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MODEL0847999575 - Iyer2004_VentricularMyocyte


The following model is part of the non-curated branch of BioModels Database. While the syntax of the model has been verified, its semantics remains unchecked. Any annotation present in the models is not a product of BioModels' annotators. We are doing our best to incorporate this model into the curated branch as soon as possible. In the meantime, we display only limited metadata here. For further information about the model, please download the SBML file.

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Reference Publication
Publication ID: 15345532
Iyer V, Mazhari R, Winslow RL.
A computational model of the human left-ventricular epicardial myocyte.
Biophys. J. 2004 Sep; 87(3): 1507-1525
The Center for Cardiovascular Bioinformatics and Modeling and the Whitaker Biomedical Engineering Institute, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, Maryland 21093, USA.  [more]
Original Model: CellML logo
Submitter: Vijayalakshmi Chelliah
Submission Date: 29 Apr 2009 13:02:35 UTC
Last Modification Date: 29 Apr 2009 13:02:35 UTC
Creation Date: 29 Apr 2009 13:02:35 UTC
bqbiol:occursIn Brenda Tissue Ontology cardiac muscle fiber
bqbiol:hasTaxon Taxonomy Homo sapiens
bqbiol:isVersionOf Gene Ontology cardiac muscle cell action potential

This a model from the article:
A computational model of the human left-ventricular epicardial myocyte.
Iyer V, Mazhari R, Winslow RL. Biophys J 2004 Sep;87(3):1507-25 15345532 ,
A computational model of the human left-ventricular epicardial myocyte is presented. Models of each of the major ionic currents present in these cells are formulated and validated using experimental data obtained from studies of recombinant human ion channels and/or whole-cell recording from single myocytes isolated from human left-ventricular subepicardium. Continuous-time Markov chain models for the gating of the fast Na(+) current, transient outward current, rapid component of the delayed rectifier current, and the L-type calcium current are modified to represent human data at physiological temperature. A new model for the gating of the slow component of the delayed rectifier current is formulated and validated against experimental data. Properties of calcium handling and exchanger currents are altered to appropriately represent the dynamics of intracellular ion concentrations. The model is able to both reproduce and predict a wide range of behaviors observed experimentally including action potential morphology, ionic currents, intracellular calcium transients, frequency dependence of action-potential duration, Ca(2+)-frequency relations, and extrasystolic restitution/post-extrasystolic potentiation. The model therefore serves as a useful tool for investigating mechanisms of arrhythmia and consequences of drug-channel interactions in the human left-ventricular myocyte.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Iyer V, Mazhari R, Winslow RL. (2004) - version04
The original CellML model was created by:
Niederer, Steven,
University of Oxford
Department of Physiology, Anatomy & Genetics

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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.