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MODEL1208030000 - Mandlik2013 - Synthetic circuit of IPC synthase in Leishmania


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Reference Publication
Publication ID: 24386012
Mandlik V, Limbachiya D, Shinde S, Mol M, Singh S.
Synthetic circuit of inositol phosphorylceramide synthase in Leishmania : a chemical biology approach.
J Chem Biol 2013; 6(2): 51-62
National Centre for Cell Science, NCCS Complex, Ganeshkhind, Pune University Campus, Pune, 411007 India.  [more]
Original Model: MODEL1208030000.origin
Submitter: Vijayalakshmi Chelliah
Submission Date: 03 Aug 2012 11:51:13 UTC
Last Modification Date: 27 Feb 2013 11:33:39 UTC
Creation Date: 27 Feb 2013 11:33:39 UTC
bqbiol:isVersionOf Gene Ontology response to other organism
Human Disease Ontology leishmaniasis
bqbiol:hasTaxon Taxonomy Leishmania
Mandlik2012 - Synthetic circuit of IPC synthase in Leishmania

A genetic circuit for the targeted enzyme inositol phosphorylceramide (IPC) synthase belonging to the protozoan parasite Leishmania is constructed by Mandlik et al. (2013).

This model is described in the article:

Mandlik V., Limbachiya D., Shinde S., Mol M, S., Singh, S.
J Chem Biol. January 2013


Building circuits and studying their behavior in cells is a major goal of systems and synthetic biology. Synthetic biology enables the precise control of cellular states for systems studies, the discovery of novel parts, control strategies, and interactions for the design of robust synthetic systems. To the best of our knowledge, there are no literature reports for the synthetic circuit construction for protozoan parasites. This paper describes the construction of genetic circuit for the targeted enzyme inositol phosphorylceramide synthase belonging to the protozoan parasite Leishmania. To explore the dynamic nature of the circuit designed, simulation was done followed by circuit validation by qualitative and quantitative approaches. The genetic circuit designed for inositol phosphorylceramide synthase (Biomodels Database—MODEL1208030000) shows responsiveness, oscillatory and bistable behavior, together with intrinsic robustness.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.