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Non-homologous end-joining - Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)


Model information
Identifier: BMID000000002902
Format: SBML L3 V1 (Layout, Qualitative Models)
Project: path2models
Categories: non-metabolic
Submission: 17 May 2012 15:23:56 UTC
Last modified: 07 Dec 2012 23:53:21 UTC
Published: 20 May 2012 00:49:21 UTC
isDescribedBy double-strand break repair via nonhomologous end joining Gene Ontology
occursIn Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) Taxonomy
isDerivedFrom Non-homologous end-joining KEGG Pathway
Model of “Non-homologous end-joining” in “Laccaria bicolor S238N-H82”
Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.

Graphical representation of 'Non-homologous end-joining (Laccaria bicolor S238N-H82)'
(PNG image hosted by the Kyoto Encyclopedia of Genes and Genomes, KEGG).
This model has been automatically generated by KEGGtranslator V2.3.0 (KEGGtranslator: visualizing and converting the KEGG PATHWAY database to various formats. Wrzodek C, Dräger A, Zell A. Bioinformatics . 2011, 27 :2314-2315) using information coming from the KEGG PATHWAY Database ( original pathway ).
This model has been produced by the path2models project, it is currently hosted on BioModels Database and identified by: BMID000000002902 .
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.