Thiele2013 - Human metabolism global reconstruction (Recon 2)

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Short description
Thiele2013 - Human metabolism global reconstruction (Recon 2)

Community-driven global reconstruction of human metabolism (version 2.02).

This model is described in the article:

Thiele I, et al.
Nature Biotechnology

Abstract:

Multiple models of human metabolism have been reconstructed, but each represents only a subset of our knowledge. Here we describe Recon 2, a community-driven, consensus 'metabolic reconstruction', which is the most comprehensive representation of human metabolism that is applicable to computational modeling. Compared with its predecessors, the reconstruction has improved topological and functional features, including ~2x more reactions and ~1.7x more unique metabolites. Using Recon 2 we predicted changes in metabolite biomarkers for 49 inborn errors of metabolism with 77% accuracy when compared to experimental data. Mapping metabolomic data and drug information onto Recon 2 demonstrates its potential for integrating and analyzing diverse data types. Using protein expression data, we automatically generated a compendium of 65 cell type-specific models, providing a basis for manual curation or investigation of cell-specific metabolic properties. Recon 2 will facilitate many future biomedical studies and is freely available at http://humanmetabolism.org/.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Format
SBML (L2V4)
Related Publication
  • A community-driven global reconstruction of human metabolism.
  • Thiele I, Swainston N, Fleming RM, Hoppe A, Sahoo S, Aurich MK, Haraldsdottir H, Mo ML, Rolfsson O, Stobbe MD, Thorleifsson SG, Agren R, Bölling C, Bordel S, Chavali AK, Dobson P, Dunn WB, Endler L, Hala D, Hucka M, Hull D, Jameson D, Jamshidi N, Jonsson JJ, Juty N, Keating SM, Nookaew I, Le Novère N, Malys N, Mazein A, Papin JA, Price ND, Selkov E Sr, Sigurdsson MI, Simeonidis E, Sonnenschein N, Smallbone K, Sorokin A, van Beek JH, Weichart D, Goryanin I, Nielsen J, Westerhoff HV, Kell DB, Mendes P, Palsson BØ
  • Nature biotechnology , 5/ 2013 , Volume 31 , pages: 419-425
  • Center for Systems Biology, University of Iceland, Reykjavik, Iceland. ines.thiele@gmail.com
  • Multiple models of human metabolism have been reconstructed, but each represents only a subset of our knowledge. Here we describe Recon 2, a community-driven, consensus 'metabolic reconstruction', which is the most comprehensive representation of human metabolism that is applicable to computational modeling. Compared with its predecessors, the reconstruction has improved topological and functional features, including ∼2× more reactions and ∼1.7× more unique metabolites. Using Recon 2 we predicted changes in metabolite biomarkers for 49 inborn errors of metabolism with 77% accuracy when compared to experimental data. Mapping metabolomic data and drug information onto Recon 2 demonstrates its potential for integrating and analyzing diverse data types. Using protein expression data, we automatically generated a compendium of 65 cell type-specific models, providing a basis for manual curation or investigation of cell-specific metabolic properties. Recon 2 will facilitate many future biomedical studies and is freely available at http://humanmetabolism.org/.
Contributors
Nicolas Le Novère

Metadata information

is
BioModels Database MODEL1109130000
occursIn
Taxonomy Homo sapiens
isVersionOf
Curation status
Non-curated
  • Model originally submitted by : Nicolas Le Novère
  • Submitted: Sep 13, 2011 12:31:16 PM
  • Last Modified: Aug 29, 2013 11:51:33 AM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Aug 29, 2013 11:51:33 AM
    • Submitted by: Nicolas Le Novère
    • With comment: Current version of Thiele2013 - Human metabolism global reconstruction (Recon 2)
  • Version: 1 public model Download this version
    • Submitted on: Sep 13, 2011 12:31:16 PM
    • Submitted by: Nicolas Le Novère
    • With comment: Original import of Recon 2