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Streptomycin biosynthesis - Mycoplasma hyopneumoniae (strain 7448)


Model information
Identifier: BMID000000110716
Format: SBML L3 V1 (Layout)
Project: path2models
Categories: metabolic
Submission: 18 May 2012 18:18:50 UTC
Last modified: 10 Dec 2012 03:27:35 UTC
Published: 20 May 2012 00:49:21 UTC
isDescribedBy streptomycin biosynthetic process Gene Ontology
occursIn Mycoplasma hyopneumoniae (strain 7448) Taxonomy
isDerivedFrom Streptomycin biosynthesis KEGG Pathway
Model of “Streptomycin biosynthesis” in “Mycoplasma hyopneumoniae 7448”
Streptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamine moieties, which are formed by independent biosynthetic pathways. All of the moieties are derived from D-glucose. The streptidine moiety is synthesized via myo-inositol, which is then oxidized at C-1 and transaminated to give scyllo-inosamine. After phosphorylation, the compound is transamidinated by arginine. The same procedure is repeated at the C-3 position. The streptose moiety is made from D-glucose via a dTDP-glucose pathway. The exact biosynthetic route for the N-methyl-L-glucosamine moiety is unknown, though the biosynthetic gene cluster have been proposed.

Graphical representation of 'Streptomycin biosynthesis (Mycoplasma hyopneumoniae 7448)'
(PNG image hosted by the Kyoto Encyclopedia of Genes and Genomes, KEGG).
This model has been automatically generated by KEGGtranslator V2.2.0 (KEGGtranslator: visualizing and converting the KEGG PATHWAY database to various formats. Wrzodek C, Dräger A, Zell A. Bioinformatics . 2011, 27 :2314-2315) using information coming from the KEGG PATHWAY Database ( original pathway ).
The missing kinetic equations were added by SBMLsqueezer .
This model has been produced by the path2models project, it is currently hosted on BioModels Database and identified by: BMID000000110716 .
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.