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MODEL0406151557 - Noble1984_SinoAtrialNode


The following model is part of the non-curated branch of BioModels Database. While the syntax of the model has been verified, its semantics remains unchecked. Any annotation present in the models is not a product of BioModels' annotators. We are doing our best to incorporate this model into the curated branch as soon as possible. In the meantime, we display only limited metadata here. For further information about the model, please download the SBML file.

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Reference Publication
Publication ID: 6149553
Noble D, Noble SJ.
A model of sino-atrial node electrical activity based on a modification of the DiFrancesco-Noble (1984) equations.
Proc. R. Soc. Lond., B, Biol. Sci. 1984 Sep; 222(1228): 295-304
Original Model: CellML logo
Submitter: Vijayalakshmi Chelliah
Submission Date: 22 Apr 2009 18:53:49 UTC
Last Modification Date: 22 Apr 2009 18:53:49 UTC
Creation Date: 22 Apr 2009 18:53:49 UTC
bqbiol:occursIn Brenda Tissue Ontology sinus node
bqbiol:hasTaxon Taxonomy Mammalia
bqbiol:isVersionOf Gene Ontology SA node cell action potential
bqmodel:isDerivedFrom PubMed 6292407

This a model from the article:
A model of sino-atrial node electrical activity based on a modification of the DiFrancesco-Noble (1984) equations.
Noble D, Noble SJ. Proc R Soc Lond B Biol Sci. 1984 Sep 22;222(1228):295-304. 6149553 ,
DiFrancesco & Noble's (1984) equations (Phil. Trans. R. Soc. Lond. B (in the press.] have been modified to apply to the mammalian sino-atrial node. The modifications are based on recent experimental work. The modified equations successfully reproduce action potential and pacemaker activity in the node. Slightly different versions have been developed for peripheral regions that show a maximum diastolic potential near --75 mV and for central regions that do not hyperpolarize beyond --60 to --65 mV. Variations in extracellular potassium influence the frequency of pacemaker activity in the s.a. node model very much less than they do in the Purkinje fibre model. This corresponds well to the experimental observation that the node is less sensitive to external [K] than are Purkinje fibres. Activation of the Na-K exchange pump in the model by increasing intracellular sodium can suppress pacemaker activity. This phenomenon may contribute to the mechanism of overdrive suppression.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Noble D, Noble SJ. (1984) - version04
The original CellML model was created by:
Noble, Penny, J
Oxford University
Department of Physiology, Anatomy & Genetics

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