Luo1991_VentricularCardiacAction

  public model
Short description

This a model from the article:
A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction.
Luo CH, Rudy Y. Circ Res. 1991 Jun;68(6):1501-26. 1709839 ,
Abstract:
A mathematical model of the membrane action potential of the mammalian ventricular cell is introduced. The model is based, whenever possible, on recent single-cell and single-channel data and incorporates the possibility of changing extracellular potassium concentration [K]o. The fast sodium current, INa, is characterized by fast upstroke velocity (Vmax = 400 V/sec) and slow recovery from inactivation. The time-independent potassium current, IK1, includes a negative-slope phase and displays significant crossover phenomenon as [K]o is varied. The time-dependent potassium current, IK, shows only a minimal degree of crossover. A novel potassium current that activates at plateau potentials is included in the model. The simulated action potential duplicates the experimentally observed effects of changes in [K]o on action potential duration and rest potential. Physiological simulations focus on the interaction between depolarization and repolarization (i.e., premature stimulation). Results demonstrate the importance of the slow recovery of INa in determining the response of the cell. Simulated responses to periodic stimulation include monotonic Wenckebach patterns and alternans at normal [K]o, whereas at low [K]o nonmonotonic Wenckebach periodicities, aperiodic patterns, and enhanced supernormal excitability that results in unstable responses ("chaotic activity") are observed. The results are consistent with recent experimental observations, and the model simulations relate these phenomena to the underlying ionic channel kinetics.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Luo CH, Rudy Y. (1991) - version06
The original CellML model was created by:
Lloyd, Catherine, May
c.lloyd@aukland.ac.nz
The University of Auckland
The Bioengineering Institute

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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Format
SBML (L2V3)
Related Publication
  • A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction.
  • Luo CH, Rudy Y
  • Circulation research , 6/ 1991 , Volume 68 , pages: 1501-1526
  • Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106.
  • A mathematical model of the membrane action potential of the mammalian ventricular cell is introduced. The model is based, whenever possible, on recent single-cell and single-channel data and incorporates the possibility of changing extracellular potassium concentration [K]o. The fast sodium current, INa, is characterized by fast upstroke velocity (Vmax = 400 V/sec) and slow recovery from inactivation. The time-independent potassium current, IK1, includes a negative-slope phase and displays significant crossover phenomenon as [K]o is varied. The time-dependent potassium current, IK, shows only a minimal degree of crossover. A novel potassium current that activates at plateau potentials is included in the model. The simulated action potential duplicates the experimentally observed effects of changes in [K]o on action potential duration and rest potential. Physiological simulations focus on the interaction between depolarization and repolarization (i.e., premature stimulation). Results demonstrate the importance of the slow recovery of INa in determining the response of the cell. Simulated responses to periodic stimulation include monotonic Wenckebach patterns and alternans at normal [K]o, whereas at low [K]o nonmonotonic Wenckebach periodicities, aperiodic patterns, and enhanced supernormal excitability that results in unstable responses ("chaotic activity") are observed. The results are consistent with recent experimental observations, and the model simulations relate these phenomena to the underlying ionic channel kinetics.
Contributors
Vijayalakshmi Chelliah

Metadata information

is
BioModels Database MODEL0479527919
isDescribedBy
PubMed 1709839
hasTaxon
Taxonomy Homo sapiens
isVersionOf
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
occursIn
Brenda Tissue Ontology cardiac muscle
Curation status
Non-curated
Original model(s)
http://www.cellml.org/models/luo_rudy_1991_version06
Name Description Size Actions

Model files

MODEL0479527919_url.xml SBML L2V3 representation of Luo1991_VentricularCardiacAction 46.69 KB Preview | Download

Additional files

MODEL0479527919.svg Auto-generated Reaction graph (SVG) 851.00 bytes Preview | Download
MODEL0479527919.pdf Auto-generated PDF file 2.80 KB Preview | Download
MODEL0479527919-biopax3.owl Auto-generated BioPAX (Level 3) 2.00 KB Preview | Download
MODEL0479527919.xpp Auto-generated XPP file 9.83 KB Preview | Download
MODEL0479527919.png Auto-generated Reaction graph (PNG) 5.04 KB Preview | Download
MODEL0479527919.vcml Auto-generated VCML file 900.00 bytes Preview | Download
MODEL0479527919.m Auto-generated Octave file 12.57 KB Preview | Download
MODEL0479527919-biopax2.owl Auto-generated BioPAX (Level 2) 1.05 KB Preview | Download
MODEL0479527919_urn.xml Auto-generated SBML file with URNs 52.31 KB Preview | Download
MODEL0479527919.sci Auto-generated Scilab file 355.00 bytes Preview | Download

  • Model originally submitted by : Vijayalakshmi Chelliah
  • Submitted: Apr 28, 2009 4:48:55 PM
  • Last Modified: Apr 28, 2009 4:48:55 PM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Apr 28, 2009 4:48:55 PM
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Current version of Luo1991_VentricularCardiacAction
  • Version: 1 public model Download this version
    • Submitted on: Apr 28, 2009 4:48:55 PM
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Original import of Luo1991_VentricularCardiacAction