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Hinch2004_VentricularMyocytes

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Short description

This a model from the article:
A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes.
Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL. Biophys J2004 Dec;87(6):3723-36 15465866,
Abstract:
Calcium (Ca2+)-induced Ca2+ release (CICR) in cardiac myocytes exhibits high gain and is graded. These properties result from local control of Ca2+ release. Existing local control models of Ca2+ release in which interactions between L-Type Ca2+ channels (LCCs) and ryanodine-sensitive Ca2+ release channels (RyRs) are simulated stochastically are able to reconstruct these properties, but only at high computational cost. Here we present a general analytical approach for deriving simplified models of local control of CICR, consisting of low-dimensional systems of coupled ordinary differential equations, from these more complex local control models in which LCC-RyR interactions are simulated stochastically. The resulting model, referred to as the coupled LCC-RyR gating model, successfully reproduces a range of experimental data, including L-Type Ca2+ current in response to voltage-clamp stimuli, inactivation of LCC current with and without Ca2+ release from the sarcoplasmic reticulum, voltage-dependence of excitation-contraction coupling gain, graded release, and the force-frequency relationship. The model does so with low computational cost.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL. (2004) - version02
The original CellML model was created by:
Terkildsen, Jonna,
j.terkildsen@auckland.ac.nz
University of Auckland
Auckland Bioengineering Institute

Format
SBML (L2V1)
Related Publication
  • A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes.
  • Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL
  • Biophysical Journal , 12/ 2004 , Volume 87 , pages: 3723-3736
  • Mathematical Institute, University of Oxford, Oxford, United Kingdom. hinch@maths.ox.ac.uk
  • Calcium (Ca2+)-induced Ca2+ release (CICR) in cardiac myocytes exhibits high gain and is graded. These properties result from local control of Ca2+ release. Existing local control models of Ca2+ release in which interactions between L-Type Ca2+ channels (LCCs) and ryanodine-sensitive Ca2+ release channels (RyRs) are simulated stochastically are able to reconstruct these properties, but only at high computational cost. Here we present a general analytical approach for deriving simplified models of local control of CICR, consisting of low-dimensional systems of coupled ordinary differential equations, from these more complex local control models in which LCC-RyR interactions are simulated stochastically. The resulting model, referred to as the coupled LCC-RyR gating model, successfully reproduces a range of experimental data, including L-Type Ca2+ current in response to voltage-clamp stimuli, inactivation of LCC current with and without Ca2+ release from the sarcoplasmic reticulum, voltage-dependence of excitation-contraction coupling gain, graded release, and the force-frequency relationship. The model does so with low computational cost.
Contributors
Vijayalakshmi Chelliah

Metadata information

Curation status
Non-curated
  • Model originally submitted by : Vijayalakshmi Chelliah
  • Submitted: Apr 28, 2009 1:26:10 PM
  • Last Modified: Apr 28, 2009 1:26:10 PM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Apr 28, 2009 1:26:10 PM
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Current version of Hinch2004_VentricularMyocytes
  • Version: 1 public model Download this version
    • Submitted on: Apr 28, 2009 1:26:10 PM
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Original import of Hinch2004_VentricularMyocytes