Irvine1999_CardiacSodiumChannel

  public model
Short description

This a model from the article:
Cardiac sodium channel Markov model with temperature dependence and recovery from inactivation.
Irvine LA, Jafri MS, Winslow RL. Biophys J 1999 Apr;76(4):1868-85 10096885 ,
Abstract:
A Markov model of the cardiac sodium channel is presented. The model is similar to the CA1 hippocampal neuron sodium channel model developed by Kuo and Bean (1994. Neuron. 12:819-829) with the following modifications: 1) an additional open state is added; 2) open-inactivated transitions are made voltage-dependent; and 3) channel rate constants are exponential functions of enthalpy, entropy, and voltage and have explicit temperature dependence. Model parameters are determined using a simulated annealing algorithm to minimize the error between model responses and various experimental data sets. The model reproduces a wide range of experimental data including ionic currents, gating currents, tail currents, steady-state inactivation, recovery from inactivation, and open time distributions over a temperature range of 10 degrees C to 25 degrees C. The model also predicts measures of single channel activity such as first latency, probability of a null sweep, and probability of reopening.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Irvine LA, Jafri MS, Winslow RL. (1999) - version02
The original CellML model was created by:
Lloyd, Catherine, May
c.lloyd@aukland.ac.nz
The University of Auckland
The Bioengineering Institute

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Format
SBML (L2V3)
Related Publication
  • Cardiac sodium channel Markov model with temperature dependence and recovery from inactivation.
  • Irvine LA, Jafri MS, Winslow RL
  • Biophysical Journal , 4/ 1999 , Volume 76 , pages: 1868-1885
  • Department of Biomedical Engineering, Center for Computational Medicine and Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
  • A Markov model of the cardiac sodium channel is presented. The model is similar to the CA1 hippocampal neuron sodium channel model developed by Kuo and Bean (1994. Neuron. 12:819-829) with the following modifications: 1) an additional open state is added; 2) open-inactivated transitions are made voltage-dependent; and 3) channel rate constants are exponential functions of enthalpy, entropy, and voltage and have explicit temperature dependence. Model parameters are determined using a simulated annealing algorithm to minimize the error between model responses and various experimental data sets. The model reproduces a wide range of experimental data including ionic currents, gating currents, tail currents, steady-state inactivation, recovery from inactivation, and open time distributions over a temperature range of 10 degrees C to 25 degrees C. The model also predicts measures of single channel activity such as first latency, probability of a null sweep, and probability of reopening.
Contributors
Vijayalakshmi Chelliah

Metadata information

is
BioModels Database MODEL0848062679
isDescribedBy
PubMed 10096885
hasTaxon
Taxonomy Homo sapiens
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
occursIn
Brenda Tissue Ontology cardiac muscle fiber
Curation status
Non-curated
Original model(s)
http://www.cellml.org/models/irvine_jafri_winslow_1999_version02
  • Model originally submitted by : Vijayalakshmi Chelliah
  • Submitted: Apr 29, 2009 2:37:42 PM
  • Last Modified: Apr 29, 2009 2:37:42 PM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Apr 29, 2009 2:37:42 PM
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Current version of Irvine1999_CardiacSodiumChannel
  • Version: 1 public model Download this version
    • Submitted on: Apr 29, 2009 2:37:42 PM
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Original import of Irvine1999_CardiacSodiumChannel