Kurata2002_SinoatrialNode

  public model
Short description

This a model from the article:
Dynamical description of sinoatrial node pacemaking: improved mathematical model for primary pacemaker cell.
Kurata Y, Hisatome I, Imanishi S, Shibamoto T. Am J Physiol Heart Circ Physiol 2002 Nov;283(5):H2074-101 12384487 ,
Abstract:
We developed an improved mathematical model for a single primary pacemaker cell of the rabbit sinoatrial node. Original features of our model include 1) incorporation of the sustained inward current (I(st)) recently identified in primary pacemaker cells, 2) reformulation of voltage- and Ca(2+)-dependent inactivation of the L-type Ca(2+) channel current (I(Ca,L)), 3) new expressions for activation kinetics of the rapidly activating delayed rectifier K(+) channel current (I(Kr)), and 4) incorporation of the subsarcolemmal space as a diffusion barrier for Ca(2+). We compared the simulated dynamics of our model with those of previous models, as well as with experimental data, and examined whether the models could accurately simulate the effects of modulating sarcolemmal ionic currents or intracellular Ca(2+) dynamics on pacemaker activity. Our model represents significant improvements over the previous models, because it can 1) simulate whole cell voltage-clamp data for I(Ca,L), I(Kr), and I(st); 2) reproduce the waveshapes of spontaneous action potentials and ionic currents during action potential clamp recordings; and 3) mimic the effects of channel blockers or Ca(2+) buffers on pacemaker activity more accurately than the previous models.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Kurata Y, Hisatome I, Imanishi S, Shibamoto T. (2002) - version05
The original CellML model was created by:
Noble, Penny,
penny.noble@dpag.ox.ac.uk
The University of Oxford

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Format
SBML (L2V3)
Related Publication
  • Dynamical description of sinoatrial node pacemaking: improved mathematical model for primary pacemaker cell.
  • Kurata Y, Hisatome I, Imanishi S, Shibamoto T
  • American journal of physiology. Heart and circulatory physiology , 11/ 2002 , Volume 283 , pages: H2074-101
  • Department of Physiology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-0293, Japan. yasu@kanazawa-med.ac.jp
  • We developed an improved mathematical model for a single primary pacemaker cell of the rabbit sinoatrial node. Original features of our model include 1) incorporation of the sustained inward current (I(st)) recently identified in primary pacemaker cells, 2) reformulation of voltage- and Ca(2+)-dependent inactivation of the L-type Ca(2+) channel current (I(Ca,L)), 3) new expressions for activation kinetics of the rapidly activating delayed rectifier K(+) channel current (I(Kr)), and 4) incorporation of the subsarcolemmal space as a diffusion barrier for Ca(2+). We compared the simulated dynamics of our model with those of previous models, as well as with experimental data, and examined whether the models could accurately simulate the effects of modulating sarcolemmal ionic currents or intracellular Ca(2+) dynamics on pacemaker activity. Our model represents significant improvements over the previous models, because it can 1) simulate whole cell voltage-clamp data for I(Ca,L), I(Kr), and I(st); 2) reproduce the waveshapes of spontaneous action potentials and ionic currents during action potential clamp recordings; and 3) mimic the effects of channel blockers or Ca(2+) buffers on pacemaker activity more accurately than the previous models.
Contributors
Vijayalakshmi Chelliah

Metadata information

is
BioModels Database MODEL0847712949
isDescribedBy
PubMed 12384487
hasTaxon
isVersionOf
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
occursIn
Brenda Tissue Ontology sinus node
Curation status
Non-curated
Original model(s)
http://www.cellml.org/models/kurata_hisatome_imanishi_shibamoto_2002_version05
  • Model originally submitted by : Vijayalakshmi Chelliah
  • Submitted: Apr 29, 2009 11:25:55 AM
  • Last Modified: Apr 29, 2009 11:25:55 AM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Apr 29, 2009 11:25:55 AM
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Current version of Kurata2002_SinoatrialNode
  • Version: 1 public model Download this version
    • Submitted on: Apr 29, 2009 11:25:55 AM
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Original import of Kurata2002_SinoatrialNode