Pasek2008_VentricularCardioMyocyte

  public model
Short description

This a model from the article:
A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system.
Pásek M, Simurda J, Orchard CH, Christé G. Prog Biophys Mol Biol. 2008 Jan-Apr;96(1-3):258-80. 17888503 ,
Abstract:
A model of the guinea-pig cardiac ventricular myocyte has been developed that includes a representation of the transverse-axial tubular system (TATS), including heterogeneous distribution of ion flux pathways between the surface and tubular membranes. The model reproduces frequency-dependent changes of action potential shape and intracellular ion concentrations and can replicate experimental data showing ion diffusion between the tubular lumen and external solution in guinea-pig myocytes. The model is stable at rest and during activity and returns to rested state after perturbation. Theoretical analysis and model simulations show that, due to tight electrical coupling, tubular and surface membranes behave as a homogeneous whole during voltage and current clamp (maximum difference 0.9 mV at peak tubular INa of -38 nA). However, during action potentials, restricted diffusion and ionic currents in TATS cause depletion of tubular Ca2+ and accumulation of tubular K+ (up to -19.8% and +3.4%, respectively, of bulk extracellular values, at 6 Hz). These changes, in turn, decrease ion fluxes across the TATS membrane and decrease sarcoplasmic reticulum (SR) Ca2+ load. Thus, the TATS plays a potentially important role in modulating the function of guinea-pig ventricular myocyte in physiological conditions.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Pásek M, Simurda J, Orchard CH, Christé G. (2008) - version03
The original CellML model was created by:
Lloyd, Catherine, May
c.lloyd@aukland.ac.nz
The University of Auckland
The Bioengineering Institute

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Format
SBML (L2V3)
Related Publication
  • A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system.
  • Pásek M, Simurda J, Orchard CH, Christé G
  • Progress in biophysics and molecular biology , 0/ 2008 , Volume 96 , pages: 258-280
  • Institute of Thermomechanics, Czech Academy of Science-branch Brno, Czech Republic.
  • A model of the guinea-pig cardiac ventricular myocyte has been developed that includes a representation of the transverse-axial tubular system (TATS), including heterogeneous distribution of ion flux pathways between the surface and tubular membranes. The model reproduces frequency-dependent changes of action potential shape and intracellular ion concentrations and can replicate experimental data showing ion diffusion between the tubular lumen and external solution in guinea-pig myocytes. The model is stable at rest and during activity and returns to rested state after perturbation. Theoretical analysis and model simulations show that, due to tight electrical coupling, tubular and surface membranes behave as a homogeneous whole during voltage and current clamp (maximum difference 0.9 mV at peak tubular INa of -38 nA). However, during action potentials, restricted diffusion and ionic currents in TATS cause depletion of tubular Ca2+ and accumulation of tubular K+ (up to -19.8% and +3.4%, respectively, of bulk extracellular values, at 6 Hz). These changes, in turn, decrease ion fluxes across the TATS membrane and decrease sarcoplasmic reticulum (SR) Ca2+ load. Thus, the TATS plays a potentially important role in modulating the function of guinea-pig ventricular myocyte in physiological conditions.
Contributors
Vijayalakshmi Chelliah

Metadata information

is
BioModels Database MODEL0406793751
isDescribedBy
PubMed 17888503
hasTaxon
Taxonomy Cavia porcellus
isVersionOf
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
occursIn
Brenda Tissue Ontology cardiac muscle fiber
Curation status
Non-curated
Original model(s)
http://www.cellml.org/models/pasek_simurda_orchard_christe_2008_version03
  • Model originally submitted by : Vijayalakshmi Chelliah
  • Submitted: 29-Apr-2009 11:33:41
  • Last Modified: 29-Apr-2009 11:33:41
Revisions
  • Version: 2 public model Download this version
    • Submitted on: 29-Apr-2009 11:33:41
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Current version of Pasek2008_VentricularCardioMyocyte
  • Version: 1 public model Download this version
    • Submitted on: 29-Apr-2009 11:33:41
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Original import of Pasek2008_VentricularCardioMyocyte