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MODEL0848062679 - Irvine1999_CardiacSodiumChannel


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Reference Publication
Publication ID: 10096885
Irvine LA, Jafri MS, Winslow RL.
Cardiac sodium channel Markov model with temperature dependence and recovery from inactivation.
Biophys. J. 1999 Apr; 76(4): 1868-1885
Department of Biomedical Engineering, Center for Computational Medicine and Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.  [more]
Original Model: CellML logo
Submitter: Vijayalakshmi Chelliah
Submission Date: 29 Apr 2009 14:37:42 UTC
Last Modification Date: 29 Apr 2009 14:37:42 UTC
Creation Date: 29 Apr 2009 14:37:42 UTC
bqbiol:occursIn Brenda Tissue Ontology cardiac muscle fiber
bqbiol:hasTaxon Taxonomy Homo sapiens
bqbiol:isVersionOf Gene Ontology voltage-gated sodium channel activity involved in cardiac muscle cell action potential
bqmodel:isDerivedFrom PubMed 8161454

This a model from the article:
Cardiac sodium channel Markov model with temperature dependence and recovery from inactivation.
Irvine LA, Jafri MS, Winslow RL. Biophys J 1999 Apr;76(4):1868-85 10096885 ,
A Markov model of the cardiac sodium channel is presented. The model is similar to the CA1 hippocampal neuron sodium channel model developed by Kuo and Bean (1994. Neuron. 12:819-829) with the following modifications: 1) an additional open state is added; 2) open-inactivated transitions are made voltage-dependent; and 3) channel rate constants are exponential functions of enthalpy, entropy, and voltage and have explicit temperature dependence. Model parameters are determined using a simulated annealing algorithm to minimize the error between model responses and various experimental data sets. The model reproduces a wide range of experimental data including ionic currents, gating currents, tail currents, steady-state inactivation, recovery from inactivation, and open time distributions over a temperature range of 10 degrees C to 25 degrees C. The model also predicts measures of single channel activity such as first latency, probability of a null sweep, and probability of reopening.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Irvine LA, Jafri MS, Winslow RL. (1999) - version02
The original CellML model was created by:
Lloyd, Catherine, May
The University of Auckland
The Bioengineering Institute

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