Karlstaedt2012 - CardioNet, A Human Metabolic Network

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Karlstaedt2012 - CardioNet, A Human Metabolic Network

CardioNet is a functionally validated metabolic network of the human cardiomyocyte that enables theorectical studies of cellular metabolic processes.

This model is described in the article:

Karlstaedt A, Fliegner D, Kararigas G, Ruderisch HS, Regitz-Zagrosek V, Holzhütter HG.
BMC Syst Biol. 2012 Aug 29;6(1):114.

Abstract:

BACKGROUND: Availability of oxygen and nutrients in the coronary circulation is a crucial determinant of cardiac performance. Nutrient composition of coronary blood may significantly vary in specific physiological and pathological conditions, for example, administration of special diets, long-term starvation, physical exercise or diabetes. Quantitative analysis of cardiac metabolism from a systems biology perspective may help to a better understanding of the relationship between nutrient supply and efficiency of metabolic processes required for an adequate cardiac output. RESULTS: Here we present CardioNet, the first large-scale reconstruction of the metabolic network of the human cardiomyocyte comprising 1793 metabolic reactions, including 560 transport processes in six compartments. We use flux-balance analysis to demonstrate the capability of the network to accomplish a set of 368 metabolic functions required for maintaining the structural and functional integrity of the cell. Taking the maintenance of ATP, biosynthesis of ceramide, cardiolipin and further important phospholipids as examples, we analyse how a changed supply of glucose, lactate, fatty acids and ketone bodies may influence the efficiency of these essential processes. CONCLUSIONS: CardioNet is a functionally validated metabolic network of the human cardiomyocyte that enables theorectical studies of cellular metabolic processes crucial for the accomplishment of an adequate cardiac output.

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SBML (L2V4)
Related Publication
  • CardioNet: a human metabolic network suited for the study of cardiomyocyte metabolism.
  • Karlstädt A, Fliegner D, Kararigas G, Ruderisch HS, Regitz-Zagrosek V, Holzhütter HG
  • BMC systems biology , 0/ 2012 , Volume 6 , pages: 114
  • Institute of Biochemistry, Charité-Universitätsmedizin Berlin, Charitéplatz 1/Virchowweg 6, 10117 Berlin, Germany. anja.karlstaedt@charite.de
  • BACKGROUND: Availability of oxygen and nutrients in the coronary circulation is a crucial determinant of cardiac performance. Nutrient composition of coronary blood may significantly vary in specific physiological and pathological conditions, for example, administration of special diets, long-term starvation, physical exercise or diabetes. Quantitative analysis of cardiac metabolism from a systems biology perspective may help to a better understanding of the relationship between nutrient supply and efficiency of metabolic processes required for an adequate cardiac output. RESULTS: Here we present CardioNet, the first large-scale reconstruction of the metabolic network of the human cardiomyocyte comprising 1793 metabolic reactions, including 560 transport processes in six compartments. We use flux-balance analysis to demonstrate the capability of the network to accomplish a set of 368 metabolic functions required for maintaining the structural and functional integrity of the cell. Taking the maintenance of ATP, biosynthesis of ceramide, cardiolipin and further important phospholipids as examples, we analyse how a changed supply of glucose, lactate, fatty acids and ketone bodies may influence the efficiency of these essential processes. CONCLUSIONS: CardioNet is a functionally validated metabolic network of the human cardiomyocyte that enables theorectical studies of cellular metabolic processes crucial for the accomplishment of an adequate cardiac output.
Contributors
Anja Karlstaedt

Metadata information

is
BioModels Database MODEL1212040000
isDescribedBy
PubMed 22929619
hasTaxon
Taxonomy Homo sapiens
isVersionOf
occursIn
Brenda Tissue Ontology cardiac muscle fiber

Curation status
Non-curated

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  • Model originally submitted by : Anja Karlstaedt
  • Submitted: Dec 4, 2012 11:26:41 AM
  • Last Modified: Dec 5, 2012 11:49:43 AM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Dec 5, 2012 11:49:43 AM
    • Submitted by: Anja Karlstaedt
    • With comment: Current version of Karlstaedt2012 - CardioNet, A Human Metabolic Network
  • Version: 1 public model Download this version
    • Submitted on: Dec 4, 2012 11:26:41 AM
    • Submitted by: Anja Karlstaedt
    • With comment: Original import of CardioNet