Mufudza2012 - Estrogen effect on the dynamics of breast cancer

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Short description
Mufudza2012 - Estrogen effect on the dynamics of breast cancer
This deterministic model shows the dynamics of breast cancer with immune response. The effects of estrogen are incorporated to study its effects as a risk factor for the disease. 

This model is described in the article:

Mufudza C, Sorofa W, Chiyaka ET.
Comput Math Methods Med 2012; 2012: 473572

Abstract:

Worldwide, breast cancer has become the second most common cancer in women. The disease has currently been named the most deadly cancer in women but little is known on what causes the disease. We present the effects of estrogen as a risk factor on the dynamics of breast cancer. We develop a deterministic mathematical model showing general dynamics of breast cancer with immune response. This is a four-population model that includes tumor cells, host cells, immune cells, and estrogen. The effects of estrogen are then incorporated in the model. The results show that the presence of extra estrogen increases the risk of developing breast cancer.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Format
SBML (L2V4)
Related Publication
  • Assessing the effects of estrogen on the dynamics of breast cancer
  • Mufudza C, Sorofa W, Chiyaka ET
  • Computational and mathematical methods in medicine , 12/ 2012 , Volume 2012 , pages: 473572
  • Department of Applied Mathematics, National University of Science and Technology, Ascot, Bulawayo, Zimbabwe. chipmuf@gmail.com
  • Worldwide, breast cancer has become the second most common cancer in women. The disease has currently been named the most deadly cancer in women but little is known on what causes the disease. We present the effects of estrogen as a risk factor on the dynamics of breast cancer. We develop a deterministic mathematical model showing general dynamics of breast cancer with immune response. This is a four-population model that includes tumor cells, host cells, immune cells, and estrogen. The effects of estrogen are then incorporated in the model. The results show that the presence of extra estrogen increases the risk of developing breast cancer.
Contributors
administrator, Vijayalakshmi Chelliah

Metadata information

is
BioModels Database MODEL1304190001
BioModels Database BIOMD0000000642
isDescribedBy
PubMed 23365616
hasTaxon
Taxonomy Homo sapiens
hasProperty
Curation status
Curated
  • Model originally submitted by : administrator
  • Submitted: 19-Apr-2013 09:59:20
  • Last Modified: 06-Oct-2017 10:41:19
Revisions
  • Version: 3 public model Download this version
    • Submitted on: 06-Oct-2017 10:41:19
    • Submitted by: administrator
    • With comment: Update the model file
  • Version: 2 public model Download this version
    • Submitted on: 19-Apr-2013 12:01:25
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Current version of Mufudza2012 - Estrogen effect on the dynamics of breast cancer
  • Version: 1 public model Download this version
    • Submitted on: 19-Apr-2013 09:59:20
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Original import of Mufudza2012 - Estrogen effect on the dynamics of breast cancer
Curator's comment:
(added: 24 Aug 2017, 17:06:55, updated: 24 Aug 2017, 17:06:55)
Figure 3b of the reference publication has been reproduced. The model as such reproduces the plots corresponding to the excess estrogen condition. The simulations where performed and the plot was generated using Copasi 4.19 (Build 140).