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Bacterial invasion of epithelial cells - Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)


Model information
Identifier: BMID000000025198
Format: SBML L3 V1 (Layout, Qualitative Models)
Project: path2models
Categories: non-metabolic
Submission: 17 May 2012 19:21:01 UTC
Last modified: 08 Dec 2012 02:25:20 UTC
Published: 20 May 2012 00:49:21 UTC
occursIn Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) Taxonomy
isDerivedFrom Bacterial invasion of epithelial cells KEGG Pathway
Model of “Bacterial invasion of epithelial cells” in “Salmonella enterica subsp. enterica serovar Typhimurium LT2 (Salmonella typhimurium LT2)”
Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signalling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton.

This model has been automatically generated by KEGGtranslator V2.3.0 (KEGGtranslator: visualizing and converting the KEGG PATHWAY database to various formats. Wrzodek C, Dräger A, Zell A. Bioinformatics . 2011, 27 :2314-2315) using information coming from the KEGG PATHWAY Database ( original pathway ).
This model has been produced by the path2models project, it is currently hosted on BioModels Database and identified by: BMID000000025198 .
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.