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BIOMD0000000534 - Dwivedi2014 - Healthy Volunteer IL6 Model

 

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Reference Publication
Publication ID: 24402116
Dwivedi G, Fitz L, Hegen M, Martin SW, Harrold J, Heatherington A, Li C.
A multiscale model of interleukin-6-mediated immune regulation in Crohn's disease and its application in drug discovery and development.
CPT Pharmacometrics Syst Pharmacol 2014; 3: e89
The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.  [more]
Model
Original Model: BIOMD0000000534.origin
Submitter: Vincent Knight-Schrijver
Submission ID: MODEL1408050000
Submission Date: 05 Aug 2014 13:41:04 UTC
Last Modification Date: 04 Nov 2016 14:41:08 UTC
Creation Date: 05 Aug 2014 15:12:00 UTC
Encoders:  Vincent Knight-Schrijver
set #1
bqbiol:isPartOf Reactome REACT_27307.1
set #2
bqbiol:hasVersion Human Disease Ontology Crohn's disease
set #3
bqbiol:isVersionOf Gene Ontology interleukin-6 receptor activity
set #4
bqbiol:hasPart Gene Ontology JAK-STAT cascade
set #5
bqbiol:hasTaxon Taxonomy Homo sapiens
Notes
Dwivedi2014 - Healthy Volunteer IL6 Model
This model is comprised of four models:
Possible avenues for Interleukin-6 (IL-6) inhibition in treating Crohn's disease are compared here. Each model refers to separate ligands. The system simulates differential activity of the ligands on the signalling of IL-6. This affects Signal Transducer and Activator of Transcription 3 (STAT3) activity on the production of biomarker C-Reactive Protein (CRP) expression.
Figures referring to this Healthy Volunteer model are 2c and 2d.

This model is described in the article:

Dwivedi G, Fitz L, Hegen M, Martin SW, Harrold J, Heatherington A, Li C.
CPT Pharmacometrics Syst Pharmacol 2014; 3: e89

Abstract:

In this study, we have developed a multiscale systems model of interleukin (IL)-6-mediated immune regulation in Crohn's disease, by integrating intracellular signaling with organ-level dynamics of pharmacological markers underlying the disease. This model was linked to a general pharmacokinetic model for therapeutic monoclonal antibodies and used to comparatively study various biotherapeutic strategies targeting IL-6-mediated signaling in Crohn's disease. Our work illustrates techniques to develop mechanistic models of disease biology to study drug-system interaction. Despite a sparse training data set, predictions of the model were qualitatively validated by clinical biomarker data from a pilot trial with tocilizumab. Model-based analysis suggests that strategies targeting IL-6, IL-6R?, or the IL-6/sIL-6R? complex are less effective at suppressing pharmacological markers of Crohn's than dual targeting the IL-6/sIL-6R? complex in addition to IL-6 or IL-6R?. The potential value of multiscale system pharmacology modeling in drug discovery and development is also discussed.CPT: Pharmacometrics & Systems Pharmacology (2014) 3, e89; doi:10.1038/psp.2013.64; advance online publication 8 January 2014.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Model
Publication ID: 24402116 Submission Date: 05 Aug 2014 13:41:04 UTC Last Modification Date: 04 Nov 2016 14:41:08 UTC Creation Date: 05 Aug 2014 15:12:00 UTC
Mathematical expressions
Reactions
reaction_1 reaction_2 reaction_3 reaction_4
reaction_5 reaction_6 reaction_7 reaction_8
reaction_16 reaction_9 reaction_10 reaction_15
reaction_11 reaction_12 reaction_13 reaction_14
reaction_41 reaction_46 reaction_42 reaction_43
reaction_44 reaction_45 mwb675e13a_26c0_4b18_a8c3_0f5a62090ba4 mw64df7c9e_35da_4c7f_be56_c5dabfb060b6
mw391f3b8e_5649_4851_b2e2_782cb3e015b6 mw4a00a3a4_778f_4952_8100_2dc3cc2b7046 mw6db30657_4e56_4c3a_8575_9c67393dde4f mw6f470e13_f0e4_4294_83d8_59dd5670d10c
mwfb35eca9_7afc_4ba8_a46c_738cab57eb9f mw61d2af92_6da5_41ce_b90e_aa6f430e6ba1 mw4c099d5c_200f_474e_8ec1_59e9223a8afd mwbe8567ce_3349_4442_8b12_53cd9bc168e7
mw12a9fa7e_a273_4c1e_b970_ed33f3a9a705 mw1046000b_e1e8_4f6f_82a1_532d2aa793bb mw8e8b65a8_6830_4091_9a40_19645e8fe554 mwa812f08f_1035_42bd_82d2_72d691308f88
mwab0012ac_e5f2_4904_9893_820fd210402e mwcdc24bd4_d9e4_47fe_8300_d222d853111c mwff2ebcf1_dcf1_47b9_9cac_7306fc6f7f76 mw1c5a5ff7_5130_490f_a740_6a744ccf8a94
mw7b56053c_7256_4703_a8c3_4fd46b2c23d0 mw8be158f1_ea81_45bf_80d4_6e31cd83fe6c mwd77df15b_fed7_41a8_a3d6_b0f6c590c5f6 mw01babcdf_0f03_46b0_81b1_201cc846e361
mwae5dbb44_7de5_46ab_8c20_ac4f8956b0f0 mw432fde6e_59ab_47f0_9fb1_086433a602e3 mw41c27823_d7ee_4554_9eac_3d5beec8e854 mw50c6744c_e883_4612_8663_e38750cbad1b
mwb6a99eb5_ea4c_4733_98dd_1daf5ec6b0db mw1ce0c484_681f_4d85_8ffe_392d0c100cfa mwf913ea0b_785a_4701_ac91_b18ab5dd5a89 mw71d90b81_8211_4039_8807_12a7fe03206c
mwdf4ba845_7271_4ada_b43f_fdac83df3b5c mwb1879013_5fcd_490c_8b01_eaf84df15b9a mw30abb016_4300_4f40_a1b3_f865d0a45707 mw14d351b9_623a_48e8_a21c_854411039120
mwba7f4605_8571_439b_b3ab_eb0b43808db8 mw5be6711a_526a_4a58_80c6_d353dcabdf87 mw8b4e96ed_0bcc_4ad6_b560_366e173a6e6b mwa3cb4a9b_d628_4807_8847_bdcd9b40c7f1
mw8fb6c0a7_b05d_4c2a_8866_77eb81f063d1 mw3e76b10b_5420_4828_8c70_b91b767132d0 mw5d9fcd0c_ca08_4444_b509_2ea4777e0025 mw131e3c9d_e77d_48c0_bdbb_77b2c10aaf3d
mw14940d1f_6a1f_47cb_8170_801ba645f4c1 mwa2f4d966_ae2c_4ed2_b522_12755f12ff15 mwb62106e7_e959_4a1d_9a00_b36d4e19a48f mw700e677e_d3b6_4a97_991f_279605a9abeb
mwad648b6c_45ca_4f41_9747_06db1f6060fc mw2ae288ab_7d03_4a84_a024_c711ad2b77e6 mw9629d028_fcc0_4886_9e4d_36eecdb0381d  
Rules
Assignment Rule (variable: geneProduct) Assignment Rule (variable: CRP)    
Events
Week0 Week4 Week8 Week12
Physical entities
Compartments Species
serum IL6 sgp130 sR_IL6_sgp130
CRP sR sR_IL6
Ab Ab_IL6 Ab_sR_IL6
     
liver gp130 R_IL6_gp130 sR_IL6
R IL6 R_IL6
Ractive STAT3 pSTAT3
CRP sR CRPExtracellular
sgp130 sR_IL6_sgp130 Ab_sR_IL6
Ab_IL6 Ab  
gut sR_IL6 gp130 R_IL6_gp130
Ractive STAT3 pSTAT3
geneProduct sR IL6
sgp130 sR_IL6_sgp130 Ab
Ab_IL6 Ab_sR_IL6  
peripheral Ab    
Global parameters
kRLOn kRLOff kgp130On kgp130Off
kRAct kRint kRsynth kRintBasal
ksynthIL6 kdegIL6 kdegCRP KmSTATDephos
VmSTATDephos VmRDephos KmRDephos kcatSTATPhos
KmSTATPhos KmProtSynth VmProtSynth kCRPSecretion
ksynthCRP ksynthsR kdegsR ksynthsgp130
kdegsgp130 ksynthIL6Gut kdegIL6Gut kdistTissueToSerum
kdistSerumToTissue kRShedding kintActiveR kIL6AbBind
kIL6AbUnbind kAbSerumToLiver kAbLiverToSerum kAbSerumToGut
kAbGutToSerum VSerum VLiver VGut
VPeriph QSerumLiver QSerumGut QSerumPeriph
kAbSerumToPeriph kAbPeriphToSerum kdegAb infusionTime
Dose Initial for Ab Initial for Dose  
Reactions (71)
 
 reaction_1 [sR] + [IL6] ↔ [sR_IL6];   {sR_IL6} , {sR} , {IL6}
 
 reaction_2 [sR_IL6] + [sgp130] ↔ [sR_IL6_sgp130];   {sR_IL6} , {sR_IL6_sgp130} , {sgp130}
 
 reaction_3  → [IL6];  
 
 reaction_4 [IL6] → ;   {IL6}
 
 reaction_5 [CRP] → ;   {CRP}
 
 reaction_6 [sR_IL6] + [gp130] ↔ [R_IL6_gp130];   {sR_IL6} , {gp130} , {R_IL6_gp130}
 
 reaction_7 [R] + [IL6] ↔ [R_IL6];   {IL6} , {R} , {R_IL6}
 
 reaction_8 [R_IL6] + [gp130] ↔ [R_IL6_gp130];   {R_IL6} , {gp130} , {R_IL6_gp130}
 
 reaction_16 [R_IL6_gp130] → [Ractive];   {R_IL6_gp130}
 
 reaction_9 [STAT3] + [Ractive] → [pSTAT3] + [Ractive];   {Ractive} , {STAT3}
 
 reaction_10 [pSTAT3] → [STAT3];   {pSTAT3}
 
 reaction_15 [R] → ;   {R}
 
 reaction_11 [R_IL6] → ;   {R_IL6}
 
 reaction_12 [R_IL6_gp130] → ;   {R_IL6_gp130}
 
 reaction_13 [Ractive] → ;   {Ractive}
 
 reaction_14  → [R];  
 
 reaction_41 [sR_IL6] + [gp130] ↔ [R_IL6_gp130];   {sR_IL6} , {R_IL6_gp130} , {gp130}
 
 reaction_46 [R_IL6_gp130] → [Ractive];   {R_IL6_gp130}
 
 reaction_42 [STAT3] + [Ractive] → [pSTAT3] + [Ractive];   {STAT3} , {Ractive}
 
 reaction_43 [pSTAT3] → [STAT3];   {pSTAT3}
 
 reaction_44 [R_IL6_gp130] → ;   {R_IL6_gp130}
 
 reaction_45 [Ractive] → ;   {Ractive}
 
 mwb675e13a_26c0_4b18_a8c3_0f5a62090ba4 [Ractive] → [R_IL6_gp130];   {Ractive}
 
 mw64df7c9e_35da_4c7f_be56_c5dabfb060b6 [Ractive] → [R_IL6_gp130];   {Ractive}
 
 mw391f3b8e_5649_4851_b2e2_782cb3e015b6  → [gp130];  
 
 mw4a00a3a4_778f_4952_8100_2dc3cc2b7046 [gp130] → ;   {gp130}
 
 mw6db30657_4e56_4c3a_8575_9c67393dde4f  → [gp130];  
 
 mw6f470e13_f0e4_4294_83d8_59dd5670d10c [gp130] → ;   {gp130}
 
 mwfb35eca9_7afc_4ba8_a46c_738cab57eb9f [sR] ↔ [sR];   {sR} , {sR}
 
 mw61d2af92_6da5_41ce_b90e_aa6f430e6ba1 [IL6] ↔ [IL6];   {IL6} , {IL6}
 
 mw4c099d5c_200f_474e_8ec1_59e9223a8afd [sR] + [IL6] ↔ [sR_IL6];   {IL6} , {sR_IL6} , {sR}
 
 mwbe8567ce_3349_4442_8b12_53cd9bc168e7 [sR_IL6] ↔ [sR_IL6];   {sR_IL6} , {sR_IL6}
 
 mw12a9fa7e_a273_4c1e_b970_ed33f3a9a705 [sR] ↔ [sR];   {sR} , {sR}
 
 mw1046000b_e1e8_4f6f_82a1_532d2aa793bb [IL6] ↔ [IL6];   {IL6} , {IL6}
 
 mw8e8b65a8_6830_4091_9a40_19645e8fe554 [sR_IL6] ↔ [sR_IL6];   {sR_IL6} , {sR_IL6}
 
 mwa812f08f_1035_42bd_82d2_72d691308f88 [sR] + [IL6] ↔ [sR_IL6];   {IL6} , {sR} , {sR_IL6}
 
 mwab0012ac_e5f2_4904_9893_820fd210402e [CRP] → [CRPExtracellular];   {CRP}
 
 mwcdc24bd4_d9e4_47fe_8300_d222d853111c [CRP] ↔ [CRPExtracellular];   {CRP} , {CRPExtracellular}
 
 mwff2ebcf1_dcf1_47b9_9cac_7306fc6f7f76  → [CRP];  
 
 mw1c5a5ff7_5130_490f_a740_6a744ccf8a94 [sgp130] ↔ [sgp130];   {sgp130} , {sgp130}
 
 mw7b56053c_7256_4703_a8c3_4fd46b2c23d0 [sgp130] ↔ [sgp130];   {sgp130} , {sgp130}
 
 mw8be158f1_ea81_45bf_80d4_6e31cd83fe6c [sgp130] + [sR_IL6] ↔ [sR_IL6_sgp130];   {sR_IL6_sgp130} , {sR_IL6} , {sgp130}
 
 mwd77df15b_fed7_41a8_a3d6_b0f6c590c5f6 [sR_IL6] + [sgp130] ↔ [sR_IL6_sgp130];   {sgp130} , {sR_IL6} , {sR_IL6_sgp130}
 
 mw01babcdf_0f03_46b0_81b1_201cc846e361 [sR_IL6_sgp130] ↔ [sR_IL6_sgp130];   {sR_IL6_sgp130} , {sR_IL6_sgp130}
 
 mwae5dbb44_7de5_46ab_8c20_ac4f8956b0f0 [sR_IL6_sgp130] ↔ [sR_IL6_sgp130];   {sR_IL6_sgp130} , {sR_IL6_sgp130}
 
 mw432fde6e_59ab_47f0_9fb1_086433a602e3  → [sR];  
 
 mw41c27823_d7ee_4554_9eac_3d5beec8e854 [sR] → ;   {sR}
 
 mw50c6744c_e883_4612_8663_e38750cbad1b  → [sgp130];  
 
 mwb6a99eb5_ea4c_4733_98dd_1daf5ec6b0db [sgp130] → ;   {sgp130}
 
 mw1ce0c484_681f_4d85_8ffe_392d0c100cfa  → [IL6];  
 
 mwf913ea0b_785a_4701_ac91_b18ab5dd5a89 [IL6] → ;   {IL6}
 
 mw71d90b81_8211_4039_8807_12a7fe03206c [CRP] → [sR] + [CRP];   {CRP}
 
 mwdf4ba845_7271_4ada_b43f_fdac83df3b5c [Ab] ↔ [Ab];   {Ab} , {Ab}
 
 mwb1879013_5fcd_490c_8b01_eaf84df15b9a [IL6] + [Ab] ↔ [Ab_IL6];   {Ab_IL6} , {Ab} , {IL6}
 
 mw30abb016_4300_4f40_a1b3_f865d0a45707 [Ab_IL6] → ;   {Ab_IL6}
 
 mw14d351b9_623a_48e8_a21c_854411039120 [Ab_sR_IL6] → ;   {Ab_sR_IL6}
 
 mwba7f4605_8571_439b_b3ab_eb0b43808db8 [Ab] → ;   {Ab}
 
 mw5be6711a_526a_4a58_80c6_d353dcabdf87 [Ab_sR_IL6] → ;   {Ab_sR_IL6}
 
 mw8b4e96ed_0bcc_4ad6_b560_366e173a6e6b [Ab_IL6] → ;   {Ab_IL6}
 
 mwa3cb4a9b_d628_4807_8847_bdcd9b40c7f1 [Ab] + [IL6] ↔ [Ab_IL6];   {IL6} , {Ab_IL6} , {Ab}
 
 mw8fb6c0a7_b05d_4c2a_8866_77eb81f063d1 [Ab] + [IL6] ↔ [Ab_IL6];   {IL6} , {Ab} , {Ab_IL6}
 
 mw3e76b10b_5420_4828_8c70_b91b767132d0 [Ab_IL6] → ;   {Ab_IL6}
 
 mw5d9fcd0c_ca08_4444_b509_2ea4777e0025 [Ab_sR_IL6] → ;   {Ab_sR_IL6}
 
 mw131e3c9d_e77d_48c0_bdbb_77b2c10aaf3d [Ab] ↔ [Ab];   {Ab} , {Ab}
 
 mw14940d1f_6a1f_47cb_8170_801ba645f4c1 [Ab] ↔ [Ab];   {Ab} , {Ab}
 
 mwa2f4d966_ae2c_4ed2_b522_12755f12ff15 [Ab_IL6] ↔ [Ab_IL6];   {Ab_IL6} , {Ab_IL6}
 
 mwb62106e7_e959_4a1d_9a00_b36d4e19a48f [Ab_sR_IL6] ↔ [Ab_sR_IL6];   {Ab_sR_IL6} , {Ab_sR_IL6}
 
 mw700e677e_d3b6_4a97_991f_279605a9abeb [Ab_IL6] ↔ [Ab_IL6];   {Ab_IL6} , {Ab_IL6}
 
 mwad648b6c_45ca_4f41_9747_06db1f6060fc [Ab_sR_IL6] ↔ [Ab_sR_IL6];   {Ab_sR_IL6} , {Ab_sR_IL6}
 
 mw2ae288ab_7d03_4a84_a024_c711ad2b77e6 [Ab] → ;   {Ab}
 
 mw9629d028_fcc0_4886_9e4d_36eecdb0381d [Ab] → ;   {Ab}
 
Rules (2)
 
 Assignment Rule (name: mw0083d743_836f_4238_a17f_4602193d5bc0) geneProduct = mw92d854a7_8aaf_458e_b5e2_20a63ce9b654*mw48867e93_f170_44e8_ac7a_185b23e1bf3b/(mw08950572_81b0_4570_b2e4_b9c3462c1425+mw48867e93_f170_44e8_ac7a_185b23e1bf3b)
 
 Assignment Rule (name: mwd5313618_89eb_4c8c_bc82_66f10f966349) CRP = mw92d854a7_8aaf_458e_b5e2_20a63ce9b654*mw39c2e431_fdc3_4964_be29_6ca856620b1b/(mw08950572_81b0_4570_b2e4_b9c3462c1425+mw39c2e431_fdc3_4964_be29_6ca856620b1b)
 
Events (4)
 
 Week0
Ab = mwf345ed7a_0622_403c_b816_c8749a2c9ded+ModelValue_48*2.346
 
 Week4
Ab = mwf345ed7a_0622_403c_b816_c8749a2c9ded+ModelValue_48*2.346
 
 Week8
Ab = mwf345ed7a_0622_403c_b816_c8749a2c9ded+ModelValue_48*2.346
 
 Week12
Ab = Metabolite_6+ModelValue_48*2.346
 
Functions (53)
 
 Function for reaction_1 lambda(kRLOff, kRLOn, mw03db56ac_8dc6_4931_ae82_fef706d2ee3d, mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc, mw53ffe9e6_beef_45c4_90a5_a79197ed506e, mwf626e95e_543f_41e4_aad4_c6bf60ab345b, (kRLOn*mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc*mwf626e95e_543f_41e4_aad4_c6bf60ab345b-kRLOff*mw03db56ac_8dc6_4931_ae82_fef706d2ee3d)/mw53ffe9e6_beef_45c4_90a5_a79197ed506e)
 
 Function for reaction_2 lambda(kgp130Off, kgp130On, mw03db56ac_8dc6_4931_ae82_fef706d2ee3d, mw53ffe9e6_beef_45c4_90a5_a79197ed506e, mw810ff751_fa4e_4143_bd50_169b3e325e1e, mwbbbce920_e8dd_4320_9386_fc94bfb2fc99, (kgp130On*mw03db56ac_8dc6_4931_ae82_fef706d2ee3d*mwbbbce920_e8dd_4320_9386_fc94bfb2fc99-kgp130Off*mw810ff751_fa4e_4143_bd50_169b3e325e1e)/mw53ffe9e6_beef_45c4_90a5_a79197ed506e)
 
 Function for reaction_3 lambda(kIL6Synth, mw53ffe9e6_beef_45c4_90a5_a79197ed506e, kIL6Synth/mw53ffe9e6_beef_45c4_90a5_a79197ed506e)
 
 Function for reaction_4 lambda(kIL6Decay, mw53ffe9e6_beef_45c4_90a5_a79197ed506e, mwf626e95e_543f_41e4_aad4_c6bf60ab345b, kIL6Decay*mwf626e95e_543f_41e4_aad4_c6bf60ab345b/mw53ffe9e6_beef_45c4_90a5_a79197ed506e)
 
 Function for reaction_5 lambda(kCRPDecay, mw114aa90f_5f5b_4fe8_9406_361c8489b6a1, mw53ffe9e6_beef_45c4_90a5_a79197ed506e, kCRPDecay*mw114aa90f_5f5b_4fe8_9406_361c8489b6a1/mw53ffe9e6_beef_45c4_90a5_a79197ed506e)
 
 Function for reaction_6 lambda(kgp130Off, kgp130On, mw4638f126_8cb8_4021_ab41_6ae195743ba0, mw80848184_e2dd_47ce_86d7_7a21479342bd, mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e, mwd2d9d93a_3bd1_4f17_bac1_baba9ef2d55a, (kgp130On*mw4638f126_8cb8_4021_ab41_6ae195743ba0*mw80848184_e2dd_47ce_86d7_7a21479342bd-kgp130Off*mwd2d9d93a_3bd1_4f17_bac1_baba9ef2d55a)/mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e)
 
 Function for reaction_7 lambda(kRLOff, kRLOn, mw0adf3eb4_a196_4c48_b10d_4e9e9faaf9e1, mw10315fa3_6f13_4618_bda8_a8694bd3c374, mw7d86cc23_a1af_44c3_bdb9_71e9b1bb2a83, mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e, (kRLOn*mw10315fa3_6f13_4618_bda8_a8694bd3c374*mw0adf3eb4_a196_4c48_b10d_4e9e9faaf9e1-kRLOff*mw7d86cc23_a1af_44c3_bdb9_71e9b1bb2a83)/mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e)
 
 Function for reaction_8 lambda(kgp130Off, kgp130On, mw7d86cc23_a1af_44c3_bdb9_71e9b1bb2a83, mw80848184_e2dd_47ce_86d7_7a21479342bd, mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e, mwd2d9d93a_3bd1_4f17_bac1_baba9ef2d55a, (kgp130On*mw7d86cc23_a1af_44c3_bdb9_71e9b1bb2a83*mw80848184_e2dd_47ce_86d7_7a21479342bd-kgp130Off*mwd2d9d93a_3bd1_4f17_bac1_baba9ef2d55a)/mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e)
 
 Function for reaction_16 lambda(kRAct, mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e, mwd2d9d93a_3bd1_4f17_bac1_baba9ef2d55a, kRAct*mwd2d9d93a_3bd1_4f17_bac1_baba9ef2d55a/mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e)
 
 Function for reaction_9 lambda(mw0eb6c959_d408_45a0_a450_928b8c5876bb, mw42054cd7_17af_46da_970c_7f99151906ad, mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e, mw9442cd0e_4d7c_4ba6_a695_f84919bdf569, mwe8fc1900_f07d_468b_b5c8_15400a583c3d, mw9442cd0e_4d7c_4ba6_a695_f84919bdf569*mw0eb6c959_d408_45a0_a450_928b8c5876bb*mw42054cd7_17af_46da_970c_7f99151906ad/(mwe8fc1900_f07d_468b_b5c8_15400a583c3d+mw42054cd7_17af_46da_970c_7f99151906ad)/mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e)
 
 Function for reaction_10 lambda(mw39c2e431_fdc3_4964_be29_6ca856620b1b, mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e, mwd36b0261_2480_4cab_9222_2cf8fb0e65dc, mwfd291862_195f_4979_94b5_b4e5ae1b7d52, mwd36b0261_2480_4cab_9222_2cf8fb0e65dc*mw39c2e431_fdc3_4964_be29_6ca856620b1b/(mwfd291862_195f_4979_94b5_b4e5ae1b7d52+mw39c2e431_fdc3_4964_be29_6ca856620b1b)/mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e)
 
 Function for reaction_15 lambda(kRdeg, mw10315fa3_6f13_4618_bda8_a8694bd3c374, mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e, kRdeg*mw10315fa3_6f13_4618_bda8_a8694bd3c374/mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e)
 
 Function for reaction_11 lambda(kRint, mw7d86cc23_a1af_44c3_bdb9_71e9b1bb2a83, mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e, kRint*mw7d86cc23_a1af_44c3_bdb9_71e9b1bb2a83/mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e)
 
 Function for reaction_12 lambda(kRint, mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e, mwd2d9d93a_3bd1_4f17_bac1_baba9ef2d55a, kRint*mwd2d9d93a_3bd1_4f17_bac1_baba9ef2d55a/mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e)
 
 Function for reaction_13 lambda(mw0eb6c959_d408_45a0_a450_928b8c5876bb, mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e, mwf44f7f27_5bb1_4c7f_8964_560fa5e1743a, mwf44f7f27_5bb1_4c7f_8964_560fa5e1743a*mw0eb6c959_d408_45a0_a450_928b8c5876bb/mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e)
 
 Function for reaction_14 lambda(kRsynth, mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e, kRsynth/mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e)
 
 Function for reaction_41 lambda(kgp130Off, kgp130On, mw7becb5fe_8da8_4285_a821_0d77ad811b62, mw824bc3d4_1ac3_4912_9b51_8f14ff1c96b9, mw8c9107e6_f51d_442d_b2dc_2bfdbb8482ca, mwe9501423_9fb4_494b_b5b6_288f3fcb17b5, (kgp130On*mw7becb5fe_8da8_4285_a821_0d77ad811b62*mw8c9107e6_f51d_442d_b2dc_2bfdbb8482ca-kgp130Off*mw824bc3d4_1ac3_4912_9b51_8f14ff1c96b9)/mwe9501423_9fb4_494b_b5b6_288f3fcb17b5)
 
 Function for reaction_46 lambda(kRAct, mw824bc3d4_1ac3_4912_9b51_8f14ff1c96b9, mwe9501423_9fb4_494b_b5b6_288f3fcb17b5, kRAct*mw824bc3d4_1ac3_4912_9b51_8f14ff1c96b9/mwe9501423_9fb4_494b_b5b6_288f3fcb17b5)
 
 Function for reaction_42 lambda(mw2b255f94_8018_4b99_bde8_918eeac45446, mw6cce2109_0e32_4dd9_98ec_41173e8ef07d, mw9442cd0e_4d7c_4ba6_a695_f84919bdf569, mwe8fc1900_f07d_468b_b5c8_15400a583c3d, mwe9501423_9fb4_494b_b5b6_288f3fcb17b5, mw9442cd0e_4d7c_4ba6_a695_f84919bdf569*mw6cce2109_0e32_4dd9_98ec_41173e8ef07d*mw2b255f94_8018_4b99_bde8_918eeac45446/(mwe8fc1900_f07d_468b_b5c8_15400a583c3d+mw2b255f94_8018_4b99_bde8_918eeac45446)/mwe9501423_9fb4_494b_b5b6_288f3fcb17b5)
 
 Function for reaction_43 lambda(mw48867e93_f170_44e8_ac7a_185b23e1bf3b, mwd36b0261_2480_4cab_9222_2cf8fb0e65dc, mwe9501423_9fb4_494b_b5b6_288f3fcb17b5, mwfd291862_195f_4979_94b5_b4e5ae1b7d52, mwd36b0261_2480_4cab_9222_2cf8fb0e65dc*mw48867e93_f170_44e8_ac7a_185b23e1bf3b/(mwfd291862_195f_4979_94b5_b4e5ae1b7d52+mw48867e93_f170_44e8_ac7a_185b23e1bf3b)/mwe9501423_9fb4_494b_b5b6_288f3fcb17b5)
 
 Function for reaction_44 lambda(kRint, mw824bc3d4_1ac3_4912_9b51_8f14ff1c96b9, mwe9501423_9fb4_494b_b5b6_288f3fcb17b5, kRint*mw824bc3d4_1ac3_4912_9b51_8f14ff1c96b9/mwe9501423_9fb4_494b_b5b6_288f3fcb17b5)
 
 Function for reaction_45 lambda(mw6cce2109_0e32_4dd9_98ec_41173e8ef07d, mwe9501423_9fb4_494b_b5b6_288f3fcb17b5, mwf44f7f27_5bb1_4c7f_8964_560fa5e1743a, mwf44f7f27_5bb1_4c7f_8964_560fa5e1743a*mw6cce2109_0e32_4dd9_98ec_41173e8ef07d/mwe9501423_9fb4_494b_b5b6_288f3fcb17b5)
 
 Function for mwb675e13a_26c0_4b18_a8c3_0f5a62090ba4 lambda(mw0eb6c959_d408_45a0_a450_928b8c5876bb, mw1667a8e0_9d20_4e59_ba51_596148aba787, mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e, mwfcf06900_5f2f_4bb3_bb1f_12023612b8a8, mw1667a8e0_9d20_4e59_ba51_596148aba787*mw0eb6c959_d408_45a0_a450_928b8c5876bb/(mwfcf06900_5f2f_4bb3_bb1f_12023612b8a8+mw0eb6c959_d408_45a0_a450_928b8c5876bb)/mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e)
 
 Function for mw64df7c9e_35da_4c7f_be56_c5dabfb060b6 lambda(mw1667a8e0_9d20_4e59_ba51_596148aba787, mw6cce2109_0e32_4dd9_98ec_41173e8ef07d, mwe9501423_9fb4_494b_b5b6_288f3fcb17b5, mwfcf06900_5f2f_4bb3_bb1f_12023612b8a8, mw1667a8e0_9d20_4e59_ba51_596148aba787*mw6cce2109_0e32_4dd9_98ec_41173e8ef07d/(mwfcf06900_5f2f_4bb3_bb1f_12023612b8a8+mw6cce2109_0e32_4dd9_98ec_41173e8ef07d)/mwe9501423_9fb4_494b_b5b6_288f3fcb17b5)
 
 Function for mw391f3b8e_5649_4851_b2e2_782cb3e015b6 lambda(kRsynth, mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e, kRsynth/mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e)
 
 Function for mw4a00a3a4_778f_4952_8100_2dc3cc2b7046 lambda(kRdeg, mw80848184_e2dd_47ce_86d7_7a21479342bd, mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e, kRdeg*mw80848184_e2dd_47ce_86d7_7a21479342bd/mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e)
 
 Function for mw6db30657_4e56_4c3a_8575_9c67393dde4f lambda(kRsynth, mwe9501423_9fb4_494b_b5b6_288f3fcb17b5, kRsynth/mwe9501423_9fb4_494b_b5b6_288f3fcb17b5)
 
 Function for mw6f470e13_f0e4_4294_83d8_59dd5670d10c lambda(kRdeg, mw8c9107e6_f51d_442d_b2dc_2bfdbb8482ca, mwe9501423_9fb4_494b_b5b6_288f3fcb17b5, kRdeg*mw8c9107e6_f51d_442d_b2dc_2bfdbb8482ca/mwe9501423_9fb4_494b_b5b6_288f3fcb17b5)
 
 Function for mw4c099d5c_200f_474e_8ec1_59e9223a8afd lambda(kRLOff, kRLOn, mw2c9b0499_3325_4394_8af3_bbf653a944a0, mw7becb5fe_8da8_4285_a821_0d77ad811b62, mwd31f52cc_04e7_40e0_885f_c7b2d9e62215, mwe9501423_9fb4_494b_b5b6_288f3fcb17b5, (kRLOn*mwd31f52cc_04e7_40e0_885f_c7b2d9e62215*mw2c9b0499_3325_4394_8af3_bbf653a944a0-kRLOff*mw7becb5fe_8da8_4285_a821_0d77ad811b62)/mwe9501423_9fb4_494b_b5b6_288f3fcb17b5)
 
 Function for mwa812f08f_1035_42bd_82d2_72d691308f88 lambda(kRLOff, kRLOn, mw0adf3eb4_a196_4c48_b10d_4e9e9faaf9e1, mw2e464cf3_a09c_4b7c_9f3c_06720016a48e, mw4638f126_8cb8_4021_ab41_6ae195743ba0, mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e, (kRLOn*mw2e464cf3_a09c_4b7c_9f3c_06720016a48e*mw0adf3eb4_a196_4c48_b10d_4e9e9faaf9e1-kRLOff*mw4638f126_8cb8_4021_ab41_6ae195743ba0)/mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e)
 
 Function for mwab0012ac_e5f2_4904_9893_820fd210402e lambda(mw862f1480_c60c_4863_a565_b2c1c77e238e, mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e, mwd5313618_89eb_4c8c_bc82_66f10f966349, mw862f1480_c60c_4863_a565_b2c1c77e238e*mwd5313618_89eb_4c8c_bc82_66f10f966349/mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e)
 
 Function for mwff2ebcf1_dcf1_47b9_9cac_7306fc6f7f76 lambda(mw53ffe9e6_beef_45c4_90a5_a79197ed506e, mw65c85954_5ca0_4df2_9e22_ff2aa3fbe3f1, mw65c85954_5ca0_4df2_9e22_ff2aa3fbe3f1/mw53ffe9e6_beef_45c4_90a5_a79197ed506e)
 
 Function for mw8be158f1_ea81_45bf_80d4_6e31cd83fe6c lambda(kgp130Off, kgp130On, mw6335d5d7_c7b0_4bc0_b883_f7ee4915c2c3, mw7becb5fe_8da8_4285_a821_0d77ad811b62, mwd65b5b39_dc1b_4e77_a999_67277a880e5e, mwe9501423_9fb4_494b_b5b6_288f3fcb17b5, (kgp130On*mwd65b5b39_dc1b_4e77_a999_67277a880e5e*mw7becb5fe_8da8_4285_a821_0d77ad811b62-kgp130Off*mw6335d5d7_c7b0_4bc0_b883_f7ee4915c2c3)/mwe9501423_9fb4_494b_b5b6_288f3fcb17b5)
 
 Function for mwd77df15b_fed7_41a8_a3d6_b0f6c590c5f6 lambda(kgp130Off, kgp130On, mw147d30ec_478e_4090_b496_128a131d29eb, mw4638f126_8cb8_4021_ab41_6ae195743ba0, mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e, mwab41493c_6349_45f1_a226_3030cfed0e06, (kgp130On*mw4638f126_8cb8_4021_ab41_6ae195743ba0*mw147d30ec_478e_4090_b496_128a131d29eb-kgp130Off*mwab41493c_6349_45f1_a226_3030cfed0e06)/mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e)
 
 Function for mw432fde6e_59ab_47f0_9fb1_086433a602e3 lambda(mw53ffe9e6_beef_45c4_90a5_a79197ed506e, mwc4c58db7_5535_4590_aaa5_bbc8ed53cdab, mwc4c58db7_5535_4590_aaa5_bbc8ed53cdab/mw53ffe9e6_beef_45c4_90a5_a79197ed506e)
 
 Function for mw41c27823_d7ee_4554_9eac_3d5beec8e854 lambda(mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc, mw53ffe9e6_beef_45c4_90a5_a79197ed506e, mw88a75379_f9a1_4acc_baeb_94c32bb736a5, mw88a75379_f9a1_4acc_baeb_94c32bb736a5*mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc/mw53ffe9e6_beef_45c4_90a5_a79197ed506e)
 
 Function for mw50c6744c_e883_4612_8663_e38750cbad1b lambda(mw1f41474c_c399_4a60_a53a_9926dd092e8d, mw53ffe9e6_beef_45c4_90a5_a79197ed506e, mw1f41474c_c399_4a60_a53a_9926dd092e8d/mw53ffe9e6_beef_45c4_90a5_a79197ed506e)
 
 Function for mwb6a99eb5_ea4c_4733_98dd_1daf5ec6b0db lambda(mw53ffe9e6_beef_45c4_90a5_a79197ed506e, mwbbbce920_e8dd_4320_9386_fc94bfb2fc99, mwbcb5a310_9b67_405e_89ec_43d25e8cc93d, mwbcb5a310_9b67_405e_89ec_43d25e8cc93d*mwbbbce920_e8dd_4320_9386_fc94bfb2fc99/mw53ffe9e6_beef_45c4_90a5_a79197ed506e)
 
 Function for mw1ce0c484_681f_4d85_8ffe_392d0c100cfa lambda(mwa8d72918_f6c2_4d81_bf3b_fc2b464d5e69, mwe9501423_9fb4_494b_b5b6_288f3fcb17b5, mwa8d72918_f6c2_4d81_bf3b_fc2b464d5e69/mwe9501423_9fb4_494b_b5b6_288f3fcb17b5)
 
 Function for mwf913ea0b_785a_4701_ac91_b18ab5dd5a89 lambda(mw06241335_b5f2_47ed_bdcc_ef77b68a2b98, mw2c9b0499_3325_4394_8af3_bbf653a944a0, mwe9501423_9fb4_494b_b5b6_288f3fcb17b5, mw06241335_b5f2_47ed_bdcc_ef77b68a2b98*mw2c9b0499_3325_4394_8af3_bbf653a944a0/mwe9501423_9fb4_494b_b5b6_288f3fcb17b5)
 
 Function for mw71d90b81_8211_4039_8807_12a7fe03206c lambda(mw114aa90f_5f5b_4fe8_9406_361c8489b6a1, mw53ffe9e6_beef_45c4_90a5_a79197ed506e, mw5832a2dc_ee18_44df_aa59_ccb21cb74df2, mw5832a2dc_ee18_44df_aa59_ccb21cb74df2*mw114aa90f_5f5b_4fe8_9406_361c8489b6a1/mw53ffe9e6_beef_45c4_90a5_a79197ed506e)
 
 Function for mw30abb016_4300_4f40_a1b3_f865d0a45707 lambda(mw1da111f2_a036_4392_8512_015005bdcbb7, mw53ffe9e6_beef_45c4_90a5_a79197ed506e, mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30, mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30*mw1da111f2_a036_4392_8512_015005bdcbb7/mw53ffe9e6_beef_45c4_90a5_a79197ed506e)
 
 Function for mwba7f4605_8571_439b_b3ab_eb0b43808db8 lambda(mw53ffe9e6_beef_45c4_90a5_a79197ed506e, mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30, mwf345ed7a_0622_403c_b816_c8749a2c9ded, mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30*mwf345ed7a_0622_403c_b816_c8749a2c9ded/mw53ffe9e6_beef_45c4_90a5_a79197ed506e)
 
 Function for mw8b4e96ed_0bcc_4ad6_b560_366e173a6e6b lambda(mw5d764bb8_5693_4ac8_9557_f65992cc5eb0, mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30, mwe9501423_9fb4_494b_b5b6_288f3fcb17b5, mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30*mw5d764bb8_5693_4ac8_9557_f65992cc5eb0/mwe9501423_9fb4_494b_b5b6_288f3fcb17b5)
 
 Function for mw3e76b10b_5420_4828_8c70_b91b767132d0 lambda(mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e, mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30, mwf405687b_7401_44ec_a0d6_4a2b35c13e8a, mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30*mwf405687b_7401_44ec_a0d6_4a2b35c13e8a/mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e)
 
 Function for mw2ae288ab_7d03_4a84_a024_c711ad2b77e6 lambda(mw3667a5e1_02c9_44a0_acb4_b0431faa822d, mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e, mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30, mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30*mw3667a5e1_02c9_44a0_acb4_b0431faa822d/mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e)
 
 Function for mw9629d028_fcc0_4886_9e4d_36eecdb0381d lambda(mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30, mwe9501423_9fb4_494b_b5b6_288f3fcb17b5, mwf7796221_1fea_4274_a93e_c00adbf5778c, mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30*mwf7796221_1fea_4274_a93e_c00adbf5778c/mwe9501423_9fb4_494b_b5b6_288f3fcb17b5)
 
 Function for mw5d9fcd0c_ca08_4444_b509_2ea4777e0025 lambda(mw1d9426a3_e1e9_49e0_ad77_eb6833be398a, mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e, mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30, mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30*mw1d9426a3_e1e9_49e0_ad77_eb6833be398a/mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e)
 
 Function for mwb1879013_5fcd_490c_8b01_eaf84df15b9a [1] lambda(mw1c4bc9c3_52ad_4ef7_bf7f_97b0e2101ead, mw1da111f2_a036_4392_8512_015005bdcbb7, mw53ffe9e6_beef_45c4_90a5_a79197ed506e, mwa09d6284_843e_404e_abbb_052fbb535197, mwf345ed7a_0622_403c_b816_c8749a2c9ded, mwf626e95e_543f_41e4_aad4_c6bf60ab345b, (mwa09d6284_843e_404e_abbb_052fbb535197*mwf626e95e_543f_41e4_aad4_c6bf60ab345b*mwf345ed7a_0622_403c_b816_c8749a2c9ded-mw1c4bc9c3_52ad_4ef7_bf7f_97b0e2101ead*mw1da111f2_a036_4392_8512_015005bdcbb7)/mw53ffe9e6_beef_45c4_90a5_a79197ed506e)
 
 Function for mw14d351b9_623a_48e8_a21c_854411039120 lambda(mw53ffe9e6_beef_45c4_90a5_a79197ed506e, mwa2d8dd1c_bb9a_4552_8738_e24671651c1d, mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30, mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30*mwa2d8dd1c_bb9a_4552_8738_e24671651c1d/mw53ffe9e6_beef_45c4_90a5_a79197ed506e)
 
 Function for mw8fb6c0a7_b05d_4c2a_8866_77eb81f063d1 [1] lambda(mw0adf3eb4_a196_4c48_b10d_4e9e9faaf9e1, mw1c4bc9c3_52ad_4ef7_bf7f_97b0e2101ead, mw3667a5e1_02c9_44a0_acb4_b0431faa822d, mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e, mwa09d6284_843e_404e_abbb_052fbb535197, mwf405687b_7401_44ec_a0d6_4a2b35c13e8a, (mwa09d6284_843e_404e_abbb_052fbb535197*mw3667a5e1_02c9_44a0_acb4_b0431faa822d*mw0adf3eb4_a196_4c48_b10d_4e9e9faaf9e1-mw1c4bc9c3_52ad_4ef7_bf7f_97b0e2101ead*mwf405687b_7401_44ec_a0d6_4a2b35c13e8a)/mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e)
 
 Function for mwa3cb4a9b_d628_4807_8847_bdcd9b40c7f1 [1] lambda(mw1c4bc9c3_52ad_4ef7_bf7f_97b0e2101ead, mw2c9b0499_3325_4394_8af3_bbf653a944a0, mw5d764bb8_5693_4ac8_9557_f65992cc5eb0, mwa09d6284_843e_404e_abbb_052fbb535197, mwe9501423_9fb4_494b_b5b6_288f3fcb17b5, mwf7796221_1fea_4274_a93e_c00adbf5778c, (mwa09d6284_843e_404e_abbb_052fbb535197*mwf7796221_1fea_4274_a93e_c00adbf5778c*mw2c9b0499_3325_4394_8af3_bbf653a944a0-mw1c4bc9c3_52ad_4ef7_bf7f_97b0e2101ead*mw5d764bb8_5693_4ac8_9557_f65992cc5eb0)/mwe9501423_9fb4_494b_b5b6_288f3fcb17b5)
 
 Function for mw5be6711a_526a_4a58_80c6_d353dcabdf87 lambda(mw2f3d48e0_c9c4_4a0e_aca3_9241eb573296, mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30, mwe9501423_9fb4_494b_b5b6_288f3fcb17b5, mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30*mw2f3d48e0_c9c4_4a0e_aca3_9241eb573296/mwe9501423_9fb4_494b_b5b6_288f3fcb17b5)
 
 serum Spatial dimensions: 3.0  Compartment size: 1.0
 
 IL6
Compartment: serum
Initial concentration: 4.82830639918582E-5
 
 sgp130
Compartment: serum
Initial concentration: 3.9
 
 sR_IL6_sgp130
Compartment: serum
Initial concentration: 0.00158509246200931
 
 CRP
Compartment: serum
Initial concentration: 40.196036452179
 
 sR
Compartment: serum
Initial concentration: 1.05563779110703
 
 sR_IL6
Compartment: serum
Initial concentration: 1.99215203510923E-5
 
 Ab
Compartment: serum
Initial concentration: 1.0E-26
 
 Ab_IL6
Compartment: serum
Initial concentration: 9.8773753365085E-28
 
 Ab_sR_IL6
Compartment: serum
Initial concentration: -1.15536021610192E-26
 
 liver Spatial dimensions: 3.0  Compartment size: 1.0
 
 gp130
Compartment: liver
Initial concentration: 0.437781481555189
 
 R_IL6_gp130
Compartment: liver
Initial concentration: 1.37781774217442E-6
 
 sR_IL6
Compartment: liver
Initial concentration: 1.75027407369445E-5
 
 R
Compartment: liver
Initial concentration: 0.438768626591536
 
 IL6
Compartment: liver
Initial concentration: 5.88006568524737E-5
 
 R_IL6
Compartment: liver
Initial concentration: 8.80086553913515E-7
 
 Ractive
Compartment: liver
Initial concentration: 0.015961020646031
 
 STAT3
Compartment: liver
Initial concentration: 9.06918671945582
 
 pSTAT3
Compartment: liver
Initial concentration: 0.930813280544178
 
  CRP
Compartment: liver
Initial concentration: 28.1011462455689
 
 sR
Compartment: liver
Initial concentration: 1.51063415282403
 
 CRPExtracellular
Compartment: liver
Initial concentration: 74.1039387714523
 
 sgp130
Compartment: liver
Initial concentration: 5.58113535879753
 
 sR_IL6_sgp130
Compartment: liver
Initial concentration: 0.00209599327398083
 
 Ab_sR_IL6
Compartment: liver
Initial concentration: -1.40627697813568E-27
 
 Ab_IL6
Compartment: liver
Initial concentration: 1.08229088508198E-27
 
 Ab
Compartment: liver
Initial concentration: 1.0E-26
 
 gut Spatial dimensions: 3.0  Compartment size: 1.0
 
 sR_IL6
Compartment: gut
Initial concentration: 2.37592804897571E-5
 
 gp130
Compartment: gut
Initial concentration: 0.437466744395661
 
 R_IL6_gp130
Compartment: gut
Initial concentration: 1.794860923584E-6
 
 Ractive
Compartment: gut
Initial concentration: 0.0207923272427145
 
 STAT3
Compartment: gut
Initial concentration: 8.76987224478195
 
 pSTAT3
Compartment: gut
Initial concentration: 1.23012775521805
 
  geneProduct
Compartment: gut
Initial concentration: 36.1475993924768
 
 sR
Compartment: gut
Initial concentration: 1.51017985268264
 
 IL6
Compartment: gut
Initial concentration: 7.43306813085487E-4
 
 sgp130
Compartment: gut
Initial concentration: 5.58075296241649
 
 sR_IL6_sgp130
Compartment: gut
Initial concentration: 0.00247838965501352
 
 Ab
Compartment: gut
Initial concentration: 1.0E-26
 
 Ab_IL6
Compartment: gut
Initial concentration: 1.04407998182156E-26
 
 Ab_sR_IL6
Compartment: gut
Initial concentration: -2.42821658464018E-27
 
 peripheral Spatial dimensions: 3.0  Compartment size: 1.0
 
 Ab
Compartment: peripheral
Initial concentration: 1.0E-26
 
Global Parameters (51)
 
   kRLOn
Value: 0.384
Constant
 
 kRLOff
Value: 1.92
Constant
 
   kgp130On
Value: 20.52
Constant
 
 kgp130Off
Value: 1.026
Constant
 
   kRAct
Value: 155.0
Constant
 
 kRint
Value: 1.96
Constant
 
 kRsynth
Value: 0.0685
Constant
 
   kRintBasal
Value: 0.1561
Constant
 
   ksynthIL6
Value: 0.0011
Constant
 
 kdegIL6
Value: 34.82
Constant
 
   kdegCRP
Value: 0.36
Constant
 
 KmSTATDephos
Value: 5.34
Constant
 
   VmSTATDephos
Value: 0.62
Constant
 
 VmRDephos
Value: 0.525
Constant
 
   KmRDephos
Value: 155.3
Constant
 
 kcatSTATPhos
Value: 145.0
Constant
 
 KmSTATPhos
Value: 219.0
Constant
 
   KmProtSynth
Value: 10.0
Constant
 
 VmProtSynth
Value: 330.0
Constant
 
   kCRPSecretion
Value: 0.5
Constant
 
 ksynthCRP
Value: 0.42
Constant
 
   ksynthsR
Value: 0.1
Constant
 
 kdegsR
Value: 0.3
Constant
 
   ksynthsgp130
Value: 3.9
Constant
 
 kdegsgp130
Value: 1.0
Constant
 
   ksynthIL6Gut
Value: 0.0017
Constant
 
   kdegIL6Gut
Value: 1.0
Constant
 
   kdistTissueToSerum
Value: 0.8473
Constant
 
 kdistSerumToTissue
Value: 1.2125
Constant
 
   kRShedding
Value: 0.0054
Constant
 
   kintActiveR
Value: 0.01
Constant
 
   kIL6AbBind
Value: 1000.0
Constant
 
 kIL6AbUnbind
Value: 2.5
Constant
 
   kAbSerumToLiver
Value: 0.0208333333333333
Constant
 
   kAbLiverToSerum
Value: 0.0208333333333333
Constant
 
   kAbSerumToGut
Value: 0.0104166666666667
Constant
 
   kAbGutToSerum
Value: 0.0208333333333333
Constant
 
   VSerum
Value: 2.88
Constant
 
   VLiver
Value: 2.88
Constant
 
   VGut
Value: 1.44
Constant
 
   VPeriph
Value: 0.576
Constant
 
   QSerumLiver
Value: 0.06
Constant
 
   QSerumGut
Value: 0.03
Constant
 
   QSerumPeriph
Value: 0.001
Constant
 
   kAbSerumToPeriph
Value: 3.47222222222222E-4
Constant
 
 kAbPeriphToSerum
Value: 0.00173611111111111
Constant
 
   kdegAb
Value: 0.0018
Constant
 
 infusionTime
Value: 1.0
Constant
 
 Dose
Value: 100.0
Constant
 
 Initial for Ab
Value: 1.0E-26
Constant
 
 Initial for Dose
Value: 100.0
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000534

Curator's comment: (updated: 05 Aug 2014 17:23:59 GMT)

Figure 2c: Concentration of serum antibody with monthly (672 hours) dose regimen for three doses, 10 mg, 100 mg and 500 mg.
Simulated using a parameter scan for Dose between 10 and 500 with 2 logarithmic intervals.

Figure 2d: Concentration of antibody in serum, liver and gut compartments with monthly (672 h) dose regimen. A dose of 100 mg was used.
Simulated using a Time Course for 2688 h (16 weeks).

Additional file(s)
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