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Terpenoid backbone biosynthesis - Anaerocellum thermophilum (strain DSM 6725 / Z-1320)

 

Model information
Identifier: BMID000000085974
Format: SBML L3 V1 (Layout)
Project: path2models
Categories: metabolic
Submission: 18 May 2012 12:00:00 UTC
Last modified: 09 Dec 2012 16:30:11 UTC
Published: 20 May 2012 00:49:21 UTC
Annotations
isDescribedBy prenol biosynthetic process Gene Ontology
isDescribedBy isopentenyl diphosphate biosynthetic process Gene Ontology
occursIn Anaerocellum thermophilum (strain DSM 6725 / Z-1320) Taxonomy
isDerivedFrom Terpenoid backbone biosynthesis KEGG Pathway
Notes
Model of “Terpenoid backbone biosynthesis” in “Caldicellulosiruptor bescii DSM 6725”
Terpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway [MD:M00095] and the non-mevalonate pathway or the MEP/DOXP pathway [MD:M00096], for the terpenoid building blocks: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). The action of prenyltransferases then generates higher-order building blocks: geranyl diphosphate (GPP), farsenyl diphosphate (FPP), and geranylgeranyl diphosphate (GGPP), which are the precursors of monoterpenoids (C10), sesquiterpenoids (C15), and diterpenoids (C20), respectively. Condensation of these building blocks gives rise to the precursors of sterols (C30) and carotenoids (C40). The MEP/DOXP pathway is absent in higher animals and fungi, but in green plants the MEP/DOXP and mevalonate pathways co-exist in separate cellular compartments. The MEP/DOXP pathway, operating in the plastids, is responsible for the formation of essential oil monoterpenes and linalyl acetate, some sesquiterpenes, diterpenes, and carotenoids and phytol. The mevalonate pathway, operating in the cytosol, gives rise to triterpenes, sterols, and most sesquiterpenes.

Graphical representation of 'Terpenoid backbone biosynthesis (Caldicellulosiruptor bescii DSM 6725)'
(PNG image hosted by the Kyoto Encyclopedia of Genes and Genomes, KEGG).
This model has been automatically generated by KEGGtranslator V2.2.0 (KEGGtranslator: visualizing and converting the KEGG PATHWAY database to various formats. Wrzodek C, Dräger A, Zell A. Bioinformatics . 2011, 27 :2314-2315) using information coming from the KEGG PATHWAY Database ( original pathway ).
The missing kinetic equations were added by SBMLsqueezer .
This model has been produced by the path2models project, it is currently hosted on BioModels Database and identified by: BMID000000085974 .
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
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