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Natural killer cell mediated cytotoxicity - Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)

 

Model information
Identifier: BMID000000002912
Format: SBML L3 V1 (Layout, Qualitative Models)
Project: path2models
Categories: non-metabolic
Submission: 17 May 2012 15:24:00 UTC
Last modified: 07 Dec 2012 23:53:28 UTC
Published: 20 May 2012 00:49:21 UTC
Annotations
isDescribedBy natural killer cell mediated cytotoxicity Gene Ontology
occursIn Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) Taxonomy
isDerivedFrom Natural killer cell mediated cytotoxicity KEGG Pathway
Notes
Model of “Natural killer cell mediated cytotoxicity” in “Laccaria bicolor S238N-H82”
Natural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stress, such as infection with viruses, bacteria, or parasites or malignant transformation. Although NK cells do not express classical antigen receptors of the immunoglobulin gene family, such as the antibodies produced by B cells or the T cell receptor expressed by T cells, they are equipped with various receptors whose engagement allows them to discriminate between target and nontarget cells. Activating receptors bind ligands on the target cell surface and trigger NK cell activation and target cell lysis. However Inhibitory receptors recognize MHC class I molecules (HLA) and inhibit killing by NK cells by overruling the actions of the activating receptors. This inhibitory signal is lost when the target cells do not express MHC class I and perhaps also in cells infected with virus, which might inhibit MHC class I exprssion or alter its conformation. The mechanism of NK cell killing is the same as that used by the cytotoxic T cells generated in an adaptive immune response; cytotoxic granules are released onto the surface of the bound target cell, and the effector proteins they contain penetrate the cell membrane and induce programmed cell death.

Graphical representation of 'Natural killer cell mediated cytotoxicity (Laccaria bicolor S238N-H82)'
(PNG image hosted by the Kyoto Encyclopedia of Genes and Genomes, KEGG).
This model has been automatically generated by KEGGtranslator V2.3.0 (KEGGtranslator: visualizing and converting the KEGG PATHWAY database to various formats. Wrzodek C, Dräger A, Zell A. Bioinformatics . 2011, 27 :2314-2315) using information coming from the KEGG PATHWAY Database ( original pathway ).
This model has been produced by the path2models project, it is currently hosted on BioModels Database and identified by: BMID000000002912 .
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
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