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MODEL0478740924 - Kyrylov2005_HPAaxis


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Reference Publication
Publication ID: 16366221
Kyrylov V, Severyanova LA, Vieira A.
Modeling robust oscillatory behavior of the hypothalamic-pituitary-adrenal axis.
IEEE Trans Biomed Eng 2005 Dec; 52(12): 1977-1983
School of Interactive Arts & Technology, Simon Fraser University, Surrey, BC V3T 2W1, Canada.  [more]
Original Model: CellML logo
Submitter: Vijayalakshmi Chelliah
Submission Date: 28 Apr 2009 14:37:23 UTC
Last Modification Date: 28 Apr 2009 14:37:23 UTC
Creation Date: 28 Apr 2009 14:37:23 UTC
bqbiol:isVersionOf Gene Ontology regulation of endocrine process
bqbiol:hasTaxon Taxonomy Homo sapiens

This a model from the article:
Modeling robust oscillatory behavior of the hypothalamic-pituitary-adrenal axis.
Kyrylov V, Severyanova LA, Vieira A. IEEE Trans Biomed Eng. 2005 Dec;52(12):1977-83. 16366221 ,
A mathematical model of the hypothalamic-pituitary-adrenal (HPA) axis of the human endocrine system is proposed. This new model provides an improvement over previous models by introducing two nonlinear factors with physiological relevance: 1) a limit to gland size; 2) rejection of negative hormone concentrations. The result is that the new model is by far the most robust; e.g., it can tolerate at least -50% and +100% perturbations to any of its parameters. This high degree of robustness allows one, for the first time, to model features of the system such as circadian rhythm and response to hormone injections. In addition, relative to its closest predecessor, the model is simpler; it contains only about half of the parameters, and yet achieves more functions. The new model provides opportunities for teaching endocrinology within a biological or medical school context; it may also have applications in modeling and studying HPA axis disorders, for example, related to gland size dynamics, abnormal hormone levels, or stress influences.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Kyrylov V, Severyanova LA, Vieira A. (2005) - version02
The original CellML model was created by:
Lloyd, Catherine, May
The University of Auckland
The Bioengineering Institute

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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.