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BIOMD0000000453 - Bidkhori2012 - EGFR signalling in NSCLC

 

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Reference Publication
Publication ID: 23133538
Bidkhori G, Moeini A, Masoudi-Nejad A.
Modeling of tumor progression in NSCLC and intrinsic resistance to TKI in loss of PTEN expression.
PLoS ONE 2012; 7(10): e48004
Laboratory of Systems Biology and Bioinformatics, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.  [more]
Model
Original Model: BIOMD0000000453.origin
Submitter: Gholamreza Bidkhori
Submission ID: MODEL1304020001
Submission Date: 02 Apr 2013 12:05:32 UTC
Last Modification Date: 21 Oct 2014 17:02:35 UTC
Creation Date: 13 May 2013 12:10:13 UTC
Encoders:  Vijayalakshmi Chelliah
   Gholamreza Bidkhori
set #1
bqbiol:hasProperty Human Disease Ontology non-small cell lung carcinoma
set #2
bqbiol:hasProperty Mathematical Modelling Ontology ordinary differential equation model
set #3
bqmodel:isDerivedFrom BioModels Database Yamada2003_JAK_STAT_SOCS1_knockout
BioModels Database Yamada2003_JAK_STAT_pathway
BioModels Database Ung2008_EGFR_Endocytosis
BioModels Database Huang1996 - Ultrasensitivity in MAPK cascade
BioModels Database Kholodenko1999 - EGFR signaling
BioModels Database Sasagawa2005_MAPK
BioModels Database Schoeberl2002_EGF_MAPK
PubMed 20459599
PubMed 16687399
PubMed 14751248
set #4
bqbiol:isVersionOf Gene Ontology epidermal growth factor receptor signaling pathway
set #5
bqbiol:hasTaxon Taxonomy cellular organisms
Notes
Bidkhori2012 - EGFR signalling in NSCLC

The paper describes and compares two models on EGFR signalling between normal and NSCLC cells. Moreover, it is shown that ERK (MAPK), STAT and Akt factor's activation pattern are different between normal and NSCLA models. This model corresponds to EGFR signalling in NSCLA cells.

Created by The MathWorks, Inc. SimBiology tool, Version 3.3

This model is described in the article:

Bidkhori G, Moeini A, Masoudi-Nejad A
PloS one [2012, 7(10):e48004]

Abstract:

EGFR signaling plays a very important role in NSCLC. It activates Ras/ERK, PI3K/Akt and STAT activation pathways. These are the main pathways for cell proliferation and survival. We have developed two mathematical models to relate to the different EGFR signaling in NSCLC and normal cells in the presence or absence of EGFR and PTEN mutations. The dynamics of downstream signaling pathways vary in the disease state and activation of some factors can be indicative of drug resistance. Our simulation denotes the effect of EGFR mutations and increased expression of certain factors in NSCLC EGFR signaling on each of the three pathways where levels of pERK, pSTAT and pAkt are increased. Over activation of ERK, Akt and STAT3 which are the main cell proliferation and survival factors act as promoting factors for tumor progression in NSCLC. In case of loss of PTEN, Akt activity level is considerably increased. Our simulation results show that in the presence of erlotinib, downstream factors i.e. pAkt, pSTAT3 and pERK are inhibited. However, in case of loss of PTEN expression in the presence of erlotinib, pAkt level would not decrease which demonstrates that these cells are resistant to erlotinib.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Model
Publication ID: 23133538 Submission Date: 02 Apr 2013 12:05:32 UTC Last Modification Date: 21 Oct 2014 17:02:35 UTC Creation Date: 13 May 2013 12:10:13 UTC
Mathematical expressions
Reactions
r1 r2 r3 r8
r6 r9 r7 r10
r11 r12 r13 r18
r19 r20 r23 r26
r27 r28 r29 r30
r31 r32 r35 r39
r36 r38 r37 r40
r41 r42 r43 r44
r45 r46 r47 r48
r49 r50 r51 r52
r53 r54 r55 r56
r57 r58 r59 r60
r61 r62 r63 r64
r66 r65 r67 r68
r69 r70 r71 r72
r73 r74 r75 r76
r77 r78 r79 r80
r81 r82 r83 r84
r85 r86 r87 r88
r89 r90 r91 r92
r93 r94 r95 r96
r97 r98 r99 r100
r101 r102 r103 r104
r105 r106 r107 r108
r109 r110 r111 r112
r113 r114 r115 r116
r117 r118 r119 r120
r121 r122 r123 r124
r125 r126 r127 r128
r129      
Rules
Assignment Rule (variable: pAkt_total)      
Physical entities
Compartments Species
unnamed EGF EGFR EGF-EGFR
EGF-EGFR2 pEGF-EGFR2 cbl
Shc pEGF-EGFR2-Shc SHP
pEGF-EGFR2-SHP2 pEGF-EGFR2-pShc pShc
pShc-SHP2 Grb2 pEGF-EGFR2-pShc-Grb2
pEGF-EGFR2-pShc-Grb2-SHP2 SOS pEGF-EGFR2-pShc-Grb2-SOS
pEGF-EGFR2-pShc-Grb2-SOS-cbl Grb2-SOS pEGF-EGFR2-Grb2
pEGF-EGFR2-Grb2-SHP2 pEGF-EGFR2-Grb2-SOS pEGF-EGFR2-Grb2-SOS-cbl
Ras-GDP pEGF-EGFR2-pShc-Grb2-SOS-Ras-GDP Ras-GTP
pEGF-EGFR2-Grb2-SOS-Ras-GDP Ras-GAP Ras-GTP-Ras-GAP
pEGF-EGFR2-Ras-GAP pEGF-EGFR2-Ras-GAP-Ras-GTP pEGF-EGFR2-Ras-GAP-SHP2
Raf1 Raf1-Ras-GTP Raf1active
MEK Raf1active-MEK pMEK
Raf1active-pMEK ppMEK ERK
ppMEK-ERK pERK ppMEK-pERK
ppERK Pase Raf1active-Pase
Pase2 ppMEK-Pase2 pMEK-Pase2
Pase3 pERK-Pase3 ppERK-Pase3
ppERK-pEGF-EGFR2-pShc-Grb2-SOS pSOS ppERK-pEGF-EGFR2-Grb2-SOS
ProEGFR pEGF-EGFR2-pShc-Grb2-SOS-cbl-EPn EPn
pEGF-EGFR2-Grb2-SOS-cbl-EPn pEGF-EGFR2-cbl pEGF-EGFR2-cbl-EPn
PI3K pEGF-EGFR2-PI3K pEGF-EGFR2-pPI3K
pPI3K TP4 TP4-pPI3K
TP4-PI3K PIP2 pPI3K-PIP2
PIP3 Akt Aktm
PDK1 Aktm-PDK1 pAktm-PDK1
pAktm pAkt pAkt-Takt
Akt-Takt Takt pAktm-Takt
Aktm-Takt pAktm-PDK1-Takt Aktm-PDK1-Takt
pAkt_total pRaf1active STAT3c
pEGF-EGFR2-STAT3c pSTAT3c pEGF-EGFR2-pSTAT3c
PP1 pSTAT3c-PP1 pSTAT3c-pSTAT3c-PP1
pSTAT3c-pSTAT3c STAT3c-pSTAT3c pSTAT3n-pSTAT3n
pSTAT3n PP2 pSTAT3n-pSTAT3n-PP2
STAT3n-pSTAT3n STAT3n pSTAT3n-PP2
pEGF-EGFR2-STAT3c-cbl pEGF-EGFR2-STAT3c-cbl-EPn pEGF-EGFR2-PI3K-cbl
pEGF-EGFR2-PI3K-cbl-EPn    
Reactions (117)
 
 r1 [EGF] + [EGFR] ↔ [EGF-EGFR];   {EGF} , {EGFR} , {EGF-EGFR}
 
 r2 [EGF-EGFR] + [EGF-EGFR] ↔ [EGF-EGFR2];   {EGF-EGFR} , {EGF-EGFR2}
 
 r3 [EGF-EGFR2] → [pEGF-EGFR2];   {EGF-EGFR2}
 
 r8 [pEGF-EGFR2] + [Shc] ↔ [pEGF-EGFR2-Shc];   {pEGF-EGFR2} , {Shc} , {pEGF-EGFR2-Shc}
 
 r6 [pEGF-EGFR2] + [SHP] ↔ [pEGF-EGFR2-SHP2];   {pEGF-EGFR2} , {SHP} , {pEGF-EGFR2-SHP2}
 
 r9 [pEGF-EGFR2-Shc] → [pEGF-EGFR2-pShc];   {pEGF-EGFR2-Shc}
 
 r7 [pEGF-EGFR2-SHP2] → [EGF-EGFR2] + [SHP];   {pEGF-EGFR2-SHP2}
 
 r10 [pEGF-EGFR2-pShc] ↔ [pEGF-EGFR2] + [pShc];   {pEGF-EGFR2-pShc} , {pEGF-EGFR2} , {pShc}
 
 r11 [pShc] + [SHP] ↔ [pShc-SHP2];   {pShc} , {SHP} , {pShc-SHP2}
 
 r12 [pShc-SHP2] → [Shc] + [SHP];   {pShc-SHP2}
 
 r13 [pShc] → [Shc];   {pShc}
 
 r18 [pEGF-EGFR2-pShc] + [Grb2] ↔ [pEGF-EGFR2-pShc-Grb2];   {pEGF-EGFR2-pShc} , {Grb2} , {pEGF-EGFR2-pShc-Grb2}
 
 r19 [pEGF-EGFR2-pShc-Grb2] + [SHP] ↔ [pEGF-EGFR2-pShc-Grb2-SHP2];   {pEGF-EGFR2-pShc-Grb2} , {SHP} , {pEGF-EGFR2-pShc-Grb2-SHP2}
 
 r20 [pEGF-EGFR2-pShc-Grb2-SHP2] → [EGF-EGFR2] + [pShc] + [Grb2] + [SHP];   {pEGF-EGFR2-pShc-Grb2-SHP2}
 
 r23 [pEGF-EGFR2-pShc-Grb2] + [SOS] ↔ [pEGF-EGFR2-pShc-Grb2-SOS];   {pEGF-EGFR2-pShc-Grb2} , {SOS} , {pEGF-EGFR2-pShc-Grb2-SOS}
 
 r26 [Grb2] + [SOS] ↔ [Grb2-SOS];   {Grb2} , {SOS} , {Grb2-SOS}
 
 r27 [pEGF-EGFR2-pShc] + [Grb2-SOS] ↔ [pEGF-EGFR2-pShc-Grb2-SOS];   {pEGF-EGFR2-pShc} , {Grb2-SOS} , {pEGF-EGFR2-pShc-Grb2-SOS}
 
 r28 [pEGF-EGFR2] + [Grb2] ↔ [pEGF-EGFR2-Grb2];   {pEGF-EGFR2} , {Grb2} , {pEGF-EGFR2-Grb2}
 
 r29 [pEGF-EGFR2-Grb2] + [SHP] ↔ [pEGF-EGFR2-Grb2-SHP2];   {pEGF-EGFR2-Grb2} , {SHP} , {pEGF-EGFR2-Grb2-SHP2}
 
 r30 [pEGF-EGFR2-Grb2-SHP2] → [EGF-EGFR2] + [Grb2] + [SHP];   {pEGF-EGFR2-Grb2-SHP2}
 
 r31 [pEGF-EGFR2-Grb2] + [SOS] ↔ [pEGF-EGFR2-Grb2-SOS];   {pEGF-EGFR2-Grb2} , {SOS} , {pEGF-EGFR2-Grb2-SOS}
 
 r32 [pEGF-EGFR2] + [Grb2-SOS] ↔ [pEGF-EGFR2-Grb2-SOS];   {pEGF-EGFR2} , {Grb2-SOS} , {pEGF-EGFR2-Grb2-SOS}
 
 r35 [pEGF-EGFR2-pShc-Grb2-SOS] + [Ras-GDP] ↔ [pEGF-EGFR2-pShc-Grb2-SOS-Ras-GDP];   {pEGF-EGFR2-pShc-Grb2-SOS} , {Ras-GDP} , {pEGF-EGFR2-pShc-Grb2-SOS-Ras-GDP}
 
 r39 [Ras-GTP] → [Ras-GDP];   {Ras-GTP}
 
 r36 [pEGF-EGFR2-pShc-Grb2-SOS-Ras-GDP] → [pEGF-EGFR2-pShc-Grb2-SOS] + [Ras-GTP];   {pEGF-EGFR2-pShc-Grb2-SOS-Ras-GDP}
 
 r38 [pEGF-EGFR2-Grb2-SOS-Ras-GDP] → [pEGF-EGFR2-Grb2-SOS] + [Ras-GTP];   {pEGF-EGFR2-Grb2-SOS-Ras-GDP}
 
 r37 [pEGF-EGFR2-Grb2-SOS] + [Ras-GDP] ↔ [pEGF-EGFR2-Grb2-SOS-Ras-GDP];   {pEGF-EGFR2-Grb2-SOS} , {Ras-GDP} , {pEGF-EGFR2-Grb2-SOS-Ras-GDP}
 
 r40 [Ras-GTP] + [Ras-GAP] ↔ [Ras-GTP-Ras-GAP];   {Ras-GTP} , {Ras-GAP} , {Ras-GTP-Ras-GAP}
 
 r41 [Ras-GTP-Ras-GAP] → [Ras-GDP] + [Ras-GAP];   {Ras-GTP-Ras-GAP}
 
 r42 [pEGF-EGFR2] + [Ras-GAP] ↔ [pEGF-EGFR2-Ras-GAP];   {pEGF-EGFR2} , {Ras-GAP} , {pEGF-EGFR2-Ras-GAP}
 
 r43 [pEGF-EGFR2-Ras-GAP] + [Ras-GTP] ↔ [pEGF-EGFR2-Ras-GAP-Ras-GTP];   {pEGF-EGFR2-Ras-GAP} , {Ras-GTP} , {pEGF-EGFR2-Ras-GAP-Ras-GTP}
 
 r44 [pEGF-EGFR2-Ras-GAP-Ras-GTP] → [pEGF-EGFR2-Ras-GAP] + [Ras-GDP];   {pEGF-EGFR2-Ras-GAP-Ras-GTP}
 
 r45 [pEGF-EGFR2-Ras-GAP] + [SHP] ↔ [pEGF-EGFR2-Ras-GAP-SHP2];   {pEGF-EGFR2-Ras-GAP} , {SHP} , {pEGF-EGFR2-Ras-GAP-SHP2}
 
 r46 [pEGF-EGFR2-Ras-GAP-SHP2] → [EGF-EGFR2] + [Ras-GAP] + [SHP];   {pEGF-EGFR2-Ras-GAP-SHP2}
 
 r47 [Raf1] + [Ras-GTP] ↔ [Raf1-Ras-GTP];   {Raf1} , {Ras-GTP} , {Raf1-Ras-GTP}
 
 r48 [Raf1-Ras-GTP] → [Raf1active] + [Ras-GTP];   {Raf1-Ras-GTP}
 
 r49 [Raf1active] + [MEK] ↔ [Raf1active-MEK];   {Raf1active} , {MEK} , {Raf1active-MEK}
 
 r50 [Raf1active-MEK] → [Raf1active] + [pMEK];   {Raf1active-MEK}
 
 r51 [Raf1active] + [pMEK] ↔ [Raf1active-pMEK];   {Raf1active} , {pMEK} , {Raf1active-pMEK}
 
 r52 [Raf1active-pMEK] → [Raf1active] + [ppMEK];   {Raf1active-pMEK}
 
 r53 [ppMEK] + [ERK] ↔ [ppMEK-ERK];   {ppMEK} , {ERK} , {ppMEK-ERK}
 
 r54 [ppMEK-ERK] → [ppMEK] + [pERK];   {ppMEK-ERK}
 
 r55 [ppMEK] + [pERK] ↔ [ppMEK-pERK];   {ppMEK} , {pERK} , {ppMEK-pERK}
 
 r56 [ppMEK-pERK] → [ppMEK] + [ppERK];   {ppMEK-pERK}
 
 r57 [Raf1active] + [Pase] ↔ [Raf1active-Pase];   {Raf1active} , {Pase} , {Raf1active-Pase}
 
 r58 [Raf1active-Pase] → [Raf1] + [Pase];   {Raf1active-Pase}
 
 r59 [ppMEK] + [Pase2] ↔ [ppMEK-Pase2];   {ppMEK} , {Pase2} , {ppMEK-Pase2}
 
 r60 [ppMEK-Pase2] → [pMEK] + [Pase2];   {ppMEK-Pase2}
 
 r61 [pMEK] + [Pase2] ↔ [pMEK-Pase2];   {pMEK} , {Pase2} , {pMEK-Pase2}
 
 r62 [pMEK-Pase2] → [MEK] + [Pase2];   {pMEK-Pase2}
 
 r63 [ppERK] + [Pase3] ↔ [ppERK-Pase3];   {ppERK} , {Pase3} , {ppERK-Pase3}
 
 r64 [ppERK-Pase3] → [pERK] + [Pase3];   {ppERK-Pase3}
 
 r66 [pERK-Pase3] → [ERK] + [Pase3];   {pERK-Pase3}
 
 r65 [pERK] + [Pase3] ↔ [pERK-Pase3];   {pERK} , {Pase3} , {pERK-Pase3}
 
 r67 [ppERK] + [pEGF-EGFR2-pShc-Grb2-SOS] ↔ [ppERK-pEGF-EGFR2-pShc-Grb2-SOS];   {ppERK} , {pEGF-EGFR2-pShc-Grb2-SOS} , {ppERK-pEGF-EGFR2-pShc-Grb2-SOS}
 
 r68 [ppERK-pEGF-EGFR2-pShc-Grb2-SOS] → [ppERK] + [pEGF-EGFR2] + [pShc] + [Grb2] + [pSOS];   {ppERK-pEGF-EGFR2-pShc-Grb2-SOS}
 
 r69 [ppERK] + [pEGF-EGFR2-Grb2-SOS] ↔ [ppERK-pEGF-EGFR2-Grb2-SOS];   {ppERK} , {pEGF-EGFR2-Grb2-SOS} , {ppERK-pEGF-EGFR2-Grb2-SOS}
 
 r70 [ppERK-pEGF-EGFR2-Grb2-SOS] → [ppERK] + [pEGF-EGFR2] + [Grb2] + [pSOS];   {ppERK-pEGF-EGFR2-Grb2-SOS}
 
 r71 [pSOS] → [SOS];   {pSOS}
 
 r72 [ProEGFR] → [EGFR];   {ProEGFR}
 
 r73 [pEGF-EGFR2-pShc-Grb2-SOS] + [cbl] ↔ [pEGF-EGFR2-pShc-Grb2-SOS-cbl];   {pEGF-EGFR2-pShc-Grb2-SOS} , {cbl} , {pEGF-EGFR2-pShc-Grb2-SOS-cbl}
 
 r74 [pEGF-EGFR2-pShc-Grb2-SOS-cbl] + [EPn] ↔ [pEGF-EGFR2-pShc-Grb2-SOS-cbl-EPn];   {pEGF-EGFR2-pShc-Grb2-SOS-cbl} , {EPn} , {pEGF-EGFR2-pShc-Grb2-SOS-cbl-EPn}
 
 r75 [pEGF-EGFR2-pShc-Grb2-SOS-cbl-EPn] → [cbl] + [Grb2-SOS] + [EPn] + [pShc];   {pEGF-EGFR2-pShc-Grb2-SOS-cbl-EPn}
 
 r76 [pEGF-EGFR2-Grb2-SOS] + [cbl] ↔ [pEGF-EGFR2-Grb2-SOS-cbl];   {pEGF-EGFR2-Grb2-SOS} , {cbl} , {pEGF-EGFR2-Grb2-SOS-cbl}
 
 r77 [pEGF-EGFR2-Grb2-SOS-cbl] + [EPn] ↔ [pEGF-EGFR2-Grb2-SOS-cbl-EPn];   {pEGF-EGFR2-Grb2-SOS-cbl} , {EPn} , {pEGF-EGFR2-Grb2-SOS-cbl-EPn}
 
 r78 [pEGF-EGFR2-Grb2-SOS-cbl-EPn] → [cbl] + [Grb2-SOS] + [EPn];   {pEGF-EGFR2-Grb2-SOS-cbl-EPn}
 
 r79 [pEGF-EGFR2] + [cbl] ↔ [pEGF-EGFR2-cbl];   {pEGF-EGFR2} , {cbl} , {pEGF-EGFR2-cbl}
 
 r80 [pEGF-EGFR2-cbl] + [EPn] ↔ [pEGF-EGFR2-cbl-EPn];   {pEGF-EGFR2-cbl} , {EPn} , {pEGF-EGFR2-cbl-EPn}
 
 r81 [pEGF-EGFR2-cbl-EPn] → [cbl] + [EPn];   {pEGF-EGFR2-cbl-EPn}
 
 r82 [pEGF-EGFR2] + [PI3K] ↔ [pEGF-EGFR2-PI3K];   {pEGF-EGFR2} , {PI3K} , {pEGF-EGFR2-PI3K}
 
 r83 [pEGF-EGFR2-PI3K] ↔ [pEGF-EGFR2-pPI3K];   {pEGF-EGFR2-PI3K} , {pEGF-EGFR2-pPI3K}
 
 r84 [pEGF-EGFR2-PI3K] ↔ [pEGF-EGFR2] + [pPI3K];   {pEGF-EGFR2-PI3K} , {pEGF-EGFR2} , {pPI3K}
 
 r85 [TP4] + [pPI3K] ↔ [TP4-pPI3K];   {TP4} , {pPI3K} , {TP4-pPI3K}
 
 r86 [TP4-pPI3K] → [TP4-PI3K];   {TP4-pPI3K}
 
 r87 [TP4-PI3K] ↔ [TP4] + [PI3K];   {TP4-PI3K} , {TP4} , {PI3K}
 
 r88 [pPI3K] + [PIP2] ↔ [pPI3K-PIP2];   {pPI3K} , {PIP2} , {pPI3K-PIP2}
 
 r89 [pPI3K-PIP2] → [pPI3K] + [PIP3];   {pPI3K-PIP2}
 
 r90 [Akt] + [PIP3] ↔ [Aktm];   {Akt} , {PIP3} , {Aktm}
 
 r91 [Aktm] + [PDK1] ↔ [Aktm-PDK1];   {Aktm} , {PDK1} , {Aktm-PDK1}
 
 r92 [Aktm-PDK1] → [pAktm-PDK1];   {Aktm-PDK1}
 
 r93 [pAktm-PDK1] ↔ [pAktm] + [PDK1];   {pAktm-PDK1} , {pAktm} , {PDK1}
 
 r94 [pAktm] ↔ [pAkt] + [PIP3];   {pAktm} , {pAkt} , {PIP3}
 
 r95 [pAkt-Takt] → [Akt-Takt];   {pAkt-Takt}
 
 r96 [Akt-Takt] ↔ [Akt] + [Takt];   {Akt-Takt} , {Akt} , {Takt}
 
 r97 [pAkt] + [Takt] ↔ [pAkt-Takt];   {pAkt} , {Takt} , {pAkt-Takt}
 
 r98 [pAktm] + [Takt] ↔ [pAktm-Takt];   {pAktm} , {Takt} , {pAktm-Takt}
 
 r99 [pAktm-Takt] → [Aktm-Takt];   {pAktm-Takt}
 
 r100 [Aktm-Takt] ↔ [Aktm] + [Takt];   {Aktm-Takt} , {Aktm} , {Takt}
 
 r101 [pAktm-PDK1] + [Takt] ↔ [pAktm-PDK1-Takt];   {pAktm-PDK1} , {Takt} , {pAktm-PDK1-Takt}
 
 r102 [pAktm-PDK1-Takt] → [Aktm-PDK1-Takt];   {pAktm-PDK1-Takt}
 
 r103 [Aktm-PDK1-Takt] ↔ [Aktm-PDK1] + [Takt];   {Aktm-PDK1-Takt} , {Aktm-PDK1} , {Takt}
 
 r104 [Raf1active] → [pRaf1active];   {pAkt_total} , {pAkt_total} , {Raf1active}
 
 r105 [pRaf1active] → [Raf1active];   {pRaf1active}
 
 r106 [pEGF-EGFR2] + [STAT3c] ↔ [pEGF-EGFR2-STAT3c];   {pEGF-EGFR2} , {STAT3c} , {pEGF-EGFR2-STAT3c}
 
 r107 [pEGF-EGFR2-STAT3c] → [pEGF-EGFR2] + [pSTAT3c];   {pEGF-EGFR2-STAT3c}
 
 r108 [pEGF-EGFR2] + [pSTAT3c] ↔ [pEGF-EGFR2-pSTAT3c];   {pEGF-EGFR2} , {pSTAT3c} , {pEGF-EGFR2-pSTAT3c}
 
 r109 [pSTAT3c] + [PP1] ↔ [pSTAT3c-PP1];   {pSTAT3c} , {PP1} , {pSTAT3c-PP1}
 
 r110 [pSTAT3c-PP1] → [STAT3c] + [PP1];   {pSTAT3c-PP1}
 
 r111 [pSTAT3c] + [pSTAT3c] ↔ [pSTAT3c-pSTAT3c];   {pSTAT3c} , {pSTAT3c-pSTAT3c}
 
 r112 [pSTAT3c-pSTAT3c] + [PP1] ↔ [pSTAT3c-pSTAT3c-PP1];   {pSTAT3c-pSTAT3c} , {PP1} , {pSTAT3c-pSTAT3c-PP1}
 
 r113 [pSTAT3c-pSTAT3c-PP1] → [STAT3c-pSTAT3c] + [PP1];   {pSTAT3c-pSTAT3c-PP1}
 
 r114 [STAT3c] + [pSTAT3c] ↔ [STAT3c-pSTAT3c];   {STAT3c} , {pSTAT3c} , {STAT3c-pSTAT3c}
 
 r115 [pSTAT3c-pSTAT3c] → [pSTAT3n-pSTAT3n];   {pSTAT3c-pSTAT3c}
 
 r116 [pSTAT3n] + [pSTAT3n] ↔ [pSTAT3n-pSTAT3n];   {pSTAT3n} , {pSTAT3n-pSTAT3n}
 
 r117 [pSTAT3n-pSTAT3n] + [PP2] ↔ [pSTAT3n-pSTAT3n-PP2];   {pSTAT3n-pSTAT3n} , {PP2} , {pSTAT3n-pSTAT3n-PP2}
 
 r118 [pSTAT3n-pSTAT3n-PP2] → [STAT3n-pSTAT3n] + [PP2];   {pSTAT3n-pSTAT3n-PP2}
 
 r119 [STAT3n] + [pSTAT3n] ↔ [STAT3n-pSTAT3n];   {STAT3n} , {pSTAT3n} , {STAT3n-pSTAT3n}
 
 r120 [pSTAT3n] + [PP2] ↔ [pSTAT3n-PP2];   {pSTAT3n} , {PP2} , {pSTAT3n-PP2}
 
 r121 [pSTAT3n-PP2] → [STAT3n] + [PP2];   {pSTAT3n-PP2}
 
 r122 [STAT3n] → [STAT3c];   {STAT3n}
 
 r123 [PIP3] → [PIP2];   {PIP3}
 
 r124 [pEGF-EGFR2-STAT3c] + [cbl] ↔ [pEGF-EGFR2-STAT3c-cbl];   {pEGF-EGFR2-STAT3c} , {cbl} , {pEGF-EGFR2-STAT3c-cbl}
 
 r125 [pEGF-EGFR2-STAT3c-cbl] + [EPn] ↔ [pEGF-EGFR2-STAT3c-cbl-EPn];   {pEGF-EGFR2-STAT3c-cbl} , {EPn} , {pEGF-EGFR2-STAT3c-cbl-EPn}
 
 r126 [pEGF-EGFR2-STAT3c-cbl-EPn] → [STAT3c] + [cbl] + [EPn];   {pEGF-EGFR2-STAT3c-cbl-EPn}
 
 r127 [pEGF-EGFR2-PI3K] + [cbl] ↔ [pEGF-EGFR2-PI3K-cbl];   {pEGF-EGFR2-PI3K} , {cbl} , {pEGF-EGFR2-PI3K-cbl}
 
 r128 [pEGF-EGFR2-PI3K-cbl] + [EPn] ↔ [pEGF-EGFR2-PI3K-cbl-EPn];   {pEGF-EGFR2-PI3K-cbl} , {EPn} , {pEGF-EGFR2-PI3K-cbl-EPn}
 
 r129 [pEGF-EGFR2-PI3K-cbl-EPn] → [PI3K] + [EPn];   {pEGF-EGFR2-PI3K-cbl-EPn}
 
Rules (1)
 
 Assignment Rule (name: mwa6994523_5d45_4000_af0c_3e94073bf183) pAkt_total = mw16796ffe_4764_4a9f_942e_149f42c1cd28+mw3d81860d_d786_4fcc_b8bb_64f1a2d7739d
 
 unnamed Spatial dimensions: 3.0  Compartment size: 1.0
 
 EGF
Compartment: unnamed
Initial amount: 0.0081967
 
 EGFR
Compartment: unnamed
Initial amount: 1.0
 
 EGF-EGFR
Compartment: unnamed
Initial amount: 0.0
 
 EGF-EGFR2
Compartment: unnamed
Initial amount: 0.0
 
 pEGF-EGFR2
Compartment: unnamed
Initial amount: 0.0
 
 cbl
Compartment: unnamed
Initial amount: 0.8
 
 Shc
Compartment: unnamed
Initial amount: 1.0
 
 pEGF-EGFR2-Shc
Compartment: unnamed
Initial amount: 0.0
 
 SHP
Compartment: unnamed
Initial amount: 0.2
 
 pEGF-EGFR2-SHP2
Compartment: unnamed
Initial amount: 0.0
 
 pEGF-EGFR2-pShc
Compartment: unnamed
Initial amount: 0.0
 
 pShc
Compartment: unnamed
Initial amount: 0.0
 
 pShc-SHP2
Compartment: unnamed
Initial amount: 0.0
 
 Grb2
Compartment: unnamed
Initial amount: 1.0
 
 pEGF-EGFR2-pShc-Grb2
Compartment: unnamed
Initial amount: 0.0
 
 pEGF-EGFR2-pShc-Grb2-SHP2
Compartment: unnamed
Initial amount: 0.0
 
 SOS
Compartment: unnamed
Initial amount: 0.3
 
 pEGF-EGFR2-pShc-Grb2-SOS
Compartment: unnamed
Initial amount: 0.0
 
 pEGF-EGFR2-pShc-Grb2-SOS-cbl
Compartment: unnamed
Initial amount: 0.0
 
 Grb2-SOS
Compartment: unnamed
Initial amount: 0.0
 
 pEGF-EGFR2-Grb2
Compartment: unnamed
Initial amount: 0.0
 
 pEGF-EGFR2-Grb2-SHP2
Compartment: unnamed
Initial amount: 0.0
 
 pEGF-EGFR2-Grb2-SOS
Compartment: unnamed
Initial amount: 0.0
 
 pEGF-EGFR2-Grb2-SOS-cbl
Compartment: unnamed
Initial amount: 0.0
 
 Ras-GDP
Compartment: unnamed
Initial amount: 0.3
 
 pEGF-EGFR2-pShc-Grb2-SOS-Ras-GDP
Compartment: unnamed
Initial amount: 0.0
 
 Ras-GTP
Compartment: unnamed
Initial amount: 0.0
 
 pEGF-EGFR2-Grb2-SOS-Ras-GDP
Compartment: unnamed
Initial amount: 0.0
 
 Ras-GAP
Compartment: unnamed
Initial amount: 0.1
 
 Ras-GTP-Ras-GAP
Compartment: unnamed
Initial amount: 0.0
 
 pEGF-EGFR2-Ras-GAP
Compartment: unnamed
Initial amount: 0.0
 
 pEGF-EGFR2-Ras-GAP-Ras-GTP
Compartment: unnamed
Initial amount: 0.0
 
 pEGF-EGFR2-Ras-GAP-SHP2
Compartment: unnamed
Initial amount: 0.0
 
 Raf1
Compartment: unnamed
Initial amount: 0.5
 
 Raf1-Ras-GTP
Compartment: unnamed
Initial amount: 0.0
 
 Raf1active
Compartment: unnamed
Initial amount: 0.0
 
 MEK
Compartment: unnamed
Initial amount: 0.68
 
 Raf1active-MEK
Compartment: unnamed
Initial amount: 0.0
 
 pMEK
Compartment: unnamed
Initial amount: 0.0
 
 Raf1active-pMEK
Compartment: unnamed
Initial amount: 0.0
 
 ppMEK
Compartment: unnamed
Initial amount: 0.0
 
 ERK
Compartment: unnamed
Initial amount: 0.8
 
 ppMEK-ERK
Compartment: unnamed
Initial amount: 0.0
 
 pERK
Compartment: unnamed
Initial amount: 0.0
 
 ppMEK-pERK
Compartment: unnamed
Initial amount: 0.0
 
 ppERK
Compartment: unnamed
Initial amount: 0.0
 
 Pase
Compartment: unnamed
Initial amount: 0.5
 
 Raf1active-Pase
Compartment: unnamed
Initial amount: 0.0
 
 Pase2
Compartment: unnamed
Initial amount: 0.02
 
 ppMEK-Pase2
Compartment: unnamed
Initial amount: 0.0
 
 pMEK-Pase2
Compartment: unnamed
Initial amount: 0.0
 
 Pase3
Compartment: unnamed
Initial amount: 0.002
 
 pERK-Pase3
Compartment: unnamed
Initial amount: 0.0
 
 ppERK-Pase3
Compartment: unnamed
Initial amount: 0.0
 
 ppERK-pEGF-EGFR2-pShc-Grb2-SOS
Compartment: unnamed
Initial amount: 0.0
 
 pSOS
Compartment: unnamed
Initial amount: 0.0
 
 ppERK-pEGF-EGFR2-Grb2-SOS
Compartment: unnamed
Initial amount: 0.0
 
 ProEGFR
Compartment: unnamed
Initial amount: 1.0
 
 pEGF-EGFR2-pShc-Grb2-SOS-cbl-EPn
Compartment: unnamed
Initial amount: 0.0
 
 EPn
Compartment: unnamed
Initial amount: 0.5
 
 pEGF-EGFR2-Grb2-SOS-cbl-EPn
Compartment: unnamed
Initial amount: 0.0
 
 pEGF-EGFR2-cbl
Compartment: unnamed
Initial amount: 0.0
 
 pEGF-EGFR2-cbl-EPn
Compartment: unnamed
Initial amount: 0.0
 
 PI3K
Compartment: unnamed
Initial amount: 0.4
 
 pEGF-EGFR2-PI3K
Compartment: unnamed
Initial amount: 0.0
 
 pEGF-EGFR2-pPI3K
Compartment: unnamed
Initial amount: 0.0
 
 pPI3K
Compartment: unnamed
Initial amount: 0.0
 
 TP4
Compartment: unnamed
Initial amount: 0.2
 
 TP4-pPI3K
Compartment: unnamed
Initial amount: 0.0
 
 TP4-PI3K
Compartment: unnamed
Initial amount: 0.0
 
 PIP2
Compartment: unnamed
Initial amount: 0.5
 
 pPI3K-PIP2
Compartment: unnamed
Initial amount: 0.0
 
 PIP3
Compartment: unnamed
Initial amount: 0.0
 
 Akt
Compartment: unnamed
Initial amount: 0.2
 
 Aktm
Compartment: unnamed
Initial amount: 0.0
 
 PDK1
Compartment: unnamed
Initial amount: 0.1
 
 Aktm-PDK1
Compartment: unnamed
Initial amount: 0.0
 
 pAktm-PDK1
Compartment: unnamed
Initial amount: 0.0
 
 pAktm
Compartment: unnamed
Initial amount: 0.0
 
 pAkt
Compartment: unnamed
Initial amount: 0.0
 
 pAkt-Takt
Compartment: unnamed
Initial amount: 0.0
 
 Akt-Takt
Compartment: unnamed
Initial amount: 0.0
 
 Takt
Compartment: unnamed
Initial amount: 0.1
 
 pAktm-Takt
Compartment: unnamed
Initial amount: 0.0
 
 Aktm-Takt
Compartment: unnamed
Initial amount: 0.0
 
 pAktm-PDK1-Takt
Compartment: unnamed
Initial amount: 0.0
 
 Aktm-PDK1-Takt
Compartment: unnamed
Initial amount: 0.0
 
  pAkt_total
Compartment: unnamed
Initial amount: 0.0
 
 pRaf1active
Compartment: unnamed
Initial amount: 0.0
 
 STAT3c
Compartment: unnamed
Initial amount: 2.0
 
 pEGF-EGFR2-STAT3c
Compartment: unnamed
Initial amount: 0.0
 
 pSTAT3c
Compartment: unnamed
Initial amount: 0.0
 
 pEGF-EGFR2-pSTAT3c
Compartment: unnamed
Initial amount: 0.0
 
 PP1
Compartment: unnamed
Initial amount: 0.5
 
 pSTAT3c-PP1
Compartment: unnamed
Initial amount: 0.0
 
 pSTAT3c-pSTAT3c-PP1
Compartment: unnamed
Initial amount: 0.0
 
 pSTAT3c-pSTAT3c
Compartment: unnamed
Initial amount: 0.0
 
 STAT3c-pSTAT3c
Compartment: unnamed
Initial amount: 0.0
 
 pSTAT3n-pSTAT3n
Compartment: unnamed
Initial amount: 0.0
 
 pSTAT3n
Compartment: unnamed
Initial amount: 0.0
 
 PP2
Compartment: unnamed
Initial amount: 0.6
 
 pSTAT3n-pSTAT3n-PP2
Compartment: unnamed
Initial amount: 0.0
 
 STAT3n-pSTAT3n
Compartment: unnamed
Initial amount: 0.0
 
 STAT3n
Compartment: unnamed
Initial amount: 0.0
 
 pSTAT3n-PP2
Compartment: unnamed
Initial amount: 0.0
 
 pEGF-EGFR2-STAT3c-cbl
Compartment: unnamed
Initial amount: 0.0
 
 pEGF-EGFR2-STAT3c-cbl-EPn
Compartment: unnamed
Initial amount: 0.0
 
 pEGF-EGFR2-PI3K-cbl
Compartment: unnamed
Initial amount: 0.0
 
 pEGF-EGFR2-PI3K-cbl-EPn
Compartment: unnamed
Initial amount: 0.0
 
r1 (2)
 
   k1
Value: 100.0
Constant
 
   k1r
Value: 0.0038
Constant
 
r2 (2)
 
   k2
Value: 10.0
Constant
 
   k2r
Value: 0.02
Constant
 
r3 (2)
 
   vmax
Value: 0.24
Constant
 
   km
Value: 13.0
Constant
 
r8 (2)
 
   k8
Value: 90.0
Constant
 
   k8r
Value: 0.6
Constant
 
r6 (2)
 
   k6
Value: 3.114
Constant
 
   k6r
Value: 0.2
Constant
 
r9 (1)
 
   k9
Value: 0.5838
Constant
 
r7 (1)
 
   k7
Value: 0.2661
Constant
 
r10 (2)
 
   k10
Value: 4.481
Constant
 
   k10r
Value: 0.3
Constant
 
r11 (2)
 
   k11
Value: 3.114
Constant
 
   k11r
Value: 0.2
Constant
 
r12 (1)
 
   k12
Value: 0.2661
Constant
 
r13 (1)
 
   k13
Value: 0.005
Constant
 
r18 (2)
 
   k18
Value: 3.0
Constant
 
   kr18
Value: 0.1
Constant
 
r19 (2)
 
   k19
Value: 10.0
Constant
 
   kr19
Value: 1.0
Constant
 
r20 (1)
 
   k20
Value: 2.661
Constant
 
r23 (2)
 
   k23
Value: 10.0
Constant
 
   kr23
Value: 0.0214
Constant
 
r26 (2)
 
   k26
Value: 0.1
Constant
 
   kr26
Value: 0.0015
Constant
 
r27 (2)
 
   k27
Value: 10.0
Constant
 
   kr27
Value: 0.045
Constant
 
r28 (2)
 
   k28
Value: 3.0
Constant
 
   kr28
Value: 0.05
Constant
 
r29 (2)
 
   k29
Value: 10.0
Constant
 
   kr29
Value: 1.0
Constant
 
r30 (1)
 
   k30
Value: 2.661
Constant
 
r31 (2)
 
   k31
Value: 10.0
Constant
 
   kr31
Value: 0.06
Constant
 
r32 (2)
 
   k32
Value: 2.734
Constant
 
   kr32
Value: 0.025
Constant
 
r35 (2)
 
   k35
Value: 202.9
Constant
 
   kr35
Value: 0.18
Constant
 
r39 (1)
 
   k39
Value: 1.67E-4
Constant
 
r36 (1)
 
   k36
Value: 0.1434
Constant
 
r38 (1)
 
   k38
Value: 0.1434
Constant
 
r37 (2)
 
   k37
Value: 202.9
Constant
 
   kr37
Value: 0.18
Constant
 
r40 (2)
 
   k40
Value: 2.854
Constant
 
   kr40
Value: 0.96
Constant
 
r41 (1)
 
   k41
Value: 7.76
Constant
 
r42 (2)
 
   k42
Value: 0.1
Constant
 
   kr42
Value: 0.01
Constant
 
r43 (2)
 
   k43
Value: 2.845
Constant
 
   kr43
Value: 0.96
Constant
 
r44 (1)
 
   k44
Value: 7.76
Constant
 
r45 (2)
 
   k45
Value: 3.114
Constant
 
   kr45
Value: 0.2
Constant
 
r46 (1)
 
   k46
Value: 2.661
Constant
 
r47 (2)
 
   k47
Value: 1.75
Constant
 
   kr47
Value: 0.05
Constant
 
r48 (1)
 
   k48
Value: 0.7624
Constant
 
r49 (2)
 
   k49
Value: 4.0
Constant
 
   kr49
Value: 0.01833
Constant
 
r50 (1)
 
   k50
Value: 3.5
Constant
 
r51 (2)
 
   k51
Value: 4.0
Constant
 
   kr51
Value: 0.01833
Constant
 
r52 (1)
 
   k52
Value: 2.9
Constant
 
r53 (2)
 
   k53
Value: 3.0
Constant
 
   kr53
Value: 0.033
Constant
 
r54 (1)
 
   k54
Value: 16.0
Constant
 
r55 (2)
 
   k55
Value: 3.0
Constant
 
   kr55
Value: 0.033
Constant
 
r56 (1)
 
   k56
Value: 5.7
Constant
 
r57 (2)
 
   k57
Value: 71.7
Constant
 
   kr57
Value: 0.2
Constant
 
r58 (1)
 
   k58
Value: 1.0
Constant
 
r59 (2)
 
   k59
Value: 14.3
Constant
 
   kr59
Value: 0.8
Constant
 
r60 (1)
 
   k60
Value: 0.058
Constant
 
r61 (2)
 
   k61
Value: 0.25
Constant
 
   kr61
Value: 0.5
Constant
 
r62 (1)
 
   k62
Value: 0.058
Constant
 
r63 (2)
 
   k63
Value: 7.0
Constant
 
   kr63
Value: 0.6
Constant
 
r64 (1)
 
   k64
Value: 0.27
Constant
 
r66 (1)
 
   k66
Value: 0.3
Constant
 
r65 (2)
 
   k65
Value: 5.0
Constant
 
   kr65
Value: 0.5
Constant
 
r67 (2)
 
   k67
Value: 8.898
Constant
 
   kr67
Value: 1.0
Constant
 
r68 (1)
 
   k68
Value: 0.0426
Constant
 
r69 (2)
 
   k69
Value: 8.898
Constant
 
   kr69
Value: 1.0
Constant
 
r70 (1)
 
   k70
Value: 0.0426
Constant
 
r71 (1)
 
   k71
Value: 0.002
Constant
 
r72 (1)
 
   k72
Value: 0.005
Constant
 
r73 (2)
 
   k73
Value: 0.2
Constant
 
   k73r
Value: 0.0025
Constant
 
r74 (2)
 
   k74
Value: 2.0
Constant
 
   k74r
Value: 0.05
Constant
 
r75 (1)
 
   k75
Value: 5.0E-4
Constant
 
r76 (2)
 
   k76
Value: 0.2
Constant
 
   k76r
Value: 0.0025
Constant
 
r77 (2)
 
   k77
Value: 2.0
Constant
 
   k77r
Value: 0.05
Constant
 
r78 (1)
 
   k78
Value: 5.0E-4
Constant
 
r79 (2)
 
   k79
Value: 0.2
Constant
 
   k79r
Value: 5.0E-4
Constant
 
r80 (2)
 
   k80
Value: 2.0
Constant
 
   kr80
Value: 0.05
Constant
 
r81 (1)
 
   k81
Value: 5.0E-4
Constant
 
r82 (2)
 
   k82
Value: 14.0
Constant
 
   kr82
Value: 0.1743
Constant
 
r83 (2)
 
   k83
Value: 33.72
Constant
 
   kr83
Value: 3.372E-4
Constant
 
r84 (2)
 
   k84
Value: 0.09
Constant
 
   kr84
Value: 0.1764
Constant
 
r85 (2)
 
   k85
Value: 1.0
Constant
 
   kr85
Value: 0.038
Constant
 
r86 (1)
 
   k86
Value: 0.595
Constant
 
r87 (2)
 
   k87
Value: 4.7E-6
Constant
 
   kr87
Value: 2.297E-6
Constant
 
r88 (2)
 
   k88
Value: 25.0
Constant
 
   kr88
Value: 3.5
Constant
 
r89 (1)
 
   k89
Value: 25.0
Constant
 
r90 (2)
 
   k90
Value: 10.0
Constant
 
   kr90
Value: 1.0
Constant
 
r91 (2)
 
   k91
Value: 10.0
Constant
 
   kr91
Value: 1.0
Constant
 
r92 (1)
 
   k92
Value: 10.0
Constant
 
r93 (2)
 
   k93
Value: 0.1
Constant
 
   kr93
Value: 0.005
Constant
 
r94 (2)
 
   k94
Value: 1.0
Constant
 
   kr94
Value: 0.001
Constant
 
r95 (1)
 
   k95
Value: 0.05
Constant
 
r96 (2)
 
   k96
Value: 0.001
Constant
 
   kr96
Value: 0.001
Constant
 
r97 (2)
 
   k97
Value: 10.0
Constant
 
   kr97
Value: 1.0
Constant
 
r98 (2)
 
   k98
Value: 10.0
Constant
 
   kr98
Value: 1.0
Constant
 
r99 (1)
 
   k99
Value: 0.05
Constant
 
r100 (2)
 
   k100
Value: 0.001
Constant
 
   kr100
Value: 0.001
Constant
 
r101 (2)
 
   k101
Value: 10.0
Constant
 
   kr101
Value: 1.0
Constant
 
r102 (1)
 
   k102
Value: 0.05
Constant
 
r103 (2)
 
   k103
Value: 0.001
Constant
 
   kr103
Value: 0.001
Constant
 
r104 (2)
 
   Kon
Value: 0.1
Constant
 
   Km
Value: 0.2
Constant
 
r105 (1)
 
   k105
Value: 1.0
Constant
 
r106 (2)
 
   k106
Value: 5.5
Constant
 
   k106r
Value: 11.74
Constant
 
r107 (1)
 
   K107
Value: 0.4
Constant
 
r108 (2)
 
   K108
Value: 5.0
Constant
 
   K108r
Value: 0.5
Constant
 
r109 (2)
 
   k109
Value: 1.0
Constant
 
   k109r
Value: 0.2
Constant
 
r110 (1)
 
   k110
Value: 0.003
Constant
 
r111 (2)
 
   k111
Value: 20.0
Constant
 
   k111r
Value: 0.1
Constant
 
r112 (2)
 
   k112
Value: 1.0
Constant
 
   k112r
Value: 0.2
Constant
 
r113 (1)
 
   k113
Value: 0.003
Constant
 
r114 (2)
 
   k114
Value: 2.0E-4
Constant
 
   k114r
Value: 0.2
Constant
 
r115 (1)
 
   k115
Value: 0.005
Constant
 
r116 (2)
 
   k116
Value: 20.0
Constant
 
   k116r
Value: 0.1
Constant
 
r117 (2)
 
   k117
Value: 1.0
Constant
 
   k117r
Value: 0.2
Constant
 
r118 (1)
 
   k118
Value: 0.005
Constant
 
r119 (2)
 
   k119
Value: 2.0E-4
Constant
 
   k119r
Value: 0.2
Constant
 
r120 (2)
 
   k120
Value: 1.0
Constant
 
   k120r
Value: 0.2
Constant
 
r121 (1)
 
   k121
Value: 0.005
Constant
 
r122 (1)
 
   k122
Value: 0.05
Constant
 
r123 (1)
 
   k123
Value: 17.0
Constant
 
r124 (2)
 
   k124
Value: 0.2
Constant
 
   kr124
Value: 0.005
Constant
 
r125 (2)
 
   k125
Value: 2.0
Constant
 
   kr125
Value: 0.05
Constant
 
r126 (1)
 
   k126
Value: 5.0E-4
Constant
 
r127 (2)
 
   k127
Value: 0.2
Constant
 
   kr127
Value: 0.005
Constant
 
r128 (2)
 
   k128
Value: 2.0
Constant
 
   kr128
Value: 0.05
Constant
 
r129 (1)
 
   k129
Value: 5.0E-4
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000453

Curator's comment: (updated: 13 May 2013 12:08:21 GMT)

The paper describes two models of EGFR signalling in normal (MODEL1304020000) and NSCLC (this model - MODEL1304020001) cells. Figure 4 of the reference publication is reproduced, where plot in red (NSCLC) can be obtained from this model (MODEL1304020001) and the plot in blue (normal cells) was obtained from MODEL1304020000.
The model was simulated using COPASI v4.8 (Build 35). The plots were obtained using Gnuplot.

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