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Auer2010 - Correlation between lag time and aggregation rate in protein aggregation

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Short description
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SBML (L2V4)
Related Publication
  • Insight into the correlation between lag time and aggregation rate in the kinetics of protein aggregation.
  • Auer S, Kashchiev D
  • Proteins , 8/ 2010 , Volume 78 , pages: 2412-2416
  • Centre for Molecular Nanoscience, University of Leeds, Leeds, LS2 9JT, United Kingdom. s.auer@leeds.ac.uk
  • Under favorable conditions, many proteins can assemble into macroscopically large aggregates such as the amyloid fibrils that are associated with Alzheimer's, Parkinson's, and other neurological and systemic diseases. The overall process of protein aggregation is characterized by initial lag time during which no detectable aggregation occurs in the solution and by maximal aggregation rate at which the dissolved protein converts into aggregates. In this study, the correlation between the lag time and the maximal rate of protein aggregation is analyzed. It is found that the product of these two quantities depends on a single numerical parameter, the kinetic index of the curve quantifying the time evolution of the fraction of protein aggregated. As this index depends relatively little on the conditions and/or system studied, our finding provides insight into why for many experiments the values of the product of the lag time and the maximal aggregation rate are often equal or quite close to each other. It is shown how the kinetic index is related to a basic kinetic parameter of a recently proposed theory of protein aggregation.
Contributors
Audald Lloret i Villas, administrator

Metadata information

Curation status
Curated
Name Description Size Actions

Model files

BIOMD0000000555.xml.origin SBML L2V4 representation of Auer2010 - Correlation between lag time and aggregation rate in protein aggregation 9.66 KB Preview | Download

Additional files

Auer2010.cps Copasi file of the model 30.20 KB Preview | Download

  • Model originally submitted by : Audald Lloret i Villas
  • Submitted: Nov 10, 2014 1:33:38 PM
  • Last Modified: Dec 21, 2018 5:39:19 PM
Revisions
  • Version: 3 public model Download this version
    • Submitted on: Dec 21, 2018 5:39:19 PM
    • Submitted by: administrator
    • With comment: Include the additional files provided by the submitter in the original submission: Auer2010.cps
  • Version: 2 public model Download this version
    • Submitted on: Apr 8, 2016 6:42:51 PM
    • Submitted by: Audald Lloret i Villas
    • With comment: Current version of Auer2010 - Correlation between lag time and aggregation rate in protein aggregation
  • Version: 1 public model Download this version
    • Submitted on: Nov 10, 2014 1:33:38 PM
    • Submitted by: Audald Lloret i Villas
    • With comment: Original import of Auer2010 - Correlation between lag time and aggregation rate in protein aggregation
Curator's comment:
(added: 10 Nov 2014, 15:15:48, updated: 10 Nov 2014, 15:15:48)
Figure 1 (upper panel) and Figure 2 (lower panel) have been reproduced here. Figure 1. Analysis of kinetic amyloid fibrils data for 80 hours protein aggregation. Figure 2. Dependence of the parameter a on the kinetic index n in overall aggregation. The simulation was done using Copasi v4.12 (Build 81) and the plots were generated using Gnuplot. The models with simulation settings can be downloaded from the below link: