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Prostate cancer - Pongo abelii

 

Model information
Identifier: BMID000000016501
Format: SBML L3 V1 (Layout, Qualitative Models)
Project: path2models
Categories: non-metabolic
Submission: 17 May 2012 17:46:52 UTC
Last modified: 08 Dec 2012 01:18:30 UTC
Published: 20 May 2012 00:49:21 UTC
Annotations
occursIn Pongo abelii Taxonomy
isDerivedFrom Prostate cancer KEGG Pathway
Notes
Model of “Prostate cancer” in “Pongo abelii (Sumatran orangutan)”
Prostate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of key molecular alterations in prostate-cancer cells implicates carcinogen defenses (GSTP1), growth-factor-signaling pathways (NKX3.1, PTEN, and p27), and androgens (AR) as critical determinants of the phenotype of prostate-cancer cells. Glutathione S-transferases (GSTP1) are detoxifying enzymes. Cells of prostatic intraepithelial neoplasia, devoid of GSTP1, undergo genomic damage mediated by carcinogens. NKX3.1, PTEN, and p27 regulate the growth and survival of prostate cells in the normal prostate. Inadequate levels of PTEN and NKX3.1 lead to a reduction in p27 levels and to increased proliferation and decreased apoptosis. Androgen receptor (AR) is a transcription factor that is normally activated by its androgen ligand. During androgen withdrawal therapy, the AR signal transduction pathway also could be activated by amplification of the AR gene, by AR gene mutations, or by altered activity of AR coactivators. Through these mechanisms, tumor cells lead to the emergence of androgen-independent prostate cancer.

Graphical representation of 'Prostate cancer (Pongo abelii (Sumatran orangutan))'
(PNG image hosted by the Kyoto Encyclopedia of Genes and Genomes, KEGG).
This model has been automatically generated by KEGGtranslator V2.3.0 (KEGGtranslator: visualizing and converting the KEGG PATHWAY database to various formats. Wrzodek C, Dräger A, Zell A. Bioinformatics . 2011, 27 :2314-2315) using information coming from the KEGG PATHWAY Database ( original pathway ).
This model has been produced by the path2models project, it is currently hosted on BioModels Database and identified by: BMID000000016501 .
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
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