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Chan2004_TCell_receptor_activation

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Short description

The model reproduces Fig 3a of the paper. Please note that the authors mention that they used a value of 2 for n, n being the power in the positive feedback function for kinase autocatalysis, however the model here has n=1.95 because this results in a simulation that is identical to Fig 3a. The model was successfully tested on MathSBML.

Format
SBML (L2V1)
Related Publication
  • Feedback control of T-cell receptor activation.
  • Chan C, Stark J, George AJ
  • Proceedings. Biological sciences , 5/ 2004 , Volume 271 , pages: 931-939
  • Department of Immunology, Division of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK.
  • The specificity and sensitivity of T-cell recognition is vital to the immune response. Ligand engagement with the T-cell receptor (TCR) results in the activation of a complex sequence of signalling events, both on the cell membrane and intracellularly. Feedback is an integral part of these signalling pathways, yet is often ignored in standard accounts of T-cell signalling. Here we show, using a mathematical model, that these feedback loops can explain the ability of the TCR to discriminate between ligands with high specificity and sensitivity, as well as provide a mechanism for sustained signalling. The model also explains the recent counter-intuitive observation that endogenous 'null' ligands can significantly enhance T-cell signalling. Finally, the model may provide an archetype for receptor switching based on kinase-phosphatase switches, and thus be of interest to the wider signalling community.
Contributors
Harish Dharuri

Metadata information

Curation status
Curated
Name Description Size Actions

Model files

BIOMD0000000120.xml.origin SBML L2V1 representation of Chan2004_TCell_receptor_activation 13.23 KB Preview | Download

  • Model originally submitted by : Harish Dharuri
  • Submitted: Jun 22, 2007 2:02:10 PM
  • Last Modified: Apr 8, 2016 4:36:48 PM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Apr 8, 2016 4:36:48 PM
    • Submitted by: Harish Dharuri
    • With comment: Current version of Chan2004_TCell_receptor_activation
  • Version: 1 public model Download this version
    • Submitted on: Jun 22, 2007 2:02:10 PM
    • Submitted by: Harish Dharuri
    • With comment: Original import of Chan2004_TCell_receptor_activation
Curator's comment:
(added: 22 Jun 2007, 13:20:12, updated: 22 Jun 2007, 13:20:12)
The plot corresponds to Fig 3a of the paper. Simulation results obtained from MathSBML.