public model
Short description
Related Publication
  • Qualitative properties and stabilizability of a model for blood thrombin formation
  • Cunha Orfaoa S, Jank G, Mottaghy K, Walcher S, Zerz E.
  • Journal of Mathematical Analysis and Applications 2008; 346(1): 218–226 2008
  • Lehrstuhl II für Mathematik, RWTH Aachen, 52056 Aachen, Germany; Universitätsklinikum der RWTH Aachen, Pauwelsstr. 30, 52057 Aachen, Germany; Lehrstuhl A für Mathematik, RWTH Aachen, 52056 Aachen, Germany; Lehrstuhl D für Mathematik, RWTH Aachen, 52056 Aachen, Germany
  • We perform a qualitative analysis of a differential equation that was originally introduced by Stortelder, Hemker and Hemker to model the formation of thrombin, and discuss issues of controllability and stabilizability. Results include a general proof of convergence to equilibrium, and of local exponential stabilizability.
Michael Schubert

Metadata information

BioModels Database MODEL1108260000
BioModels Database BIOMD0000000366
BioModels Database BIOMD0000000358
Taxonomy Homo sapiens
Gene Ontology blood coagulation
Human Disease Ontology cardiovascular system disease
Curation status
Name Description Size Actions

Model files

BIOMD0000000366_url.xml SBML L2V4 representation of Orfao2008_ThrombinGeneration_AmidolyticActivity 19.01 KB Preview | Download

Additional files

BIOMD0000000366-biopax3.owl Auto-generated BioPAX (Level 3) 22.75 KB Preview | Download
BIOMD0000000366.vcml Auto-generated VCML file 25.53 KB Preview | Download
BIOMD0000000366.m Auto-generated Octave file 6.19 KB Preview | Download
BIOMD0000000366.sci Auto-generated Scilab file 3.55 KB Preview | Download
BIOMD0000000366.pdf Auto-generated PDF file 185.39 KB Preview | Download
BIOMD0000000366.png Auto-generated Reaction graph (PNG) 54.52 KB Preview | Download
BIOMD0000000366_urn.xml Auto-generated SBML file with URNs 18.67 KB Preview | Download
BIOMD0000000366-biopax2.owl Auto-generated BioPAX (Level 2) 14.87 KB Preview | Download
BIOMD0000000366.svg Auto-generated Reaction graph (SVG) 0.00 bytes Preview | Download
BIOMD0000000366.xpp Auto-generated XPP file 3.97 KB Preview | Download

  • Model originally submitted by : Michael Schubert
  • Submitted: Aug 26, 2011 5:10:29 PM
  • Last Modified: Oct 9, 2014 6:21:48 PM
  • Version: 2 public model Download this version
    • Submitted on: Oct 9, 2014 6:21:48 PM
    • Submitted by: Michael Schubert
    • With comment: Current version of Orfao2008_ThrombinGeneration_AmidolyticActivity
  • Version: 1 public model Download this version
    • Submitted on: Aug 26, 2011 5:10:29 PM
    • Submitted by: Michael Schubert
    • With comment: Original import of Orfao2008_ThrombinGeneration_AmidolyticActivity
Curator's comment:
(added: 26 Aug 2011, 17:34:13, updated: 26 Aug 2011, 17:34:13)
Reproduction of figure 2 of the article. Model integrated using PySCeS and plotted with Matplotlib.