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Osteoclast differentiation - Pongo abelii

 

Model information
Identifier: BMID000000016438
Format: SBML L3 V1 (Layout, Qualitative Models)
Project: path2models
Categories: non-metabolic
Submission: 17 May 2012 17:46:14 UTC
Last modified: 08 Dec 2012 01:17:53 UTC
Published: 20 May 2012 00:49:21 UTC
Annotations
isDescribedBy osteoclast differentiation Gene Ontology
occursIn Pongo abelii Taxonomy
isDerivedFrom Osteoclast differentiation KEGG Pathway
Notes
Model of “Osteoclast differentiation” in “Pongo abelii (Sumatran orangutan)”
The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways activated by RANK and immune receptors, whose ligands are expressed on the surface of osteoblasts. Signaling from RANK changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast.

Graphical representation of 'Osteoclast differentiation (Pongo abelii (Sumatran orangutan))'
(PNG image hosted by the Kyoto Encyclopedia of Genes and Genomes, KEGG).
This model has been automatically generated by KEGGtranslator V2.3.0 (KEGGtranslator: visualizing and converting the KEGG PATHWAY database to various formats. Wrzodek C, Dräger A, Zell A. Bioinformatics . 2011, 27 :2314-2315) using information coming from the KEGG PATHWAY Database ( original pathway ).
This model has been produced by the path2models project, it is currently hosted on BioModels Database and identified by: BMID000000016438 .
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
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