BioModels Database logo

BioModels Database

spacer

BIOMD0000000135 - Izhikevich2004_SpikingNeurons_subthresholdOscillations

 

 |   |   |  Send feedback
Reference Publication
Publication ID: 15484883
Izhikevich EM.
Which model to use for cortical spiking neurons?
IEEE Trans Neural Netw 2004 Sep; 15(5): 1063-1070
The Neurosciences Institute, San Diego, CA 92121, USA. Eugene.Izhikevich@nsi.edu  [more]
Model
Original Model: http://senselab.med.yale.e...
Submitter: Enuo He
Submission ID: MODEL5570544795
Submission Date: 08 Aug 2007 15:33:24 UTC
Last Modification Date: 16 May 2012 18:09:38 UTC
Creation Date: 16 Jul 2007 17:41:14 UTC
Encoders:  Enuo He
set #1
bqbiol:occursIn Taxonomy Mammalia
bqbiol:isVersionOf Gene Ontology regulation of membrane potential
Gene Ontology action potential
Gene Ontology neuronal action potential
Notes

This a model from the article:
Which model to use for cortical spiking neurons?
Izhikevich EM. IEEE Trans Neural Netw. 2004 Sep;15(5):1063-70. 15484883 ,
Abstract:
We discuss the biological plausibility and computational efficiency of some of the most useful models of spiking and bursting neurons. We compare their applicability to large-scale simulations of cortical neural networks.

The model is according to the paper Which Model to Use for Cortical Spiking Neurons? Figure1(J) subthreshold oscillations has been reproduced by MathSBML. The ODE and the parameters values are taken from the a paper Simple Model of Spiking Neurons The original format of the models are encoded in the MATLAB format existed in the ModelDB with Accession number 39948

Figure1 are the simulation results of the same model with different choices of parameters and different stimulus function or events.a=0.05; b=0.26; c=-60; d=0; V=-62; u=b*V;

This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2010 The BioModels Team.
For more information see the terms of use .
To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.

Model
Publication ID: 15484883 Submission Date: 08 Aug 2007 15:33:24 UTC Last Modification Date: 16 May 2012 18:09:38 UTC Creation Date: 16 Jul 2007 17:41:14 UTC
Mathematical expressions
Rules
Rate Rule (variable: u) Rate Rule (variable: v)    
Events
event_0000001 event_0000002 event_0000003  
Physical entities
Compartments Species
cell      
Global parameters
a b c d
Vthresh i v u
Reactions (0)
Rules (2)
 
 Rate Rule (name: u) d [ u] / d t= a*(b*v-u)
 
 Rate Rule (name: v) d [ v] / d t= 0.04*v^2+5*v+140-u+i
 
Events (3)
 
 event_0000001
v = c
u = u+d
 
 event_0000002
i = 2
 
 event_0000003
i = 0
 
  Spatial dimensions: 3.0  Compartment size: 1.0
Global Parameters (8)
 
   a
Value: 0.05
Constant
 
   b
Value: 0.26
Constant
 
   c
Value: -60.0
Constant
 
   d
Constant
 
   Vthresh
Value: 30.0
Constant
 
   i  
 
   v
Value: -62.0
 
   u
Value: -16.12
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000135

Curator's comment: (updated: 18 Jun 2010 11:38:38 PDT)

Figure1(J)subthreshold oscillations has been simulated using Copasi v-4.5.31

spacer
spacer