Kyrylov2005_HPAaxis

  public model
Short description

This a model from the article:
Modeling robust oscillatory behavior of the hypothalamic-pituitary-adrenal axis.
Kyrylov V, Severyanova LA, Vieira A. IEEE Trans Biomed Eng. 2005 Dec;52(12):1977-83. 16366221 ,
Abstract:
A mathematical model of the hypothalamic-pituitary-adrenal (HPA) axis of the human endocrine system is proposed. This new model provides an improvement over previous models by introducing two nonlinear factors with physiological relevance: 1) a limit to gland size; 2) rejection of negative hormone concentrations. The result is that the new model is by far the most robust; e.g., it can tolerate at least -50% and +100% perturbations to any of its parameters. This high degree of robustness allows one, for the first time, to model features of the system such as circadian rhythm and response to hormone injections. In addition, relative to its closest predecessor, the model is simpler; it contains only about half of the parameters, and yet achieves more functions. The new model provides opportunities for teaching endocrinology within a biological or medical school context; it may also have applications in modeling and studying HPA axis disorders, for example, related to gland size dynamics, abnormal hormone levels, or stress influences.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Kyrylov V, Severyanova LA, Vieira A. (2005) - version02
The original CellML model was created by:
Lloyd, Catherine, May
c.lloyd@aukland.ac.nz
The University of Auckland
The Bioengineering Institute

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Format
SBML (L2V3)
Related Publication
  • Modeling robust oscillatory behavior of the hypothalamic-pituitary-adrenal axis.
  • Kyrylov V, Severyanova LA, Vieira A
  • IEEE transactions on bio-medical engineering , 12/ 2005 , Volume 52 , pages: 1977-1983
  • School of Interactive Arts & Technology, Simon Fraser University, Surrey, BC V3T 2W1, Canada. vkyrylov@sfu.ca
  • A mathematical model of the hypothalamic-pituitary-adrenal (HPA) axis of the human endocrine system is proposed. This new model provides an improvement over previous models by introducing two nonlinear factors with physiological relevance: 1) a limit to gland size; 2) rejection of negative hormone concentrations. The result is that the new model is by far the most robust; e.g., it can tolerate at least -50% and +100% perturbations to any of its parameters. This high degree of robustness allows one, for the first time, to model features of the system such as circadian rhythm and response to hormone injections. In addition, relative to its closest predecessor, the model is simpler; it contains only about half of the parameters, and yet achieves more functions. The new model provides opportunities for teaching endocrinology within a biological or medical school context; it may also have applications in modeling and studying HPA axis disorders, for example, related to gland size dynamics, abnormal hormone levels, or stress influences.
Contributors
Vijayalakshmi Chelliah

Metadata information

is
BioModels Database MODEL0478740924
isDescribedBy
PubMed 16366221
hasTaxon
Taxonomy Homo sapiens
isVersionOf
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
Curation status
Non-curated
Original model(s)
http://www.cellml.org/models/kyrylov_severyanova_vieira_2005_version02
  • Model originally submitted by : Vijayalakshmi Chelliah
  • Submitted: Apr 28, 2009 2:37:23 PM
  • Last Modified: Apr 28, 2009 2:37:23 PM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Apr 28, 2009 2:37:23 PM
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Current version of Kyrylov2005_HPAaxis
  • Version: 1 public model Download this version
    • Submitted on: Apr 28, 2009 2:37:23 PM
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Original import of Kyrylov2005_HPAaxis