Iyer2004_VentricularMyocyte

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Short description

This a model from the article:
A computational model of the human left-ventricular epicardial myocyte.
Iyer V, Mazhari R, Winslow RL. Biophys J 2004 Sep;87(3):1507-25 15345532 ,
Abstract:
A computational model of the human left-ventricular epicardial myocyte is presented. Models of each of the major ionic currents present in these cells are formulated and validated using experimental data obtained from studies of recombinant human ion channels and/or whole-cell recording from single myocytes isolated from human left-ventricular subepicardium. Continuous-time Markov chain models for the gating of the fast Na(+) current, transient outward current, rapid component of the delayed rectifier current, and the L-type calcium current are modified to represent human data at physiological temperature. A new model for the gating of the slow component of the delayed rectifier current is formulated and validated against experimental data. Properties of calcium handling and exchanger currents are altered to appropriately represent the dynamics of intracellular ion concentrations. The model is able to both reproduce and predict a wide range of behaviors observed experimentally including action potential morphology, ionic currents, intracellular calcium transients, frequency dependence of action-potential duration, Ca(2+)-frequency relations, and extrasystolic restitution/post-extrasystolic potentiation. The model therefore serves as a useful tool for investigating mechanisms of arrhythmia and consequences of drug-channel interactions in the human left-ventricular myocyte.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Iyer V, Mazhari R, Winslow RL. (2004) - version04
The original CellML model was created by:
Niederer, Steven,
sn@dpag.ox.ac.uk
University of Oxford
Department of Physiology, Anatomy & Genetics

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Format
SBML (L2V3)
Related Publication
  • A computational model of the human left-ventricular epicardial myocyte.
  • Iyer V, Mazhari R, Winslow RL
  • Biophysical Journal , 9/ 2004 , Volume 87 , pages: 1507-1525
  • The Center for Cardiovascular Bioinformatics and Modeling and the Whitaker Biomedical Engineering Institute, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, Maryland 21093, USA.
  • A computational model of the human left-ventricular epicardial myocyte is presented. Models of each of the major ionic currents present in these cells are formulated and validated using experimental data obtained from studies of recombinant human ion channels and/or whole-cell recording from single myocytes isolated from human left-ventricular subepicardium. Continuous-time Markov chain models for the gating of the fast Na(+) current, transient outward current, rapid component of the delayed rectifier current, and the L-type calcium current are modified to represent human data at physiological temperature. A new model for the gating of the slow component of the delayed rectifier current is formulated and validated against experimental data. Properties of calcium handling and exchanger currents are altered to appropriately represent the dynamics of intracellular ion concentrations. The model is able to both reproduce and predict a wide range of behaviors observed experimentally including action potential morphology, ionic currents, intracellular calcium transients, frequency dependence of action-potential duration, Ca(2+)-frequency relations, and extrasystolic restitution/post-extrasystolic potentiation. The model therefore serves as a useful tool for investigating mechanisms of arrhythmia and consequences of drug-channel interactions in the human left-ventricular myocyte.
Contributors
Vijayalakshmi Chelliah

Metadata information

is
BioModels Database MODEL0847999575
isDescribedBy
PubMed 15345532
hasTaxon
Taxonomy Homo sapiens
isVersionOf
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
occursIn
Brenda Tissue Ontology cardiac muscle fiber
Curation status
Non-curated
Original model(s)
http://www.cellml.org/models/iyer_mazhari_winslow_2004_version04
  • Model originally submitted by : Vijayalakshmi Chelliah
  • Submitted: 29-Apr-2009 13:02:35
  • Last Modified: 29-Apr-2009 13:02:35
Revisions
  • Version: 2 public model Download this version
    • Submitted on: 29-Apr-2009 13:02:35
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Current version of Iyer2004_VentricularMyocyte
  • Version: 1 public model Download this version
    • Submitted on: 29-Apr-2009 13:02:35
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Original import of Iyer2004_VentricularMyocyte