Pasek2006_VentricularCardioMyocytes

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Short description

This a model from the article:
The functional role of cardiac T-tubules explored in a model of rat ventricular myocytes.
Pásek M, Simurda J, Christé G. Philos Transact A Math Phys Eng Sci. 2006 May 15;364(1842):1187-206. 16608703 ,
Abstract:
The morphology of the cardiac transverse-axial tubular system (TATS) has been known for decades, but its function has received little attention. To explore the possible role of this system in the physiological modulation of electrical and contractile activity, we have developed a mathematical model of rat ventricular cardiomyocytes in which the TATS is described as a single compartment. The geometrical characteristics of the TATS, the biophysical characteristics of ion transporters and their distribution between surface and tubular membranes were based on available experimental data. Biophysically realistic values of mean access resistance to the tubular lumen and time constants for ion exchange with the bulk extracellular solution were included. The fraction of membrane in the TATS was set to 56%. The action potentials initiated in current-clamp mode are accompanied by transient K+ accumulation and transient Ca2+ depletion in the TATS lumen. The amplitude of these changes relative to external ion concentrations was studied at steady-state stimulation frequencies of 1-5 Hz. Ca2+ depletion increased from 7 to 13.1% with stimulation frequency, while K+ accumulation decreased from 4.1 to 2.7%. These ionic changes (particularly Ca2+ depletion) implicated significant decrease of intracellular Ca2+ load at frequencies natural for rat heart.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Pásek M, Simurda J, Christé G. (2006) - version03
The original CellML model was created by:
Lloyd, Catherine, May
c.lloyd@aukland.ac.nz
The University of Auckland
The Bioengineering Institute

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
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Format
SBML (L2V3)
Related Publication
  • The functional role of cardiac T-tubules explored in a model of rat ventricular myocytes.
  • Pásek M, Simurda J, Christé G
  • Philosophical transactions. Series A, Mathematical, physical, and engineering sciences , 5/ 2006 , Volume 364 , pages: 1187-1206
  • Institute of Thermomechanics, Czech Academy of Science, Branch Brno, Technická, Brno, Czech Republic.
  • The morphology of the cardiac transverse-axial tubular system (TATS) has been known for decades, but its function has received little attention. To explore the possible role of this system in the physiological modulation of electrical and contractile activity, we have developed a mathematical model of rat ventricular cardiomyocytes in which the TATS is described as a single compartment. The geometrical characteristics of the TATS, the biophysical characteristics of ion transporters and their distribution between surface and tubular membranes were based on available experimental data. Biophysically realistic values of mean access resistance to the tubular lumen and time constants for ion exchange with the bulk extracellular solution were included. The fraction of membrane in the TATS was set to 56%. The action potentials initiated in current-clamp mode are accompanied by transient K+ accumulation and transient Ca2+ depletion in the TATS lumen. The amplitude of these changes relative to external ion concentrations was studied at steady-state stimulation frequencies of 1-5 Hz. Ca2+ depletion increased from 7 to 13.1% with stimulation frequency, while K+ accumulation decreased from 4.1 to 2.7%. These ionic changes (particularly Ca2+ depletion) implicated significant decrease of intracellular Ca2+ load at frequencies natural for rat heart.
Contributors
Vijayalakshmi Chelliah

Metadata information

is
BioModels Database MODEL0406553884
isDescribedBy
PubMed 16608703
hasTaxon
isVersionOf
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
occursIn
Brenda Tissue Ontology cardiac muscle fiber
Curation status
Non-curated
Original model(s)
http://www.cellml.org/models/pasek_simurda_christe_2006_version03
  • Model originally submitted by : Vijayalakshmi Chelliah
  • Submitted: 29-Apr-2009 11:31:47
  • Last Modified: 29-Apr-2009 11:31:47
Revisions
  • Version: 2 public model Download this version
    • Submitted on: 29-Apr-2009 11:31:47
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Current version of Pasek2006_VentricularCardioMyocytes
  • Version: 1 public model Download this version
    • Submitted on: 29-Apr-2009 11:31:47
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Original import of Pasek2006_VentricularCardioMyocytes