Uhlén2015 - Human tissue-based proteome metabolic network - tonsil

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Short description

This SBML representation of the Homo sapiens generic metabolic network is made available under the Creative Commons Attribution-Share Alike 3.0 Unported Licence (see www.creativecommons.org).

Related Publication
  • Proteomics. Tissue-based map of the human proteome.
  • Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist PH, Berling H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Pontén F
  • Science (New York, N.Y.) , 1/ 2015 , Volume 347 , pages: 1260419
  • Science for Life Laboratory, KTH-Royal Institute of Technology, SE-171 21 Stockholm, Sweden. Department of Proteomics, KTH-Royal Institute of Technology, SE-106 91 Stockholm, Sweden. Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2970 Hørsholm, Denmark. mathias.uhlen@scilifelab.se.
  • Resolving the molecular details of proteome variation in the different tissues and organs of the human body will greatly increase our knowledge of human biology and disease. Here, we present a map of the human tissue proteome based on an integrated omics approach that involves quantitative transcriptomics at the tissue and organ level, combined with tissue microarray-based immunohistochemistry, to achieve spatial localization of proteins down to the single-cell level. Our tissue-based analysis detected more than 90% of the putative protein-coding genes. We used this approach to explore the human secretome, the membrane proteome, the druggable proteome, the cancer proteome, and the metabolic functions in 32 different tissues and organs. All the data are integrated in an interactive Web-based database that allows exploration of individual proteins, as well as navigation of global expression patterns, in all major tissues and organs in the human body.
Adil Mardinoglu

Metadata information

BioModels Database MODEL1411240023
Taxonomy Homo sapiens
Brenda Tissue Ontology tonsil

Curation status

Name Description Size Actions

Model files

MODEL1411240023_url.xml SBML L2V3 representation of Uhlén2015 - Human tissue-based proteome metabolic network - tonsil 13.43 MB Preview | Download

Additional files

MODEL1411240023_urn.xml Auto-generated SBML file with URNs 13.50 MB Preview | Download
MODEL1411240023.png Auto-generated Reaction graph (PNG) 5.07 KB Preview | Download
MODEL1411240023-biopax2.owl Auto-generated BioPAX (Level 2) 17.77 MB Preview | Download
MODEL1411240023.vcml Auto-generated VCML file 964.00 bytes Preview | Download
MODEL1411240023.svg Auto-generated Reaction graph (SVG) 558.00 bytes Preview | Download
MODEL1411240023.sci Auto-generated Scilab file 167.00 bytes Preview | Download
MODEL1411240023-biopax3.owl Auto-generated BioPAX (Level 3) 30.13 MB Preview | Download

  • Model originally submitted by : Adil Mardinoglu
  • Submitted: Nov 24, 2014 10:19:53 PM
  • Last Modified: Jan 28, 2015 1:31:49 AM
  • Version: 2 public model Download this version
    • Submitted on: Jan 28, 2015 1:31:49 AM
    • Submitted by: Adil Mardinoglu
    • With comment: Current version of Uhlén2015 - Human tissue-based proteome metabolic network - tonsil
  • Version: 1 public model Download this version
    • Submitted on: Nov 24, 2014 10:19:53 PM
    • Submitted by: Adil Mardinoglu
    • With comment: Original import of MODEL1411240023.xml.origin