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MODEL0848342500 - Hinch2004_VentricularMyocytes


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Reference Publication
Publication ID: 15465866
Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL.
A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes.
Biophys. J. 2004 Dec; 87(6): 3723-3736
Mathematical Institute, University of Oxford, Oxford, United Kingdom.  [more]
Original Model: CellML logo
Submitter: Vijayalakshmi Chelliah
Submission Date: 28 Apr 2009 13:26:10 UTC
Last Modification Date: 28 Apr 2009 13:26:10 UTC
Creation Date: 28 Apr 2009 13:26:10 UTC
bqmodel:isDerivedFrom PubMed 14990462
PubMed 12496068
bqbiol:occursIn Brenda Tissue Ontology cardiac muscle fiber
bqbiol:hasTaxon Taxonomy Homo sapiens
bqbiol:isVersionOf Gene Ontology regulation of cardiac muscle cell action potential

This a model from the article:
A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes.
Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL. Biophys J 2004 Dec;87(6):3723-36 15465866 ,
Calcium (Ca2+)-induced Ca2+ release (CICR) in cardiac myocytes exhibits high gain and is graded. These properties result from local control of Ca2+ release. Existing local control models of Ca2+ release in which interactions between L-Type Ca2+ channels (LCCs) and ryanodine-sensitive Ca2+ release channels (RyRs) are simulated stochastically are able to reconstruct these properties, but only at high computational cost. Here we present a general analytical approach for deriving simplified models of local control of CICR, consisting of low-dimensional systems of coupled ordinary differential equations, from these more complex local control models in which LCC-RyR interactions are simulated stochastically. The resulting model, referred to as the coupled LCC-RyR gating model, successfully reproduces a range of experimental data, including L-Type Ca2+ current in response to voltage-clamp stimuli, inactivation of LCC current with and without Ca2+ release from the sarcoplasmic reticulum, voltage-dependence of excitation-contraction coupling gain, graded release, and the force-frequency relationship. The model does so with low computational cost.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL. (2004) - version02
The original CellML model was created by:
Terkildsen, Jonna,
University of Auckland
Auckland Bioengineering Institute

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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.