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Homologous recombination - Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)


Model information
Identifier: BMID000000009074
Format: SBML L3 V1 (Layout, Qualitative Models)
Project: path2models
Categories: non-metabolic
Submission: 17 May 2012 16:24:19 UTC
Last modified: 08 Dec 2012 00:35:31 UTC
Published: 20 May 2012 00:49:21 UTC
isDescribedBy double-strand break repair via homologous recombination Gene Ontology
occursIn Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c) Taxonomy
isDerivedFrom Homologous recombination KEGG Pathway
Model of “Homologous recombination” in “Candidatus Methanosphaerula palustris E1-9c”
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.

Graphical representation of 'Homologous recombination (Candidatus Methanosphaerula palustris E1-9c)'
(PNG image hosted by the Kyoto Encyclopedia of Genes and Genomes, KEGG).
This model has been automatically generated by KEGGtranslator V2.3.0 (KEGGtranslator: visualizing and converting the KEGG PATHWAY database to various formats. Wrzodek C, Dräger A, Zell A. Bioinformatics . 2011, 27 :2314-2315) using information coming from the KEGG PATHWAY Database ( original pathway ).
This model has been produced by the path2models project, it is currently hosted on BioModels Database and identified by: BMID000000009074 .
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.