public model
Short description

Model reproduces the various plots in the publication for "Control" concentrations. Model successfully tested on MathSBML.

Related Publication
  • Simulation of the regulation of EGFR endocytosis and EGFR-ERK signaling by endophilin-mediated RhoA-EGFR crosstalk.
  • Ung CY, Li H, Ma XH, Jia J, Li BW, Low BC, Chen YZ
  • FEBS letters , 6/ 2008 , Volume 582 , pages: 2283-2290
  • Bioinformatics and Drug Design Group, Department of Pharmacy, National University of Singapore, 3 Science Drive 2, Singapore 117543, Singapore.
  • Deregulations of EGFR endocytosis in EGFR-ERK signaling are known to cause cancers and developmental disorders. Mutations that impaired c-Cbl-EGFR association delay EGFR endocytosis and produce higher mitogenic signals in lung cancer. ROCK, an effector of small GTPase RhoA was shown to negatively regulate EGFR endocytosis via endophilin A1. A mathematical model was developed to study how RhoA and ROCK regulate EGFR endocytosis. Our study suggested that over-expressing RhoA as well as ROCK prolonged ERK activation partly by reducing EGFR endocytosis. Overall, our study hypothesized an alternative role of RhoA in tumorigenesis in addition to its regulation of cytoskeleton and cell motility.
Harish Dharuri

Metadata information

BioModels Database MODEL7802538336
BioModels Database BIOMD0000000205
PubMed 18505685
PubMed 14751248
PubMed 11024454
PubMed 16687399
BioModels Database BIOMD0000000049
BioModels Database BIOMD0000000019
BioModels Database BIOMD0000000048
Taxonomy Homo sapiens
Curation status
  • Model originally submitted by : Harish Dharuri
  • Submitted: Nov 27, 2008 4:27:06 PM
  • Last Modified: Apr 8, 2016 4:59:51 PM
  • Version: 2 public model Download this version
    • Submitted on: Apr 8, 2016 4:59:51 PM
    • Submitted by: Harish Dharuri
    • With comment: Current version of Ung2008_EGFR_Endocytosis
  • Version: 1 public model Download this version
    • Submitted on: Nov 27, 2008 4:27:06 PM
    • Submitted by: Harish Dharuri
    • With comment: Original import of Ung2008_EGFR_Endocytosis
Curator's comment:
(added: 27 Nov 2008, 16:26:40, updated: 27 Nov 2008, 16:26:40)
Shown here is the reproduction of the time profiles of Internalised endophilin associated EGFR (species_118) and Active ERK (species_35) for the "control" system as depicted in Fig 2 of the paper. Result obtained using MathSBML.