInt] → [pRbY20] + [Cdk1Y11];  
 
 rxnY106 [pRbY11] + [Cdk1Y11] → [Cdk1Y11YpRbY11YpRbY21YInt];   {pRbY10}
 
 rxnY107 [Cdk1Y11YpRbY11YpRbY21YInt] → [pRbY11] + [Cdk1Y11];  
 
 rxnY108 [Cdk1Y11YpRbY11YpRbY21YInt] → [pRbY21] + [Cdk1Y11];  
 
 rxnY109 [pRbY20] → [pRbY00];  
 
 rxnY110 [pRbY21] → [pRbY01];  
 
 rxnY111 [pRbY00] + [E2F] → [pRbY01];  
 
 rxnY112 [pRbY01] → [pRbY00] + [E2F];  
 
 rxnY113 [pRbY10] + [E2F] → [pRbY11];  
 
 rxnY114 [pRbY11] → [pRbY10] + [E2F];  
 
 rxnY115 [pRbY21] → [pRbY20] + [E2F];  
 
 rxnY116 [APCC] + [Emi1] → [APCCYEmi1];  
 
 rxnY117 [APCCYEmi1] → [APCC] + [Emi1];  
 
 rxnY118 [CyclinA] + [APCC] → [APCCYCyclinAYInt];  
 
 rxnY119 [APCCYCyclinAYInt] → [CyclinA] + [APCC];  
 
 rxnY120 [APCCYCyclinAYInt] → [APCC];  
 
 rxnY121 [Cdk2Y002] + [APCC] → [APCCYCdk2Y000YCdk2Y002YInt];  
 
 rxnY122 [APCCYCdk2Y000YCdk2Y002YInt] → [Cdk2Y002] + [APCC];  
 
 rxnY123 [APCCYCdk2Y000YCdk2Y002YInt] → [Cdk2Y000] + [APCC];  
 
 rxnY124 [Cdk2Y102] + [APCC] → [APCCYCdk2Y100YCdk2Y102YInt];  
 
 rxnY125 [APCCYCdk2Y100YCdk2Y102YInt] → [Cdk2Y102] + [APCC];  
 
 rxnY126 [APCCYCdk2Y100YCdk2Y102YInt] → [Cdk2Y100] + [APCC];  
 
 rxnY127 [Cdk2Y012] + [APCC] → [APCCYCdk2Y010YCdk2Y012YInt];   {Cdk2Y102}
 
 rxnY128 [APCCYCdk2Y010YCdk2Y012YInt] → [Cdk2Y012] + [APCC];  
 
 rxnY129 [APCCYCdk2Y010YCdk2Y012YInt] → [Cdk2Y010] + [APCC];  
 
 rxnY130 [Cdk2Y112] + [APCC] → [APCCYCdk2Y110YCdk2Y112YInt];  
 
 rxnY131 [APCCYCdk2Y110YCdk2Y112YInt] → [Cdk2Y112] + [APCC];  
 
 rxnY132 [APCCYCdk2Y110YCdk2Y112YInt] → [Cdk2Y110] + [APCC];  
 
 rxnY133 [Cdk1Y01] + [APCC] → [APCCYCdk1Y00YCdk1Y01YInt];  
 
 rxnY134 [APCCYCdk1Y00YCdk1Y01YInt] + [APCC] → [Cdk1Y01];  
 
 rxnY135 [APCCYCdk1Y00YCdk1Y01YInt] → [Cdk1Y00] + [APCC];  
 
 rxnY136 [Cdk1Y11] + [APCC] → [APCCYCdk1Y10YCdk1Y11YInt];  
 
 rxnY137 [APCCYCdk1Y10YCdk1Y11YInt] + [APCC] → [Cdk1Y11];  
 
 rxnY138 [APCCYCdk1Y10YCdk1Y11YInt] → [Cdk1Y10] + [APCC];  
 
Rules (12)
 
 Assignment Rule (name: totalYCyclinYD) totalYCyclinYD = CyclinD+Cdk4Y01+Cdk4Y11
 
 Assignment Rule (name: totalYCyclinYE) totalYCyclinYE = CyclinE+Cdk2Y001+Cdk2Y011+Cdk2Y101+Cdk2Y111
 
 Assignment Rule (name: totalYCyclinYA) totalYCyclinYA = CyclinA+Cdk1Y01+Cdk1Y11+Cdk2Y002+Cdk2Y012+Cdk2Y102+Cdk2Y112
 
 Assignment Rule (name: totalYp27) totalYp27 = p27+Cdk4Y10+Cdk4Y11+Cdk2Y100+Cdk2Y101+Cdk2Y102+Cdk2Y110+Cdk2Y111+Cdk2Y112
 
 Assignment Rule (name: hypophosphorylatedYpRb) hypophosphorylatedYpRb = pRbY10+pRbY11
 
 Assignment Rule (name: hyperphosphorylatedYpRb) hyperphosphorylatedYpRb = pRbY20+pRbY21
 
 Assignment Rule (name: activeYCdk2) activeYCdk2 = Cdk2Y011+Cdk2Y012
 
 Assignment Rule (name: totalYEmi1) totalYEmi1 = Emi1+APCCYEmi1
 
 Assignment Rule (name: ksYCyclinE) ksYCyclinE = ks0YCyclinE+ks1YCyclinE*E2F/(ksMYCyclinE+E2F)
 
 Assignment Rule (name: ksYCyclinA) ksYCyclinA = ks0YCyclinA+ks1YCyclinA*E2F/(ksMYCyclinA+E2F)
 
 Assignment Rule (name: ksYEmi1) ksYEmi1 = ks0YEmi1+ks1YEmi1*E2F/(ksMYEmi1+E2F)
 
 Assignment Rule (name: ksYE2F) ksYE2F = ks0YE2F+ks1YE2F*E2F/(ksMYE2F+E2F)
 
Events (1)
 
 modifier activation
kYact = k1Yact
 
 cell Spatial dimensions: 3.0  Compartment size: 1.0
 
 APCC
Compartment: cell
Initial amount: 24582.9
 
 APCCYCdk1Y00YCdk1Y01YInt
Compartment: cell
Initial amount: 104.388
 
 APCCYCdk1Y10YCdk1Y11YInt
Compartment: cell
Initial amount: 0.0
 
 APCCYCdk2Y000YCdk2Y002YInt
Compartment: cell
Initial amount: 52.8191
 
 APCCYCdk2Y010YCdk2Y012YInt
Compartment: cell
Initial amount: 0.0
 
 APCCYCdk2Y100YCdk2Y102YInt
Compartment: cell
Initial amount: 90.5091
 
 APCCYCdk2Y110YCdk2Y112YInt
Compartment: cell
Initial amount: 0.0
 
 APCCYCyclinAYInt
Compartment: cell
Initial amount: 8.79462
 
 APCCYEmi1
Compartment: cell
Initial amount: 5160.61
 
 Cdk1Y00
Compartment: cell
Initial amount: 98550.6
 
 Cdk1Y01
Compartment: cell
Initial amount: 1345.01
 
 Cdk1Y10
Compartment: cell
Initial amount: 0.0
 
 Cdk1Y11
Compartment: cell
Initial amount: 0.0
 
 Cdk1Y11YpRbY10YpRbY20YInt
Compartment: cell
Initial amount: 0.0
 
 Cdk1Y11YpRbY11YpRbY21YInt
Compartment: cell
Initial amount: 0.0
 
 Cdk2Y000
Compartment: cell
Initial amount: 33942.0
 
 Cdk2Y001
Compartment: cell
Initial amount: 2176.46
 
 Cdk2Y002
Compartment: cell
Initial amount: 680.557
 
 Cdk2Y010
Compartment: cell
Initial amount: 0.0
 
 Cdk2Y011
Compartment: cell
Initial amount: 0.0
 
 Cdk2Y011YpRbY10YpRbY20YInt
Compartment: cell
Initial amount: 0.0
 
 Cdk2Y011YpRbY11YpRbY21YInt
Compartment: cell
Initial amount: 0.0
 
 Cdk2Y012
Compartment: cell
Initial amount: 0.0
 
 Cdk2Y012YpRbY10YpRbY20YInt
Compartment: cell
Initial amount: 0.0
 
 Cdk2Y012YpRbY11YpRbY21YInt
Compartment: cell
Initial amount: 0.0
 
 Cdk2Y100
Compartment: cell
Initial amount: 58162.0
 
 Cdk2Y101
Compartment: cell
Initial amount: 3729.51
 
 Cdk2Y102
Compartment: cell
Initial amount: 1166.18
 
 Cdk2Y110
Compartment: cell
Initial amount: 0.0
 
 Cdk2Y111
Compartment: cell
Initial amount: 0.0
 
 Cdk2Y112
Compartment: cell
Initial amount: 0.0
 
 Cdk4Y00
Compartment: cell
Initial amount: 46551.9
 
 Cdk4Y01
Compartment: cell
Initial amount: 6547.64
 
 Cdk4Y01YpRbY00YpRbY10YInt
Compartment: cell
Initial amount: 0.0
 
 Cdk4Y01YpRbY01YpRbY11YInt
Compartment: cell
Initial amount: 0.0
 
 Cdk4Y10
Compartment: cell
Initial amount: 41117.2
 
 Cdk4Y11
Compartment: cell
Initial amount: 5783.23
 
 CyclinA
Compartment: cell
Initial amount: 113.316
 
 CyclinD
Compartment: cell
Initial amount: 14753.7
 
 CyclinE
Compartment: cell
Initial amount: 191.985
 
 E2F
Compartment: cell
Initial amount: 546.211
 
 Emi1
Compartment: cell
Initial amount: 248.046
 
 p27
Compartment: cell
Initial amount: 14150.9
 
 pRbY00
Compartment: cell
Initial amount: 30000.0
 
 pRbY01
Compartment: cell
Initial amount: 0.0
 
 pRbY10
Compartment: cell
Initial amount: 28583.4
 
 pRbY11
Compartment: cell
Initial amount: 1416.59
 
 pRbY20
Compartment: cell
Initial amount: 0.0
 
 pRbY21
Compartment: cell
Initial amount: 0.0
 
   totalYCyclinYD
Compartment: cell
 
   totalYCyclinYE
Compartment: cell
 
   totalYCyclinYA
Compartment: cell
 
   totalYp27
Compartment: cell
 
   hypophosphorylatedYpRb
Compartment: cell
 
   hyperphosphorylatedYpRb
Compartment: cell
 
   totalYEmi1
Compartment: cell
 
   activeYCdk2
Compartment: cell
 
Global Parameters (61)
 
   ksYE2F
Value: NaN
 
   ksYEmi1
Value: NaN
 
   ksYCyclinA
Value: NaN
 
   ksYCyclinE
Value: NaN
 
   kYact  
 
   ksYCyclinD
Value: 1354.231
Constant
 
   ksYp27
Value: 195.4716
Constant
 
   kdYp27
Value: 0.001575
Constant
 
   kd1Yp27
Value: 0.071149
Constant
 
   ks0YCyclinE
Value: 254.0742
Constant
 
   ks1YCyclinE
Value: 980.611
Constant
 
   ksMYCyclinE
Value: 9992.647
Constant
 
   ks0YCyclinA
Value: 499.9437
Constant
 
   ks1YCyclinA
Value: 7999.996
Constant
 
   ksMYCyclinA
Value: 4064.384
Constant
 
   ks0YE2F
Value: 6.927086
Constant
 
   ks1YE2F
Value: 65.44282
Constant
 
   ksMYE2F
Value: 9818.78
Constant
 
   kdYE2F
Value: 0.006465
Constant
 
   kd0YE2F
Value: 0.002229
Constant
 
   ks0YEmi1
Value: 2.004744
Constant
 
   ks1YEmi1
Value: 1788.517
Constant
 
   ksMYEmi1
Value: 9608.162
Constant
 
   kdYEmi1
Value: 0.018158
Constant
 
   kbYCyclinDYYCdk4
Value: 1.43E-6
Constant
 
   kbYp27YYCdk4
Value: 6.34E-6
Constant
 
   kbYp27YYCdk2
Value: 1.23E-5
Constant
 
   k1Yact
Value: 0.01075
Constant
 
   timeYModifier
Value: 240.0637
Constant
 
   kbYCyclinEYYCdk2
Value: 5.01E-5
Constant
 
   kbYCyclinAYYCdk2
Value: 9.52E-5
Constant
 
   kbYCyclinAYYCdk1
Value: 6.48E-5
Constant
 
   kbYD4YYpRb
Value: 3.15E-5
Constant
 
   kupYD4YYpRb
Value: 1.694662
Constant
 
   kbYE2YYpRb
Value: 5.74E-5
Constant
 
   kupYE2YYpRb
Value: 4.78271
Constant
 
   kbYA2YYpRb
Value: 6.25E-5
Constant
 
   kupYA2YYpRb
Value: 0.200091
Constant
 
   kbYA1YYpRb
Value: 6.73E-5
Constant
 
   kupYA1YYpRb
Value: 0.202132
Constant
 
   ktYpRbYYDephos
Value: 0.023194
Constant
 
   kbYE2FYYpRb
Value: 9.66E-6
Constant
 
   kbYEmi1YYAPCC
Value: 1.0E-4
Constant
 
   kbYAPCCYYCyclinA
Value: 1.61E-5
Constant
 
   kudYAPCCYYCyclinA
Value: 4.999555
Constant
 
   kdYCyclinD
Value: 0.05
Constant
 
   kdYCyclinE
Value: 0.05
Constant
 
   kdYCyclinA
Value: 0.05
Constant
 
   kuYCyclinDYYCdk4
Value: 0.1
Constant
 
   kuYp27YYCdk4
Value: 0.1
Constant
 
   kuYCyclinEYYCdk2
Value: 0.1
Constant
 
   kuYp27YYCdk2
Value: 0.1
Constant
 
   kuYCyclinAYYCdk2
Value: 0.1
Constant
 
   kuYCyclinAYYCdk1
Value: 0.1
Constant
 
   kuYD4YYpRb
Value: 0.1
Constant
 
   kuYE2YYpRb
Value: 0.1
Constant
 
   kuYA2YYpRb
Value: 0.1
Constant
 
   kuYA1YYpRb
Value: 0.1
Constant
 
   kuYE2FYYpRb
Value: 0.1
Constant
 
   kuYEmi1YYAPCC
Value: 0.1
Constant
 
   kuYAPCCYYCyclinA
Value: 0.1
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000109

Curator's comment: (updated: 17 Apr 2007 21:40:08 GMT)

Supplementary Figure2A has been reproduced by the MathSBML and CellDesigner.

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