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Ubiquitin mediated proteolysis - Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)


Model information
Identifier: BMID000000002909
Format: SBML L3 V1 (Layout, Qualitative Models)
Project: path2models
Categories: non-metabolic
Submission: 17 May 2012 15:24:00 UTC
Last modified: 07 Dec 2012 23:53:26 UTC
Published: 20 May 2012 00:49:21 UTC
isDescribedBy protein ubiquitination Gene Ontology
occursIn Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) Taxonomy
isDerivedFrom Ubiquitin mediated proteolysis KEGG Pathway
Model of “Ubiquitin mediated proteolysis” in “Laccaria bicolor S238N-H82”
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.

Graphical representation of 'Ubiquitin mediated proteolysis (Laccaria bicolor S238N-H82)'
(PNG image hosted by the Kyoto Encyclopedia of Genes and Genomes, KEGG).
This model has been automatically generated by KEGGtranslator V2.3.0 (KEGGtranslator: visualizing and converting the KEGG PATHWAY database to various formats. Wrzodek C, Dräger A, Zell A. Bioinformatics . 2011, 27 :2314-2315) using information coming from the KEGG PATHWAY Database ( original pathway ).
This model has been produced by the path2models project, it is currently hosted on BioModels Database and identified by: BMID000000002909 .
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