Uhlén2015 - Human tissue-based proteome metabolic network - lung

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Short description
Uhlén2015 - Human tissue-based proteome metabolic network - lung
Human lung specific proteome metabolic network

This model is described in the article:

Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, Olsson I, Edllund K, Lundberg E, Navani S, Szigyarto AC, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist P, Berlin H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Pontén F.
Science 2015 January; 347(6220)

Abstract:

Resolving the molecular details of proteome variation in the different tissues and organs of the human body will greatly increase our knowledge of human biology and disease. Here, we present a map of the human tissue proteome based on an integrated omics approach that involves quantitative transcriptomics at the tissue and organ level, combined with tissue microarray–based immunohistochemistry, to achieve spatial localization of proteins down to the single-cell level. Our tissue-based analysis detected more than 90% of the putative protein-coding genes. We used this approach to explore the human secretome, the membrane proteome, the druggable proteome, the cancer proteome, and the metabolic functions in 32 different tissues and organs. All the data are integrated in an interactive Web-based database that allows exploration of individual proteins, as well as navigation of global expression patterns, in all major tissues and organs in the human body.

This model is hosted on BioModels Database and identified by: MODEL1411240011.

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Format
SBML (L2V3)
Related Publication
  • Proteomics. Tissue-based map of the human proteome.
  • Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist PH, Berling H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Pontén F
  • Science (New York, N.Y.) , 1/ 2015 , Volume 347 , pages: 1260419
  • Science for Life Laboratory, KTH-Royal Institute of Technology, SE-171 21 Stockholm, Sweden. Department of Proteomics, KTH-Royal Institute of Technology, SE-106 91 Stockholm, Sweden. Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2970 Hørsholm, Denmark. mathias.uhlen@scilifelab.se.
  • Resolving the molecular details of proteome variation in the different tissues and organs of the human body will greatly increase our knowledge of human biology and disease. Here, we present a map of the human tissue proteome based on an integrated omics approach that involves quantitative transcriptomics at the tissue and organ level, combined with tissue microarray-based immunohistochemistry, to achieve spatial localization of proteins down to the single-cell level. Our tissue-based analysis detected more than 90% of the putative protein-coding genes. We used this approach to explore the human secretome, the membrane proteome, the druggable proteome, the cancer proteome, and the metabolic functions in 32 different tissues and organs. All the data are integrated in an interactive Web-based database that allows exploration of individual proteins, as well as navigation of global expression patterns, in all major tissues and organs in the human body.
Contributors
Adil Mardinoglu

Metadata information

is
BioModels Database MODEL1411240011
hasTaxon
Taxonomy Homo sapiens
isVersionOf
occursIn
Brenda Tissue Ontology lung
Curation status
Non-curated
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  • Model originally submitted by : Adil Mardinoglu
  • Submitted: Nov 24, 2014 7:21:10 PM
  • Last Modified: Jan 27, 2015 9:13:42 PM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Jan 27, 2015 9:13:42 PM
    • Submitted by: Adil Mardinoglu
    • With comment: Current version of Uhlén2015 - Human tissue-based proteome metabolic network - lung
  • Version: 1 public model Download this version
    • Submitted on: Nov 24, 2014 7:21:10 PM
    • Submitted by: Adil Mardinoglu
    • With comment: Original import of MODEL1411240011.xml.origin