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MODEL0406793751 - Pasek2008_VentricularCardioMyocyte

 

The following model is part of the non-curated branch of BioModels Database. While the syntax of the model has been verified, its semantics remains unchecked. Any annotation present in the models is not a product of BioModels' annotators. We are doing our best to incorporate this model into the curated branch as soon as possible. In the meantime, we display only limited metadata here. For further information about the model, please download the SBML file.


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Reference Publication
Publication ID: 17888503
Pásek M, Simurda J, Orchard CH, Christé G.
A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system.
Prog. Biophys. Mol. Biol. 2008 Jan-Apr; 96(1-3): 258-280
Institute of Thermomechanics, Czech Academy of Science-branch Brno, Czech Republic.  [more]
Model
Original Model: CellML logo
Submitter: Vijayalakshmi Chelliah
Submission Date: 29 Apr 2009 11:33:41 UTC
Last Modification Date: 29 Apr 2009 11:33:41 UTC
Creation Date: 29 Apr 2009 11:33:41 UTC
Encoders:
bqmodel:isDerivedFrom PubMed 8285252
PubMed 10777735
PubMed 9487284
bqbiol:occursIn Brenda Tissue Ontology cardiac muscle fiber
bqbiol:hasTaxon Taxonomy Cavia porcellus
bqbiol:isVersionOf Gene Ontology cardiac muscle cell action potential
Notes

This a model from the article:
A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system.
Pásek M, Simurda J, Orchard CH, Christé G. Prog Biophys Mol Biol. 2008 Jan-Apr;96(1-3):258-80. 17888503 ,
Abstract:
A model of the guinea-pig cardiac ventricular myocyte has been developed that includes a representation of the transverse-axial tubular system (TATS), including heterogeneous distribution of ion flux pathways between the surface and tubular membranes. The model reproduces frequency-dependent changes of action potential shape and intracellular ion concentrations and can replicate experimental data showing ion diffusion between the tubular lumen and external solution in guinea-pig myocytes. The model is stable at rest and during activity and returns to rested state after perturbation. Theoretical analysis and model simulations show that, due to tight electrical coupling, tubular and surface membranes behave as a homogeneous whole during voltage and current clamp (maximum difference 0.9 mV at peak tubular INa of -38 nA). However, during action potentials, restricted diffusion and ionic currents in TATS cause depletion of tubular Ca2+ and accumulation of tubular K+ (up to -19.8% and +3.4%, respectively, of bulk extracellular values, at 6 Hz). These changes, in turn, decrease ion fluxes across the TATS membrane and decrease sarcoplasmic reticulum (SR) Ca2+ load. Thus, the TATS plays a potentially important role in modulating the function of guinea-pig ventricular myocyte in physiological conditions.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Pásek M, Simurda J, Orchard CH, Christé G. (2008) - version03
The original CellML model was created by:
Lloyd, Catherine, May
c.lloyd@aukland.ac.nz
The University of Auckland
The Bioengineering Institute

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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

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