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Chan2004_TCell_receptor_activation

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Short description

The model reproduces Fig 3a of the paper. Please note that the authors mention that they used a value of 2 for n, n being the power in the positive feedback function for kinase autocatalysis, however the model here has n=1.95 because this results in a simulation that is identical to Fig 3a. The model was successfully tested on MathSBML.

Format
SBML (L2V1)
Related Publication
  • Feedback control of T-cell receptor activation.
  • Chan C, Stark J, George AJ
  • Proceedings. Biological sciences , 5/ 2004 , Volume 271 , pages: 931-939
  • Department of Immunology, Division of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK.
  • The specificity and sensitivity of T-cell recognition is vital to the immune response. Ligand engagement with the T-cell receptor (TCR) results in the activation of a complex sequence of signalling events, both on the cell membrane and intracellularly. Feedback is an integral part of these signalling pathways, yet is often ignored in standard accounts of T-cell signalling. Here we show, using a mathematical model, that these feedback loops can explain the ability of the TCR to discriminate between ligands with high specificity and sensitivity, as well as provide a mechanism for sustained signalling. The model also explains the recent counter-intuitive observation that endogenous 'null' ligands can significantly enhance T-cell signalling. Finally, the model may provide an archetype for receptor switching based on kinase-phosphatase switches, and thus be of interest to the wider signalling community.
Contributors
Harish Dharuri

Metadata information

Curation status
Curated
  • Model originally submitted by : Harish Dharuri
  • Submitted: Jun 22, 2007 2:02:10 PM
  • Last Modified: Apr 8, 2016 4:36:48 PM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Apr 8, 2016 4:36:48 PM
    • Submitted by: Harish Dharuri
    • With comment: Current version of Chan2004_TCell_receptor_activation
  • Version: 1 public model Download this version
    • Submitted on: Jun 22, 2007 2:02:10 PM
    • Submitted by: Harish Dharuri
    • With comment: Original import of Chan2004_TCell_receptor_activation
Curator's comment:
(added: 22 Jun 2007, 13:20:12, updated: 22 Jun 2007, 13:20:12)
The plot corresponds to Fig 3a of the paper. Simulation results obtained from MathSBML.