Luo1991_VentricularCardiacAction

  public model
Short description

This a model from the article:
A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction.
Luo CH, Rudy Y. Circ Res. 1991 Jun;68(6):1501-26. 1709839 ,
Abstract:
A mathematical model of the membrane action potential of the mammalian ventricular cell is introduced. The model is based, whenever possible, on recent single-cell and single-channel data and incorporates the possibility of changing extracellular potassium concentration [K]o. The fast sodium current, INa, is characterized by fast upstroke velocity (Vmax = 400 V/sec) and slow recovery from inactivation. The time-independent potassium current, IK1, includes a negative-slope phase and displays significant crossover phenomenon as [K]o is varied. The time-dependent potassium current, IK, shows only a minimal degree of crossover. A novel potassium current that activates at plateau potentials is included in the model. The simulated action potential duplicates the experimentally observed effects of changes in [K]o on action potential duration and rest potential. Physiological simulations focus on the interaction between depolarization and repolarization (i.e., premature stimulation). Results demonstrate the importance of the slow recovery of INa in determining the response of the cell. Simulated responses to periodic stimulation include monotonic Wenckebach patterns and alternans at normal [K]o, whereas at low [K]o nonmonotonic Wenckebach periodicities, aperiodic patterns, and enhanced supernormal excitability that results in unstable responses ("chaotic activity") are observed. The results are consistent with recent experimental observations, and the model simulations relate these phenomena to the underlying ionic channel kinetics.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Luo CH, Rudy Y. (1991) - version06
The original CellML model was created by:
Lloyd, Catherine, May
c.lloyd@aukland.ac.nz
The University of Auckland
The Bioengineering Institute

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Format
SBML (L2V3)
Related Publication
  • A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction.
  • Luo CH, Rudy Y
  • Circulation research , 6/ 1991 , Volume 68 , pages: 1501-1526
  • Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106.
  • A mathematical model of the membrane action potential of the mammalian ventricular cell is introduced. The model is based, whenever possible, on recent single-cell and single-channel data and incorporates the possibility of changing extracellular potassium concentration [K]o. The fast sodium current, INa, is characterized by fast upstroke velocity (Vmax = 400 V/sec) and slow recovery from inactivation. The time-independent potassium current, IK1, includes a negative-slope phase and displays significant crossover phenomenon as [K]o is varied. The time-dependent potassium current, IK, shows only a minimal degree of crossover. A novel potassium current that activates at plateau potentials is included in the model. The simulated action potential duplicates the experimentally observed effects of changes in [K]o on action potential duration and rest potential. Physiological simulations focus on the interaction between depolarization and repolarization (i.e., premature stimulation). Results demonstrate the importance of the slow recovery of INa in determining the response of the cell. Simulated responses to periodic stimulation include monotonic Wenckebach patterns and alternans at normal [K]o, whereas at low [K]o nonmonotonic Wenckebach periodicities, aperiodic patterns, and enhanced supernormal excitability that results in unstable responses ("chaotic activity") are observed. The results are consistent with recent experimental observations, and the model simulations relate these phenomena to the underlying ionic channel kinetics.
Contributors
Vijayalakshmi Chelliah

Metadata information

is
BioModels Database MODEL0479527919
isDescribedBy
PubMed 1709839
hasTaxon
Taxonomy Homo sapiens
isVersionOf
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
occursIn
Brenda Tissue Ontology cardiac muscle
Curation status
Non-curated
Original model(s)
http://www.cellml.org/models/luo_rudy_1991_version06
  • Model originally submitted by : Vijayalakshmi Chelliah
  • Submitted: 28-Apr-2009 16:48:55
  • Last Modified: 28-Apr-2009 16:48:55
Revisions
  • Version: 2 public model Download this version
    • Submitted on: 28-Apr-2009 16:48:55
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Current version of Luo1991_VentricularCardiacAction
  • Version: 1 public model Download this version
    • Submitted on: 28-Apr-2009 16:48:55
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Original import of Luo1991_VentricularCardiacAction