|
|
r1 |
→ [Tau03R]; |
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Tau synthesis
|
|
r2 |
[Tau03R] + [ATP] → [TauN3R] + [ADP];
{Tau03R} , {ATP}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Phosphorylation of newly synthesized tau
|
|
r3 |
[TauN3R] → [Tau03R];
{TauN3R}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
dephosphosrylation of normally phosphorylated tau
|
|
r4 |
[TauN3R] + [ATP] → [TauH3R] + [ADP];
{TauN3R} , {ATP}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Phosphorylation of normally phosphorylated tau
|
|
r5 |
[TauH3R] → [TauN3R];
{TauH3R}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Dephosphorylation of abnormal/misfolded tau
|
|
r6 |
[Tau03R] → [Tau0*3R];
{Tau03R}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Conformation change favoring MT binding
|
|
r7 |
[Tau0*3R] → [Tau03R];
{Tau0*3R}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Conformational change back to original
|
|
r8 |
[Tau0*3R] + [MT] → [Tau03RMT];
{Tau0*3R} , {MT}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Binding of newly synthesized tau to MT
|
|
r9 |
[Tau03RMT] → [Tau0*3R] + [MT];
{Tau03RMT}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Release of newly synthesized au from MT
|
|
r10 |
[TauN3R] → [TauN*3R];
{TauN3R}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Conformation chang favoring MT binding
|
|
r11 |
[TauN*3R] → [TauN3R];
{TauN*3R}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Conformational change back to original
|
|
r12 |
[TauN*3R] + [MT] → [TauN3RMT];
{TauN*3R} , {MT}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Binding of normally phosphorylated tau to MT
|
|
r13 |
[TauN3RMT] → [TauN*3R] + [MT];
{TauN3RMT}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Release of normally phosphorylated tau from MT
|
|
r14 |
[TauH3R] → [TauH*3R];
{TauH3R}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Conformational change favoring MT binding
|
|
r15 |
[TauH*3R] → [TauH3R];
{TauH*3R}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Conformational change backt to original
|
|
r16 |
[TauH*3R] + [MT] → [TauH3RMT];
{TauH*3R} , {MT}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Binding of misfolded tau to MT
|
|
r17 |
[TauH3RMT] → [TauH*3R] + [MT];
{TauH3RMT}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Release of misfolded tau from microtubules
|
|
r18 |
[Tau03R] + [20S] + [ATP] → [ADP] + [20S];
{Tau03R} , {20S} , {ATP}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Degradation of newly synthesized tau
|
|
r19 |
[TauN3R] + [20S] + [ATP] → [ADP] + [20S];
{TauN3R} , {20S} , {ATP}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Degradation of phosphorlated tau
|
|
r20 |
[TauH3R] + [20S] + [ATP] → [20S] + [ADP];
{TauH3R} , {20S} , {ATP}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Degradation of misfolded tau
|
|
r21 |
[Tau03RMT] + [ATP] → [TauN3RMT] + [ADP];
{Tau03RMT} , {ATP}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Phosphorylation of MT-bound newly synthesized tau
|
|
r22 |
[TauN3RMT] → [Tau03RMT];
{TauN3RMT}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Dephosphorylation of MT-bound normally phosphorylated tau
|
|
r23 |
[TauN3RMT] + [ATP] → [TauH3RMT] + [ADP];
{TauN3RMT} , {ATP}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Phosphorylation of MT-bound normally phosphorylated tau
|
|
r24 |
[TauH3RMT] → [TauN3RMT];
{TauH3RMT}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Dephosphorylation of MT-bound abnormal/midfolded tau
|
|
r25 |
[TauH3R] + [Hsc70] → [TauH3R-Hsc70];
{TauH3R} , {Hsc70}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Association of misfolded tau with Hsp70
|
|
r26 |
[TauH3R-Hsc70] → [TauH3R] + [Hsc70];
{TauH3R-Hsc70}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Hsc70 release
|
|
r27 |
[TauH3R-Hsc70] + [Hsp90] → [TauH3R-Hsp90] + [Hsc70];
{TauH3R-Hsc70} , {Hsp90}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Exchange of Hsc70 for Hsp90
|
|
r28 |
[TauH3R-Hsp90] → [Tau03R-Hsp90];
{TauH3R-Hsp90}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Restoration of TauH to Tau0 via Hsp90
|
|
r29 |
[Tau03R-Hsp90] → [Hsp90] + [Tau03R];
{Tau03R-Hsp90}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Release of Tau0 from Hsp90
|
|
r30 |
[TauH3R-Hsc70] + [CHIP] → [TauH3R-CHIP-Hsc70];
{TauH3R-Hsc70} , {CHIP}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Exchange of Hsc70 for CHIP
|
|
r31 |
[TauH3R-CHIP-Hsc70] → [TauH3RUb] + [Hsc70] + [CHIP];
{TauH3R-CHIP-Hsc70}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Ubiquitination of tau
|
|
r32 |
[TauH3R-CHIP-Hsc70] + [Bag2] → [TauH3R-CHIP-Hsc70-Bag2];
{TauH3R-CHIP-Hsc70} , {Bag2}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Binding of Bag-2 to the degradation complex
|
|
r33 |
[TauH3R-CHIP-Hsc70-Bag2] → [TauH3R-Hsc70] + [CHIP] + [Bag2];
{TauH3R-CHIP-Hsc70-Bag2}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Rescue for degradation by Bag2
|
|
r34 |
[TauH3RUb] + [26S] + [ATP] → [ADP] + [26S];
{TauH3RUb} , {26S} , {ATP}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Degradation of ubiquitinated tau
|
|
r35 |
→ [Tau04R]; |
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Synthesis of 4R tau
|
|
r36 |
[Tau04R] + [ATP] → [TauN4R] + [ADP];
{Tau04R} , {ATP}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Phosphorylation of newly synthesized tau
|
|
r37 |
[TauN4R] → [Tau04R];
{TauN4R}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Dephosphorylation of normally phosphorylated tau
|
|
r38 |
[TauN4R] + [ATP] → [TauH4R] + [ADP];
{TauN4R} , {ATP}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Phosphorylation of normally phosphorylated tau
|
|
r39 |
[TauH4R] → [TauN4R];
{TauH4R}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Dephosphorylation of abnormal/misfolded tau
|
|
r40 |
[Tau04R] → [Tau0*4R];
{Tau04R}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Conformation change favoring MT binding
|
|
r41 |
[Tau0*4R] → [Tau04R];
{Tau0*4R}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Conformational change back to original
|
|
r42 |
[Tau0*4R] + [MT] → [Tau04RMT];
{Tau0*4R} , {MT}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Binding of newly shynthesized tau to MT
|
|
r43 |
[Tau04RMT] → [Tau0*4R] + [MT];
{Tau04RMT}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Release of newly shyntesized tau from MT
|
|
r44 |
[TauN4R] → [TauN*4R];
{TauN4R}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Conformation change favoring MT binding
|
|
r45 |
[TauN*4R] → [TauN4R];
{TauN*4R}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Conformational change back to original
|
|
r46 |
[TauN*4R] + [MT] → [TauN4RMT];
{TauN*4R} , {MT}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Binding of normally phosphorylated tau to MT
|
|
r47 |
[TauN4RMT] → [TauN*4R] + [MT];
{TauN4RMT}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Release of normally phosphorylated tau from MT
|
|
r48 |
[TauH4R] → [TauH*4R];
{TauH4R}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Conformation change favoring MT binding
|
|
r49 |
[TauH*4R] → [TauH4R];
{TauH*4R}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Conformational change back to original
|
|
r50 |
[TauH*4R] + [MT] → [TauH4RMT];
{TauH*4R} , {MT}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Binding of misfolded tau to MT
|
|
r51 |
[TauH4RMT] → [TauH*4R] + [MT];
{TauH4RMT}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Release of misfolded tau from microtubules
|
|
r52 |
[Tau04R] + [20S] + [ATP] → [ADP] + [20S];
{Tau04R} , {20S} , {ATP}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Degradation of newly shynthesized tau
|
|
r53 |
[TauN4R] + [20S] + [ATP] → [ADP] + [20S];
{TauN4R} , {20S} , {ATP}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Degradation of phosphorylated tau
|
|
r54 |
[TauH4R] + [20S] + [ATP] → [ADP] + [20S];
{TauH4R} , {20S} , {ATP}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Degradation of misfolded tau
|
|
r55 |
[Tau04RMT] + [ATP] → [TauN4RMT] + [ADP];
{Tau04RMT} , {ATP}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Phosphorylation of MT-bound newly synthesized tau
|
|
r56 |
[TauN4RMT] → [Tau04RMT];
{TauN4RMT}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Dephosphorylation of MT-bound normally phosphorylated tau
|
|
r57 |
[TauN4RMT] + [ATP] → [TauH4RMT] + [ADP];
{TauN4RMT} , {ATP}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Phosphorylation of MT-bound normally phosphorylated tau
|
|
r58 |
[TauH4RMT] → [TauN4RMT];
{TauH4RMT}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Dephosphorylation of MT-bound abnormal/misfolded tau
|
|
r59 |
[TauH4R] + [Hsc70] → [TauH4R-Hsc70];
{TauH4R} , {Hsc70}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Association of misfolded tau with Hsp70
|
|
r60 |
[TauH4R-Hsc70] → [TauH4R] + [Hsc70];
{TauH4R-Hsc70}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Hsc70 release
|
|
r61 |
[TauH4R-Hsc70] + [Hsp90] → [TauH4R-Hsp90] + [Hsc70];
{TauH4R-Hsc70} , {Hsp90}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Exchange of Hsc70 for Hsp90
|
|
r62 |
[TauH4R-Hsp90] → [Tau04R-Hsp90];
{TauH4R-Hsp90}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Restoration of TauH to Tau0 via Hsp90
|
|
r63 |
[Tau04R-Hsp90] → [Hsp90] + [Tau04R];
{Tau04R-Hsp90}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Release of Tau0 from Hsp90
|
|
r64 |
[TauH4R-Hsc70] + [CHIP] → [TauH4R-CHIP-Hsc70];
{TauH4R-Hsc70} , {CHIP}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Exchange of Hsc70 for CHIP
|
|
r65 |
[TauH4R-CHIP-Hsc70] → [TauH4RUb] + [Hsc70] + [CHIP];
{TauH4R-CHIP-Hsc70}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Ubiquitination of tau
|
|
r66 |
[TauH4R-CHIP-Hsc70] + [Bag2] → [TauH4R-CHIP-Hsc70-Bag2];
{TauH4R-CHIP-Hsc70} , {Bag2}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Binding of Bag-2 to the degradation complex
|
|
r67 |
[TauH4R-CHIP-Hsc70-Bag2] → [TauH4R-Hsc70] + [CHIP] + [Bag2];
{TauH4R-CHIP-Hsc70-Bag2}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Rescue from degradation by Bag2
|
|
r68 |
[TauH4RUb] + [26S] + [ATP] → [ADP] + [26S];
{TauH4RUb} , {26S} , {ATP}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Degradation of ubiquitinated tau
|
|
r69 |
[ADP] → [ATP];
{ADP}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Generation of ATP
|
|
r70 |
[ATP] → [ADP];
{ATP}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Use of ATP by other processes
|
|
r71 |
2.0 × [TauH3RUb] → [Nucleus3];
{TauH3RUb}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Nucleation of Tau3
|
|
r72 |
[Nucleus3] → 2.0 × [TauH3RUb];
{Nucleus3}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Dissociation of Tau3 Nucleus
|
|
r73 |
2.0 × [TauH4RUb] → [Nucleus4];
{TauH4RUb}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Nucleation of Tau4
|
|
r74 |
[Nucleus4] → 2.0 × [TauH4RUb];
{Nucleus4}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Dissociation of Tau4 Nucleus
|
|
r75 |
[Nucleus3] + [TauH3RUb] → [Agg33];
{Nucleus3} , {TauH3RUb}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Formation of Tau3, length 3
|
|
r76 |
[Agg33] → [Nucleus3] + [TauH3RUb];
{Agg33}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Dissociation
|
|
r77 |
[TauH3RUb] + [Agg33] → [Ap];
{TauH3RUb} , {Agg33}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Formation of Tau3, 1 > 3 from Tau3 aggregate of length 3
|
|
r78 |
[TauH3RUb] + [Ap] → [Ap];
{TauH3RUb} , {Ap}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Formation of Agg of 1 > 3 from aggregaties of 1 > 3
|
|
r79 |
[Ap] → [TauH3RUb] + [Ap];
{Ap}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Dissociation of aggregates 1 > 3
|
|
r80 |
[Nucleus4] + [TauH4RUb] → [Agg43];
{Nucleus4} , {TauH4RUb}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Formation of Tau4, length 3
|
|
r81 |
[Agg43] → [Nucleus4] + [TauH4RUb];
{Agg43}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Dissociation
|
|
r82 |
[TauH4RUb] + [Agg43] → [Bp];
{TauH4RUb} , {Agg43}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Formation of Tau4, 1 > 3 from Tau3 aggreate of length 3
|
|
r83 |
[TauH4RUb] + [Bp] → [Bp];
{TauH4RUb} , {Bp}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Formation of Agg of 1 > 3 from aggregates of 1 >3
|
|
r84 |
[Bp] → [TauH4RUb] + [Bp];
{Bp}
|
Math: |
(Details: ) |
Annotations: |
|
Notes:
|
Dissociation of aggregates 1 > 3
|
|
|
|
Rate Rule (name: _20S) |
d [
20S] / d t= 0 |
Math: |
(Details: ) |
|
|
Rate Rule (name: _26S) |
d [
26S] / d t= 0 |
Math: |
(Details: ) |
|
|
Rate Rule (name: Ap) |
d [
Ap] / d t= r77 |
Math: |
(Details: ) |
|
|
Rate Rule (name: Bp) |
d [
Bp] / d t= r82 |
Math: |
(Details: ) |
|
|
|
|
Constant flux (irreversible) |
lambda(v, v) |
Math: |
 |
|
|
Henri-Michaelis-Menten (irreversible) |
lambda(substrate, Km, V, V*substrate/(Km+substrate)) |
Math: |
 |
|
|
Mass Action* |
lambda(k1, x1, x2, k1*x1*x2) |
Math: |
 |
|
|
Michaelis-Menten* |
lambda(k1, x1, x2, k2, k1*x1*x2/(k2+x1)) |
Math: |
 |
|
|
Mass Action** |
lambda(K1, x1, x2, x3, K1*x1*x2*x3) |
Math: |
 |
|
|
Nucleation |
lambda(k1, x1, k1*x1^2) |
Math: |
 |
|
|