Noble1984_SinoAtrialNode

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Short description

This a model from the article:
A model of sino-atrial node electrical activity based on a modification of the DiFrancesco-Noble (1984) equations.
Noble D, Noble SJ. Proc R Soc Lond B Biol Sci. 1984 Sep 22;222(1228):295-304. 6149553 ,
Abstract:
DiFrancesco & Noble's (1984) equations (Phil. Trans. R. Soc. Lond. B (in the press.] have been modified to apply to the mammalian sino-atrial node. The modifications are based on recent experimental work. The modified equations successfully reproduce action potential and pacemaker activity in the node. Slightly different versions have been developed for peripheral regions that show a maximum diastolic potential near --75 mV and for central regions that do not hyperpolarize beyond --60 to --65 mV. Variations in extracellular potassium influence the frequency of pacemaker activity in the s.a. node model very much less than they do in the Purkinje fibre model. This corresponds well to the experimental observation that the node is less sensitive to external [K] than are Purkinje fibres. Activation of the Na-K exchange pump in the model by increasing intracellular sodium can suppress pacemaker activity. This phenomenon may contribute to the mechanism of overdrive suppression.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Noble D, Noble SJ. (1984) - version04
The original CellML model was created by:
Noble, Penny, J
penny.noble@dpag.ox.ac.uk
Oxford University
Department of Physiology, Anatomy & Genetics

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Format
SBML (L2V3)
Related Publication
  • A model of sino-atrial node electrical activity based on a modification of the DiFrancesco-Noble (1984) equations.
  • Noble D, Noble SJ.
  • Proc. R. Soc. Lond., B, Biol. Sci. 1984 Sep; 222(1228): 295-304 , 9/ 1984 , Volume 222 , Issue 1228 , pages: 295-304
  • DiFrancesco & Noble's (1984) equations (Phil. Trans. R. Soc. Lond. B (in the press.] have been modified to apply to the mammalian sino-atrial node. The modifications are based on recent experimental work. The modified equations successfully reproduce action potential and pacemaker activity in the node. Slightly different versions have been developed for peripheral regions that show a maximum diastolic potential near --75 mV and for central regions that do not hyperpolarize beyond --60 to --65 mV. Variations in extracellular potassium influence the frequency of pacemaker activity in the s.a. node model very much less than they do in the Purkinje fibre model. This corresponds well to the experimental observation that the node is less sensitive to external [K] than are Purkinje fibres. Activation of the Na-K exchange pump in the model by increasing intracellular sodium can suppress pacemaker activity. This phenomenon may contribute to the mechanism of overdrive suppression.
Contributors
Vijayalakshmi Chelliah

Metadata information

is
BioModels Database MODEL0406151557
isDescribedBy
PubMed 6149553
hasTaxon
Taxonomy Homo sapiens
isVersionOf
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
occursIn
Brenda Tissue Ontology sinus node
Curation status
Non-curated
Original model(s)
http://www.cellml.org/models/noble_noble_1984_version04
  • Model originally submitted by : Vijayalakshmi Chelliah
  • Submitted: Apr 22, 2009 6:53:49 PM
  • Last Modified: Apr 22, 2009 6:53:49 PM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Apr 22, 2009 6:53:49 PM
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Current version of Noble1984_SinoAtrialNode
  • Version: 1 public model Download this version
    • Submitted on: Apr 22, 2009 6:53:49 PM
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Original import of Noble1984_SinoAtrialNode