Lenbury1991_CortisolSecretionSystem

  public model
Short description

This a model from the article:
Modelling fluctuation phenomena in the plasma cortisol secretion system in normal man.
Lenbury Y, Pacheenburawana P. Biosystems. 1991;26(2):117-25. 1668715 ,
Abstract:
A system of three non-linear differential equations with exponential feedback terms is proposed to model the self-regulating cortisol secretion system and explain the fluctuation patterns observed in clinical data. It is shown that the model exhibits bifurcation and chaos patterns for a certain range of parametric values. This helps us to explain clinical observations and characterize different dynamic behaviors of the self-regulative system.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Lenbury Y, Pacheenburawana P. (1991) - version02
The original CellML model was created by:
Lloyd, Catherine, May
c.lloyd@aukland.ac.nz
The University of Auckland
The Bioengineering Institute

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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Format
SBML (L2V3)
Related Publication
  • Modelling fluctuation phenomena in the plasma cortisol secretion system in normal man.
  • Lenbury Y, Pacheenburawana P
  • Bio Systems , 0/ 1991 , Volume 26 , pages: 117-125
  • Department of Mathematics, Faculty of Science, Mahidol University, Bangkok, Thailand.
  • A system of three non-linear differential equations with exponential feedback terms is proposed to model the self-regulating cortisol secretion system and explain the fluctuation patterns observed in clinical data. It is shown that the model exhibits bifurcation and chaos patterns for a certain range of parametric values. This helps us to explain clinical observations and characterize different dynamic behaviors of the self-regulative system.
Contributors
Vijayalakshmi Chelliah

Metadata information

is
BioModels Database MODEL0479926177
isDescribedBy
PubMed 1668715
hasTaxon
Taxonomy Homo sapiens
isVersionOf
Gene Ontology cortisol secretion
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
Curation status
Non-curated
Original model(s)
http://www.cellml.org/models/lenbury_pacheenburawana_1991_version02
  • Model originally submitted by : Vijayalakshmi Chelliah
  • Submitted: 28-Apr-2009 12:54:17
  • Last Modified: 28-Apr-2009 12:54:17
Revisions
  • Version: 2 public model Download this version
    • Submitted on: 28-Apr-2009 12:54:17
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Current version of Lenbury1991_CortisolSecretionSystem
  • Version: 1 public model Download this version
    • Submitted on: 28-Apr-2009 12:54:17
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Original import of Lenbury1991_CrotisolSecretionSystem