Kuroda2001_NO_cGMP_Pathway

  public model
Short description
This model of sGC is based on the paper by Kuroda S. et al. J Neurosci. (2001) 21(15):5693-702 . This models features the activation of sGC by NO, synthesis of cGMP, activity of PKG and PP2A in the synapse. The rates and concentrations have been taken from literature. It contains only the part described in figure 1B of the article.

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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Format
SBML (L2V1)
Related Publication
  • Exploration of signal transduction pathways in cerebellar long-term depression by kinetic simulation.
  • Kuroda S, Schweighofer N, Kawato M
  • The Journal of neuroscience : the official journal of the Society for Neuroscience , 8/ 2001 , Volume 21 , pages: 5693-5702
  • Kawato Dynamic Brain Project, ERATO, Japan Science and Technology, Kyoto 619-0288, Japan. kshinya@erato.atr.co.jp
  • Because multiple molecular signal transduction pathways regulate cerebellar long-term depression (LTD), which is thought to be a possible molecular and cellular basis of cerebellar learning, the systematic relationship between cerebellar LTD and the currently known signal transduction pathways remains obscure. To address this issue, we built a new diagram of signal transduction pathways and developed a computational model of kinetic simulation for the phosphorylation of AMPA receptors, known as a key step for expressing cerebellar LTD. The phosphorylation of AMPA receptors in this model consists of an initial phase and an intermediate phase. We show that the initial phase is mediated by the activation of linear cascades of protein kinase C (PKC), whereas the intermediate phase is mediated by a mitogen-activated protein (MAP) kinase-dependent positive feedback loop pathway that is responsible for the transition from the transient phosphorylation of the AMPA receptors to the stable phosphorylation of the AMPA receptors. These phases are dually regulated by the PKC and protein phosphatase pathways. Both phases also require nitric oxide (NO), although NO per se does not show any ability to induce LTD; this is consistent with a permissive role as reported experimentally (Lev-Ram et al., 1997). Therefore, the kinetic simulation is a powerful tool for understanding and exploring the behaviors of complex signal transduction pathways involved in cerebellar LTD.
Contributors
Sharat Vayttaden

Metadata information

is
BioModels Database MODEL4780181279
isDescribedBy
PubMed 11466441
hasTaxon
Taxonomy Homo sapiens
isVersionOf
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
occursIn
Brenda Tissue Ontology cerebellum
Curation status
Non-curated
Original model(s)
http://doqcs.ncbs.res.in/~doqcs/template.php?&y=accessiondetails&an=18
  • Model originally submitted by : Sharat Vayttaden
  • Submitted: 10-Sep-2008 11:02:17
  • Last Modified: 08-Oct-2009 12:52:05
Revisions
  • Version: 2 public model Download this version
    • Submitted on: 08-Oct-2009 12:52:05
    • Submitted by: Sharat Vayttaden
    • With comment: Current version of Kuroda2001_NO_cGMP_Pathway
  • Version: 1 public model Download this version
    • Submitted on: 10-Sep-2008 11:02:17
    • Submitted by: Sharat Vayttaden
    • With comment: Original import of Kuroda_GC