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AgedBrainSYSBIO: models related to neurodegenerative diseases

 

Here are all the models from the literature (curated and non-curated) which are related to: Alzheimer's disease , Huntington's disease , Parkinson's disease , amyotrophic lateral sclerosis , neurodegenerative disease and tauopathy .

Alzheimer's disease

Model name Publication Status  
Auer2010 - Correlation between lag time and aggregation rate in protein aggregation (BIOMD0000000555) Insight into the correlation between lag time and [...] curated model icon download icon
Crespo2012 - Kinetics of Amyloid Fibril Formation (BIOMD0000000531) A generic crystallization-like model that describe [...] curated model icon download icon
Das2010 - Effect of a gamma-secretase inhibitor on Amyloid-beta dynamics (BIOMD0000000551) Modeling effect of a γ-secretase inhibitor on amyl [...] curated model icon download icon
Ehrenstein1997 - The choline-leakage hypothesis in Alzheimer's disease (BIOMD0000000553) The choline-leakage hypothesis for the loss of ace [...] curated model icon download icon
Ehrenstein2000 - Positive-Feedback model for the loss of acetylcholine in Alzheimer's disease (BIOMD0000000552) A positive-feedback model for the loss of acetylch [...] curated model icon download icon
Krohn2011 - Cerebral amyloid-β proteostasis regulated by membrane transport protein ABCC1 (BIOMD0000000618) Cerebral amyloid-? proteostasis is regulated by th [...] curated model icon download icon
Lockwood2006_PKPD_AlzheimersDisease (MODEL1006230054) Application of clinical trial simulation to compar [...] non-curated model icon download icon
Martins2013 - True and apparent inhibition of amyloid fribril formation (BIOMD0000000561) True and apparent inhibition of amyloid fibril for [...] curated model icon download icon
Morris2008 - Fitting protein aggregation data via F-W 2-step mechanism (BIOMD0000000567) Fitting neurological protein aggregation kinetic d [...] curated model icon download icon
Ortega2013 - Interplay between secretases determines biphasic amyloid-beta level (BIOMD0000000556) Interplay between α-, β-, and γ-secretases determi [...] curated model icon download icon
Proctor2005 - Actions of chaperones and their role in ageing (BIOMD0000000091) Modelling the actions of chaperones and their role [...] curated model icon download icon
Proctor2010 - a link between GSK3 and p53 in Alzheimer's Disease (BIOMD0000000286) GSK3 and p53 - is there a link in Alzheimer's dise [...] curated model icon download icon
Proctor2012 - Role of Amyloid-beta dimers in aggregation formation (BIOMD0000000462) Aggregation, impaired degradation and immunization [...] curated model icon download icon
Proctor2013 - Effect of Aβ immunisation in Alzheimer's disease (deterministic version) (BIOMD0000000488) Investigating interventions in Alzheimer's disease [...] curated model icon download icon
Proctor2013 - Effect of Aβ immunisation in Alzheimer's disease (stochastic version) (BIOMD0000000634) Investigating interventions in Alzheimer's disease [...] curated model icon download icon
Reed2008_Glutathione_Metabolism (BIOMD0000000268) A mathematical model of glutathione metabolism. curated model icon download icon
Steckmann2012 - Amyloid beta-protein fibrillogenesis (kinetics of secondary structure conversion) (BIOMD0000000533) Kinetics of peptide secondary structure conversion [...] curated model icon download icon
Vazquez2014 - Chemical inhibition from amyloid protein aggregation kinetics (BIOMD0000000532) Modeling of chemical inhibition from amyloid prote [...] curated model icon download icon
Walsh2014 - Inhibition kinetics of DAPT on APP Cleavage (BIOMD0000000617) Are improper kinetic models hampering drug develop [...] curated model icon download icon
Winter2017 - Brain Energy Metabolism with PPP (BIOMD0000000627) Mathematical analysis of the influence of brain me [...] curated model icon download icon
Yuraszeck2010 - Vulnerabilities in the Tau Network in Tau Pathophysiology (BIOMD0000000542) Vulnerabilities in the tau network and the role of [...] curated model icon download icon

Those models are annotated with the term Alzheimer's disease from the Disease Ontology.

Huntington's disease

Model name Publication Status  
Clarke2000 - One-hit model of cell death in neuronal degenerations (BIOMD0000000538) A one-hit model of cell death in inherited neurona [...] curated model icon download icon
Morris2008 - Fitting protein aggregation data via F-W 2-step mechanism (BIOMD0000000567) Fitting neurological protein aggregation kinetic d [...] curated model icon download icon

Those models are annotated with the term Huntington's disease from the Disease Ontology.

Parkinson's disease

Model name Publication Status  
Auer2010 - Correlation between lag time and aggregation rate in protein aggregation (BIOMD0000000555) Insight into the correlation between lag time and [...] curated model icon download icon
Clarke2000 - One-hit model of cell death in neuronal degenerations (BIOMD0000000538) A one-hit model of cell death in inherited neurona [...] curated model icon download icon
Cloutier2012 - Feedback motif for Parkinson's disease (BIOMD0000000558) Feedback motif for the pathogenesis of Parkinson's [...] curated model icon download icon
Grange2001 - L Dopa PK model (BIOMD0000000321) A pharmacokinetic model to predict the PK interact [...] curated model icon download icon
Grange2001 - PK interaction of L-dopa and benserazide (BIOMD0000000320) A pharmacokinetic model to predict the PK interact [...] curated model icon download icon
Kuznetsov2016(II) - α-syn aggregation kinetics in Parkinson's Disease (BIOMD0000000615) What can trigger the onset of Parkinson's disease [...] curated model icon download icon
Martins2013 - True and apparent inhibition of amyloid fribril formation (BIOMD0000000561) True and apparent inhibition of amyloid fibril for [...] curated model icon download icon
Morris2008 - Fitting protein aggregation data via F-W 2-step mechanism (BIOMD0000000567) Fitting neurological protein aggregation kinetic d [...] curated model icon download icon
Morris2009 - α-Synuclein aggregation variable temperature and pH (BIOMD0000000566) Alpha-synuclein aggregation variable temperature a [...] curated model icon download icon
Ouzounoglou2014 - Modeling of alpha-synuclein effects on neuronal homeostasis (BIOMD0000000559) In silico modeling of the effects of alpha-synucle [...] curated model icon download icon
Proctor2005 - Actions of chaperones and their role in ageing (BIOMD0000000091) Modelling the actions of chaperones and their role [...] curated model icon download icon
Proctor2010 - UCHL1 Protein Aggregation (BIOMD0000000293) Modelling the role of UCH-L1 on protein aggregatio [...] curated model icon download icon
Reed2008_Glutathione_Metabolism (BIOMD0000000268) A mathematical model of glutathione metabolism. curated model icon download icon
Sass2009 - Approach to an α-synuclein-based BST model of Parkinson's disease (BIOMD0000000575) A pragmatic approach to biochemical systems theory [...] curated model icon download icon
Sneppen2009 - Modeling proteasome dynamics in Parkinson's disease (BIOMD0000000548) Modeling proteasome dynamics in Parkinson's diseas [...] curated model icon download icon

Those models are annotated with the term Parkinson's disease from the Disease Ontology.

amyotrophic lateral sclerosis

Model name Publication Status  
Wang2008_Rilusole_SkeletalMuscleCells (MODEL7817907010) Riluzole-induced block of voltage-gated Na+ curren [...] non-curated model icon download icon

This model is annotated with the term amyotrophic lateral sclerosis from the Disease Ontology.

neurodegenerative disease

Model name Publication Status  
Proctor2007 - Age related decline of proteolysis, ubiquitin-proteome system (BIOMD0000000105) An in silico model of the ubiquitin-proteasome sys [...] curated model icon download icon
Proctor2010 - UCHL1 Protein Aggregation (BIOMD0000000293) Modelling the role of UCH-L1 on protein aggregatio [...] curated model icon download icon
Proctor2011_ProteinHomeostasis_NormalCondition (BIOMD0000000344) Modelling the role of the Hsp70/Hsp90 system in th [...] curated model icon download icon
Tang2010_PolyGlutamate (BIOMD0000000285) Experimental and computational analysis of polyglu [...] curated model icon download icon

Those models are annotated with the term neurodegenerative disease from the Disease Ontology.

tauopathy

Model name Publication Status  
Yuraszeck2010 - Vulnerabilities in the Tau Network in Tau Pathophysiology (BIOMD0000000542) Vulnerabilities in the tau network and the role of [...] curated model icon download icon

This model is annotated with the term tauopathy from the Disease Ontology.

A review of mechanistic models on neurodegenerative disease processes was published in CPT:PSP.

AgedBrainSYSBIO logo EU logo

AgedBrainSYSBIO has received funding from the European Union's Seventh Framework Programme for research, technological development and demonstration under grant agreement No 305299

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