Ehrenstein2000 - Positive-Feedback model for the loss of acetylcholine in Alzheimer's disease

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Short description
Ehrenstein2000 - Positive-Feedback model for the loss of acetylcholine in Alzheimer's disease
Curated model derived from

BIOMD0000000553

This model is described in the article:

Ehrenstein G, Galdzicki Z, Lange GD.
Ann. N. Y. Acad. Sci. 2000; 899: 283-291

Abstract:

We describe a two-component positive-feedback system that could account for the large reduction of acetylcholine that is characteristic of patients with Alzheimer's disease (AD). One component is beta-amyloid-induced apoptosis of cholinergic cells, leading to a decrease in acetylcholine. The other component is an increase in the concentration of beta-amyloid in response to a decrease in acetylcholine. We describe each mechanism with a differential equation, and then solve the two equations numerically. The solution provides a description of the time course of the reduction of acetylcholine in AD patients that is consistent with epidemiological data. This model may also provide an explanation for the significant, but lesser, decrease of other neurotransmitters that is characteristic of AD.

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Format
SBML (L2V4)
Related Publication
  • A positive-feedback model for the loss of acetylcholine in Alzheimer's disease.
  • Ehrenstein G, Galdzicki Z, Lange GD
  • Annals of the New York Academy of Sciences , 0/ 2000 , Volume 899 , pages: 283-291
  • Biophysics Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA. gerry@helix.nih.gov
  • We describe a two-component positive-feedback system that could account for the large reduction of acetylcholine that is characteristic of patients with Alzheimer's disease (AD). One component is beta-amyloid-induced apoptosis of cholinergic cells, leading to a decrease in acetylcholine. The other component is an increase in the concentration of beta-amyloid in response to a decrease in acetylcholine. We describe each mechanism with a differential equation, and then solve the two equations numerically. The solution provides a description of the time course of the reduction of acetylcholine in AD patients that is consistent with epidemiological data. This model may also provide an explanation for the significant, but lesser, decrease of other neurotransmitters that is characteristic of AD.
Contributors
Audald Lloret i Villas

Metadata information

is
BioModels Database MODEL1410200001
BioModels Database BIOMD0000000552
isDerivedFrom
BioModels Database BIOMD0000000553
PubMed 9284295
isDescribedBy
PubMed 10863547
hasTaxon
Taxonomy Homo sapiens
isVersionOf
hasVersion
Human Disease Ontology Alzheimer's disease
Curation status
Curated
  • Model originally submitted by : Audald Lloret i Villas
  • Submitted: 20-Oct-2014 13:31:24
  • Last Modified: 12-Dec-2014 15:03:14
Revisions
  • Version: 2 public model Download this version
    • Submitted on: 12-Dec-2014 15:03:14
    • Submitted by: Audald Lloret i Villas
    • With comment: Current version of Ehrenstein2000 - Positive-Feedback model for the loss of acetylcholine in Alzheimer's disease
  • Version: 1 public model Download this version
    • Submitted on: 20-Oct-2014 13:31:24
    • Submitted by: Audald Lloret i Villas
    • With comment: Original import of Ehrenstein2000 - Positive-Feedback model for the loss of acetylcholine in Alzheimer's disease
Curator's comment:
(added: 20 Oct 2014, 15:06:26, updated: 20 Oct 2014, 15:06:26)
Figure 1 has been reproduced here. Time course of the decline in acetylcholine is plotted ranging different values for k2 parameter. The simulation was done using Copasi v4.12 (Build 81) and the plots were generated using Gnuplot. The Copasi file of the model with simulation settings can be downloaded from the below link.