BioModels Database logo

BioModels Database


Phototransduction - fly - Drosophila ananassae


Model information
Identifier: BMID000000008294
Format: SBML L3 V1 (Layout, Qualitative Models)
Project: path2models
Categories: non-metabolic
Submission: 17 May 2012 16:16:22 UTC
Last modified: 07 Dec 2012 22:23:47 UTC
Published: 20 May 2012 00:49:21 UTC
occursIn Drosophila ananassae Taxonomy
isDerivedFrom Phototransduction - fly KEGG Pathway
Model of “Phototransduction - fly” in “Drosophila ananassae”
Phototransduction is the process that converts the signal of light (photons) into a change of membrane potential in photoreceptor cells. Drosophila visual signaling is initiated with the activation of rhodopsin by light. Rhodopsin is composed of a protein, opsin, covalently linked to a chromophore, 3-hydroxy-11-cis-retinal. Upon absorption of a light photon the chromophore is isomerized from the 11-cis to the all-trans configuration which induces a structural change that activates the opsin. This photoconversion activates heterotrimeric Gq protein via GTP-GDP exchange, releasing the G(alpha)q subunit. G(alpha)q activates PLC, generating InsP3 and DAG from PIP2. DAG may further release polyunsaturated fatty acids (PUFAs) via action of DAG lipase. This reaction leads to the opening of cation-selective channels (trp and trpl genes) and causes the depolarization of the photoreceptor cells. The transduction proteins rhodopsin, G(alpha)q, PLC, PKC, TRP, and TRPL are coordinated by a polymer of INAD scaffold proteins.

Graphical representation of 'Phototransduction - fly (Drosophila ananassae)'
(PNG image hosted by the Kyoto Encyclopedia of Genes and Genomes, KEGG).
This model has been automatically generated by KEGGtranslator V2.3.0 (KEGGtranslator: visualizing and converting the KEGG PATHWAY database to various formats. Wrzodek C, Dräger A, Zell A. Bioinformatics . 2011, 27 :2314-2315) using information coming from the KEGG PATHWAY Database ( original pathway ).
This model has been produced by the path2models project, it is currently hosted on BioModels Database and identified by: BMID000000008294 .
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.