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Mufudza2012 - Estrogen effect on the dynamics of breast cancer

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Short description
Format
SBML (L2V4)
Related Publication
  • Assessing the effects of estrogen on the dynamics of breast cancer
  • Mufudza C, Sorofa W, Chiyaka ET
  • Computational and mathematical methods in medicine , 12/ 2012 , Volume 2012 , pages: 473572
  • Department of Applied Mathematics, National University of Science and Technology, Ascot, Bulawayo, Zimbabwe. chipmuf@gmail.com
  • Worldwide, breast cancer has become the second most common cancer in women. The disease has currently been named the most deadly cancer in women but little is known on what causes the disease. We present the effects of estrogen as a risk factor on the dynamics of breast cancer. We develop a deterministic mathematical model showing general dynamics of breast cancer with immune response. This is a four-population model that includes tumor cells, host cells, immune cells, and estrogen. The effects of estrogen are then incorporated in the model. The results show that the presence of extra estrogen increases the risk of developing breast cancer.
Contributors
Vijayalakshmi Chelliah, administrator

Metadata information

Curation status
Curated
  • Model originally submitted by : Vijayalakshmi Chelliah
  • Submitted: Apr 19, 2013 9:59:20 AM
  • Last Modified: Oct 6, 2017 10:41:19 AM
Revisions
  • Version: 3 public model Download this version
    • Submitted on: Oct 6, 2017 10:41:19 AM
    • Submitted by: administrator
    • With comment: Update the model file
  • Version: 2 public model Download this version
    • Submitted on: Apr 19, 2013 12:01:25 PM
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Current version of Mufudza2012 - Estrogen effect on the dynamics of breast cancer
  • Version: 1 public model Download this version
    • Submitted on: Apr 19, 2013 9:59:20 AM
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Original import of Mufudza2012 - Estrogen effect on the dynamics of breast cancer
Curator's comment:
(added: 24 Aug 2017, 17:06:55, updated: 24 Aug 2017, 17:06:55)
Figure 3b of the reference publication has been reproduced. The model as such reproduces the plots corresponding to the excess estrogen condition. The simulations where performed and the plot was generated using Copasi 4.19 (Build 140).