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Protein processing in endoplasmic reticulum - Pongo abelii

 

Model information
Identifier: BMID000000016422
Format: SBML L3 V1 (Layout, Qualitative Models)
Project: path2models
Categories: non-metabolic
Submission: 17 May 2012 17:46:05 UTC
Last modified: 08 Dec 2012 01:17:44 UTC
Published: 20 May 2012 00:49:21 UTC
Annotations
isDescribedBy response to endoplasmic reticulum stress Gene Ontology
isDescribedBy ER-associated protein catabolic process Gene Ontology
occursIn Pongo abelii Taxonomy
isDerivedFrom Protein processing in endoplasmic reticulum KEGG Pathway
Notes
Model of “Protein processing in endoplasmic reticulum” in “Pongo abelii (Sumatran orangutan)”
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.

Graphical representation of 'Protein processing in endoplasmic reticulum (Pongo abelii (Sumatran orangutan))'
(PNG image hosted by the Kyoto Encyclopedia of Genes and Genomes, KEGG).
This model has been automatically generated by KEGGtranslator V2.3.0 (KEGGtranslator: visualizing and converting the KEGG PATHWAY database to various formats. Wrzodek C, Dräger A, Zell A. Bioinformatics . 2011, 27 :2314-2315) using information coming from the KEGG PATHWAY Database ( original pathway ).
This model has been produced by the path2models project, it is currently hosted on BioModels Database and identified by: BMID000000016422 .
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
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