Hinch2004_VentricularMyocytes

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Short description

This a model from the article:
A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes.
Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL. Biophys J 2004 Dec;87(6):3723-36 15465866 ,
Abstract:
Calcium (Ca2+)-induced Ca2+ release (CICR) in cardiac myocytes exhibits high gain and is graded. These properties result from local control of Ca2+ release. Existing local control models of Ca2+ release in which interactions between L-Type Ca2+ channels (LCCs) and ryanodine-sensitive Ca2+ release channels (RyRs) are simulated stochastically are able to reconstruct these properties, but only at high computational cost. Here we present a general analytical approach for deriving simplified models of local control of CICR, consisting of low-dimensional systems of coupled ordinary differential equations, from these more complex local control models in which LCC-RyR interactions are simulated stochastically. The resulting model, referred to as the coupled LCC-RyR gating model, successfully reproduces a range of experimental data, including L-Type Ca2+ current in response to voltage-clamp stimuli, inactivation of LCC current with and without Ca2+ release from the sarcoplasmic reticulum, voltage-dependence of excitation-contraction coupling gain, graded release, and the force-frequency relationship. The model does so with low computational cost.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL. (2004) - version02
The original CellML model was created by:
Terkildsen, Jonna,
j.terkildsen@auckland.ac.nz
University of Auckland
Auckland Bioengineering Institute

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Format
SBML (L2V3)
Related Publication
  • A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes.
  • Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL
  • Biophysical Journal , 12/ 2004 , Volume 87 , pages: 3723-3736
  • Mathematical Institute, University of Oxford, Oxford, United Kingdom. hinch@maths.ox.ac.uk
  • Calcium (Ca2+)-induced Ca2+ release (CICR) in cardiac myocytes exhibits high gain and is graded. These properties result from local control of Ca2+ release. Existing local control models of Ca2+ release in which interactions between L-Type Ca2+ channels (LCCs) and ryanodine-sensitive Ca2+ release channels (RyRs) are simulated stochastically are able to reconstruct these properties, but only at high computational cost. Here we present a general analytical approach for deriving simplified models of local control of CICR, consisting of low-dimensional systems of coupled ordinary differential equations, from these more complex local control models in which LCC-RyR interactions are simulated stochastically. The resulting model, referred to as the coupled LCC-RyR gating model, successfully reproduces a range of experimental data, including L-Type Ca2+ current in response to voltage-clamp stimuli, inactivation of LCC current with and without Ca2+ release from the sarcoplasmic reticulum, voltage-dependence of excitation-contraction coupling gain, graded release, and the force-frequency relationship. The model does so with low computational cost.
Contributors
Vijayalakshmi Chelliah

Metadata information

is
BioModels Database MODEL0848342500
isDescribedBy
PubMed 15465866
hasTaxon
Taxonomy Homo sapiens
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
occursIn
Brenda Tissue Ontology cardiac muscle fiber
Curation status
Non-curated
Original model(s)
http://www.cellml.org/models/hinch_greenstein_tanskanen_xu_winslow_2004_version02
  • Model originally submitted by : Vijayalakshmi Chelliah
  • Submitted: Apr 28, 2009 1:26:10 PM
  • Last Modified: Apr 28, 2009 1:26:10 PM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Apr 28, 2009 1:26:10 PM
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Current version of Hinch2004_VentricularMyocytes
  • Version: 1 public model Download this version
    • Submitted on: Apr 28, 2009 1:26:10 PM
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Original import of Hinch2004_VentricularMyocytes