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Diseases related models

 

List of disease related literature based models (from the curated and non-curated branches).

Those models have been annotated with terms from the Human Disease Ontology, Online Mendelian Inheritance in Man or International Classification of Diseases.

Human Disease Ontology

Alzheimer's disease

Model name Publication Status  
Auer2010 - Correlation between lag time and aggregation rate in protein aggregation (BIOMD0000000555) Insight into the correlation between lag time and [...] curated model icon download icon
Crespo2012 - Kinetics of Amyloid Fibril Formation (BIOMD0000000531) A generic crystallization-like model that describe [...] curated model icon download icon
Das2010 - Effect of a gamma-secretase inhibitor on Amyloid-beta dynamics (BIOMD0000000551) Modeling effect of a γ-secretase inhibitor on amyl [...] curated model icon download icon
Ehrenstein1997 - The choline-leakage hypothesis in Alzheimer's disease (BIOMD0000000553) The choline-leakage hypothesis for the loss of ace [...] curated model icon download icon
Ehrenstein2000 - Positive-Feedback model for the loss of acetylcholine in Alzheimer's disease (BIOMD0000000552) A positive-feedback model for the loss of acetylch [...] curated model icon download icon
Krohn2011 - Cerebral amyloid-β proteostasis regulated by membrane transport protein ABCC1 (BIOMD0000000618) Cerebral amyloid-? proteostasis is regulated by th [...] curated model icon download icon
Lockwood2006_PKPD_AlzheimersDisease (MODEL1006230054) Application of clinical trial simulation to compar [...] non-curated model icon download icon
Martins2013 - True and apparent inhibition of amyloid fribril formation (BIOMD0000000561) True and apparent inhibition of amyloid fibril for [...] curated model icon download icon
Morris2008 - Fitting protein aggregation data via F-W 2-step mechanism (BIOMD0000000567) Fitting neurological protein aggregation kinetic d [...] curated model icon download icon
Ortega2013 - Interplay between secretases determines biphasic amyloid-beta level (BIOMD0000000556) Interplay between α-, β-, and γ-secretases determi [...] curated model icon download icon
Proctor2005 - Actions of chaperones and their role in ageing (BIOMD0000000091) Modelling the actions of chaperones and their role [...] curated model icon download icon
Proctor2010 - a link between GSK3 and p53 in Alzheimer's Disease (BIOMD0000000286) GSK3 and p53 - is there a link in Alzheimer's dise [...] curated model icon download icon
Proctor2012 - Role of Amyloid-beta dimers in aggregation formation (BIOMD0000000462) Aggregation, impaired degradation and immunization [...] curated model icon download icon
Proctor2013 - Effect of Aβ immunisation in Alzheimer's disease (deterministic version) (BIOMD0000000488) Investigating interventions in Alzheimer's disease [...] curated model icon download icon
Proctor2013 - Effect of Aβ immunisation in Alzheimer's disease (stochastic version) (BIOMD0000000634) Investigating interventions in Alzheimer's disease [...] curated model icon download icon
Reed2008_Glutathione_Metabolism (BIOMD0000000268) A mathematical model of glutathione metabolism. curated model icon download icon
Steckmann2012 - Amyloid beta-protein fibrillogenesis (kinetics of secondary structure conversion) (BIOMD0000000533) Kinetics of peptide secondary structure conversion [...] curated model icon download icon
Vazquez2014 - Chemical inhibition from amyloid protein aggregation kinetics (BIOMD0000000532) Modeling of chemical inhibition from amyloid prote [...] curated model icon download icon
Walsh2014 - Inhibition kinetics of DAPT on APP Cleavage (BIOMD0000000617) Are improper kinetic models hampering drug develop [...] curated model icon download icon
Winter2017 - Brain Energy Metabolism with PPP (BIOMD0000000627) Mathematical analysis of the influence of brain me [...] curated model icon download icon
Yuraszeck2010 - Vulnerabilities in the Tau Network in Tau Pathophysiology (BIOMD0000000542) Vulnerabilities in the tau network and the role of [...] curated model icon download icon

Andersen-Tawil syndrome

Model name Publication Status  
Clancy2001_Kchannel (BIOMD0000000121) Cellular consequences of HERG mutations in the lon [...] curated model icon download icon

Brugada syndrome

Model name Publication Status  
Clancy2002_CardiacSodiumChannel_WT (BIOMD0000000126) Na(+) channel mutation that causes both Brugada an [...] curated model icon download icon

Clostridium difficile colitis

Model name Publication Status  
Leber2015 - Mucosal immunity and gut microbiome interaction during C. difficile infection (BIOMD0000000583) Systems Modeling of Interactions between Mucosal I [...] curated model icon download icon

Crohn's disease

Model name Publication Status  
Dwivedi2014 - Crohns IL6 Disease model - Anti-IL6 Antibody (BIOMD0000000535) A multiscale model of interleukin-6-mediated immun [...] curated model icon download icon
Dwivedi2014 - Crohns IL6 Disease model - Anti-IL6R Antibody (BIOMD0000000537) A multiscale model of interleukin-6-mediated immun [...] curated model icon download icon
Dwivedi2014 - Crohns IL6 Disease model - sgp130 activity (BIOMD0000000536) A multiscale model of interleukin-6-mediated immun [...] curated model icon download icon
Dwivedi2014 - Healthy Volunteer IL6 Model (BIOMD0000000534) A multiscale model of interleukin-6-mediated immun [...] curated model icon download icon

Down syndrome

Model name Publication Status  
Kowald2006_SOD (BIOMD0000000108) Alternative pathways as mechanism for the negative [...] curated model icon download icon
Reed2008_Glutathione_Metabolism (BIOMD0000000268) A mathematical model of glutathione metabolism. curated model icon download icon

Helicobacter pylori infectious disease

Model name Publication Status  
Philipson2015 - Innate immune response modulated by NLRX1 (BIOMD0000000596) Modeling the Regulatory Mechanisms by Which NLRX1 [...] curated model icon download icon

Hodgkin's lymphoma

Model name Publication Status  
Raia2011 - IL13 L1236 (BIOMD0000000314) Dynamic mathematical modeling of IL13-induced sign [...] curated model icon download icon

Huntington's disease

Model name Publication Status  
Clarke2000 - One-hit model of cell death in neuronal degenerations (BIOMD0000000538) A one-hit model of cell death in inherited neurona [...] curated model icon download icon
Morris2008 - Fitting protein aggregation data via F-W 2-step mechanism (BIOMD0000000567) Fitting neurological protein aggregation kinetic d [...] curated model icon download icon

Paget's disease of bone

Model name Publication Status  
Komarova2003_BoneRemodeling (BIOMD0000000148) Mathematical model predicts a critical role for os [...] curated model icon download icon

Parkinson's disease

Model name Publication Status  
Auer2010 - Correlation between lag time and aggregation rate in protein aggregation (BIOMD0000000555) Insight into the correlation between lag time and [...] curated model icon download icon
Clarke2000 - One-hit model of cell death in neuronal degenerations (BIOMD0000000538) A one-hit model of cell death in inherited neurona [...] curated model icon download icon
Cloutier2012 - Feedback motif for Parkinson's disease (BIOMD0000000558) Feedback motif for the pathogenesis of Parkinson's [...] curated model icon download icon
Grange2001 - L Dopa PK model (BIOMD0000000321) A pharmacokinetic model to predict the PK interact [...] curated model icon download icon
Grange2001 - PK interaction of L-dopa and benserazide (BIOMD0000000320) A pharmacokinetic model to predict the PK interact [...] curated model icon download icon
Kuznetsov2016(II) - α-syn aggregation kinetics in Parkinson's Disease (BIOMD0000000615) What can trigger the onset of Parkinson's disease [...] curated model icon download icon
Martins2013 - True and apparent inhibition of amyloid fribril formation (BIOMD0000000561) True and apparent inhibition of amyloid fibril for [...] curated model icon download icon
Morris2008 - Fitting protein aggregation data via F-W 2-step mechanism (BIOMD0000000567) Fitting neurological protein aggregation kinetic d [...] curated model icon download icon
Morris2009 - α-Synuclein aggregation variable temperature and pH (BIOMD0000000566) Alpha-synuclein aggregation variable temperature a [...] curated model icon download icon
Ouzounoglou2014 - Modeling of alpha-synuclein effects on neuronal homeostasis (BIOMD0000000559) In silico modeling of the effects of alpha-synucle [...] curated model icon download icon
Proctor2005 - Actions of chaperones and their role in ageing (BIOMD0000000091) Modelling the actions of chaperones and their role [...] curated model icon download icon
Proctor2010 - UCHL1 Protein Aggregation (BIOMD0000000293) Modelling the role of UCH-L1 on protein aggregatio [...] curated model icon download icon
Reed2008_Glutathione_Metabolism (BIOMD0000000268) A mathematical model of glutathione metabolism. curated model icon download icon
Sass2009 - Approach to an α-synuclein-based BST model of Parkinson's disease (BIOMD0000000575) A pragmatic approach to biochemical systems theory [...] curated model icon download icon
Sneppen2009 - Modeling proteasome dynamics in Parkinson's disease (BIOMD0000000548) Modeling proteasome dynamics in Parkinson's diseas [...] curated model icon download icon

acute pancreatitis

Model name Publication Status  
Wollbold2014 - Effects of reactive oxygen species (MODEL1407230001) Anti-inflammatory effects of reactive oxygen speci [...] non-curated model icon download icon

amyloidosis

Model name Publication Status  
Ferreira2003_CML_generation2 (BIOMD0000000053) A quantitative model of the generation of N(epsilo [...] curated model icon download icon

amyotrophic lateral sclerosis

Model name Publication Status  
Wang2008_Rilusole_SkeletalMuscleCells (MODEL7817907010) Riluzole-induced block of voltage-gated Na+ curren [...] non-curated model icon download icon

asthma

Model name Publication Status  
Demin2013 - PKPD behaviour - 5-Lipoxygenase inhibitors (BIOMD0000000490) Systems pharmacology models can be used to underst [...] curated model icon download icon

autistic disorder

Model name Publication Status  
Reed2008_Glutathione_Metabolism (BIOMD0000000268) A mathematical model of glutathione metabolism. curated model icon download icon

bacterial infectious disease

Model name Publication Status  
Carbo2013 - Cytokine driven CD4+ T Cell differentiation and phenotype plasticity (BIOMD0000000451) Systems modeling of molecular mechanisms controlli [...] curated model icon download icon
Carbo2013 - Mucosal Immune Response during H.pylori Infection (BIOMD0000000480) Predictive computational modeling of the mucosal i [...] curated model icon download icon
Chan2004_TCell_receptor_activation (BIOMD0000000120) Feedback control of T-cell receptor activation. curated model icon download icon
Liu2011_Complement_System (BIOMD0000000303) A computational and experimental study of the regu [...] curated model icon download icon
Tan2012 - Antibiotic Treatment, Inoculum Effect (BIOMD0000000425) The inoculum effect and band-pass bacterial respon [...] curated model icon download icon

benign glioma

Model name Publication Status  
Ribba2012 - Low-grade gliomas, tumour growth inhibition model (BIOMD0000000521) A tumor growth inhibition model for low-grade glio [...] curated model icon download icon

blood coagulation disease

Model name Publication Status  
Nayak2015 - Blood Coagulation Network - Predicting the Effects of Various Therapies on Biomarkers (BIOMD0000000611) Using a Systems Pharmacology Model of the Blood Co [...] curated model icon download icon

botulism

Model name Publication Status  
Lebeda2008 - BoNT paralysis (3 step model) (BIOMD0000000267) Onset dynamics of type A botulinum neurotoxin-indu [...] curated model icon download icon
Lebeda2008 - BoTN Paralysis (4 step model) (BIOMD0000000178) Onset dynamics of type A botulinum neurotoxin-indu [...] curated model icon download icon

breast cancer

Model name Publication Status  
Morrison1989 - Folate Cycle (BIOMD0000000018) Folate cycle kinetics in human breast cancer cells [...] curated model icon download icon
Mufudza2012 - Estrogen effect on the dynamics of breast cancer (MODEL1304190001) Assessing the effects of estrogen on the dynamics [...] non-curated model icon download icon

calcium metabolism disease

Model name Publication Status  
Shrestha2010_HyperCalcemia_PTHresponse (BIOMD0000000277) A mathematical model of parathyroid hormone respon [...] curated model icon download icon
Shrestha2010_HypoCalcemia_PTHresponse (BIOMD0000000276) A mathematical model of parathyroid hormone respon [...] curated model icon download icon

cancer

Model name Publication Status  
Capuani2015 - Binding of Cbl and Gbr2 to EGFR (Multisite Phosphorylation Model - MPM) (BIOMD0000000594) Quantitative analysis reveals how EGFR activation [...] curated model icon download icon
Capuani2015 - Binding of Cbl and Grb2 to EGFR (Early Activation Model - EAM) (BIOMD0000000595) Quantitative analysis reveals how EGFR activation [...] curated model icon download icon
Faratian2009 - Role of PTEN in Trastuzumab resistance (BIOMD0000000424) Systems biology reveals new strategies for persona [...] curated model icon download icon
Mosca2012 - Central Carbon Metabolism Regulated by AKT (BIOMD0000000426) Computational modeling of the metabolic States reg [...] curated model icon download icon
Orton2009 - Modelling cancerous mutations in the EGFR/ERK pathway - EGF Model (BIOMD0000000623) Computational modelling of cancerous mutations in [...] curated model icon download icon
Reed2008_Glutathione_Metabolism (BIOMD0000000268) A mathematical model of glutathione metabolism. curated model icon download icon

cardiovascular system disease

Model name Publication Status  
Orfao2008_ThrombinGeneration_AmidolyticActivity (BIOMD0000000366) Qualitative properties and stabilizability of a mo [...] curated model icon download icon
Reed2008_Glutathione_Metabolism (BIOMD0000000268) A mathematical model of glutathione metabolism. curated model icon download icon

cartilage disease

Model name Publication Status  
Proctor2013 - Cartilage breakdown, interventions to reduce collagen release (BIOMD0000000504) A computer simulation approach for assessing thera [...] curated model icon download icon

cataract

Model name Publication Status  
Proctor2005 - Actions of chaperones and their role in ageing (BIOMD0000000091) Modelling the actions of chaperones and their role [...] curated model icon download icon

cerebral degeneration

Model name Publication Status  
Clarke2000 - One-hit model of cell death in neuronal degenerations (BIOMD0000000538) A one-hit model of cell death in inherited neurona [...] curated model icon download icon

cholesterol embolism

Model name Publication Status  
Bucher2011_Atorvastatin_Metabolism (BIOMD0000000328) A systems biology approach to dynamic modeling and [...] curated model icon download icon

cholesterol ester storage disease

Model name Publication Status  
McAuley2012 - Whole-body Cholesterol Metabolism (BIOMD0000000434) A whole-body mathematical model of cholesterol met [...] curated model icon download icon

colorectal cancer

Model name Publication Status  
Kim2007 - Crosstalk between Wnt and ERK pathways (BIOMD0000000149) A hidden oncogenic positive feedback loop caused b [...] curated model icon download icon

coronary artery disease

Model name Publication Status  
Mueller2008_ThrombinGeneration_minimal (BIOMD0000000367) Tolerance and threshold in the extrinsic coagulati [...] curated model icon download icon

diabetes mellitus

Model name Publication Status  
Alvehag2006_IVGTT_GlucoseModel_A (MODEL1112110000) The Feedback Control of Glucose: On the road to ty [...] non-curated model icon download icon
Alvehag2006_OGTT_GlucoseModel_B (MODEL1112110001) The Feedback Control of Glucose: On the road to ty [...] non-curated model icon download icon
Bertram2004_PancreaticBetaCell_modelB (BIOMD0000000373) Calcium and glycolysis mediate multiple bursting m [...] curated model icon download icon
Brannmark2010_InsulinSignalling_Mifamodel (BIOMD0000000343) Mass and information feedbacks through receptor en [...] curated model icon download icon
DallaMan2007_MealModel_GlucoseInsulinSystem (BIOMD0000000379) Meal simulation model of the glucose-insulin syste [...] curated model icon download icon
DeVries2000_PancreaticBetaCells_InsulinSecretion (BIOMD0000000371) Channel sharing in pancreatic beta -cells revisite [...] curated model icon download icon
Ferreira2003_CML_generation2 (BIOMD0000000053) A quantitative model of the generation of N(epsilo [...] curated model icon download icon
Fridlyand2010_GlucoseSensitivity_A (BIOMD0000000348) Glucose sensing in the pancreatic beta cell: a com [...] curated model icon download icon
Fridlyand2010_GlucoseSensitivity_B (BIOMD0000000349) Glucose sensing in the pancreatic beta cell: a com [...] curated model icon download icon
Jiang2007 - GSIS system, Pancreatic Beta Cells (BIOMD0000000239) A kinetic core model of the glucose-stimulated ins [...] curated model icon download icon
Koenig2012_HepaticGlucoseMetabolism (MODEL1209260000) Kinetic modeling of human hepatic glucose metaboli [...] non-curated model icon download icon
Koschorreck2008_InsulinClearance (BIOMD0000000345) Mathematical modeling and analysis of insulin clea [...] curated model icon download icon
Lenbury2001_InsulinKineticsModel_A (MODEL1201140002) Modeling insulin kinetics: responses to a single o [...] non-curated model icon download icon
Lenbury2001_InsulinKineticsModel_B (MODEL1201140003) Modeling insulin kinetics: responses to a single o [...] non-curated model icon download icon
Noguchi2013 - Insulin dependent glucose metabolism (BIOMD0000000482) The selective control of glycolysis, gluconeogenes [...] curated model icon download icon
Nyman2011_M3Hierarachical_InsulinGlucosedynamics (BIOMD0000000356) A hierarchical whole-body modeling approach elucid [...] curated model icon download icon
Sedaghat2002_InsulinSignalling_noFeedback (BIOMD0000000137) A mathematical model of metabolic insulin signalin [...] curated model icon download icon
Smith2013 - Regulation of Insulin Signalling by Oxidative Stress (BIOMD0000000474) Computational modelling of the regulation of Insul [...] curated model icon download icon
Sturis1991_InsulinGlucoseModel_UltradianOscillation (BIOMD0000000382) Computer model for mechanisms underlying ultradian [...] curated model icon download icon
Tolic2000_InsulinGlucoseFeedback (BIOMD0000000372) Modeling the insulin-glucose feedback system: the [...] curated model icon download icon
Topp2000_BetaCellMass_Diabetes (BIOMD0000000341) A model of beta-cell mass, insulin, and glucose ki [...] curated model icon download icon

disease by infectious agent

Model name Publication Status  
Munz2009 - Zombi Impulsive Killing (MODEL1008060000) When Zombies Attack!: Mathematical modelling of an [...] non-curated model icon download icon
Munz2009 - Zombie SIZRC (MODEL1008060001) When Zombies Attack!: Mathematical modelling of an [...] non-curated model icon download icon
Munz2009 - Zombie SIZRQ (MODEL1008060002) When Zombies Attack!: Mathematical modelling of an [...] non-curated model icon download icon
Munz2009 - Zombie basic SZR (MODEL1009230000) When Zombies Attack!: Mathematical modelling of an [...] non-curated model icon download icon

duodenal ulcer

Model name Publication Status  
Leber2016 - Expanded model of Tfh-Tfr differentiation - Helicobacter pylori infection (BIOMD0000000625) Bistability analyses of CD4+ T follicular helper a [...] curated model icon download icon

fatty liver disease

Model name Publication Status  
Tiemann2011_PhenotypeTransitions (MODEL1112150000) Parameter adaptations during phenotype transitions [...] non-curated model icon download icon

glucocorticoid-remediable aldosteronism

Model name Publication Status  
Komarova2005_PTHaction_OsteoclastOsteoblastCoupling (BIOMD0000000279) Mathematical model of paracrine interactions betwe [...] curated model icon download icon
Lemaire2004 - Role of RANK/RANKL/OPG pathway in bone remodelling process (BIOMD0000000278) Modeling the interactions between osteoblast and o [...] curated model icon download icon

heart disease

Model name Publication Status  
Bucher2011_Atorvastatin_Metabolism (BIOMD0000000328) A systems biology approach to dynamic modeling and [...] curated model icon download icon
Saucerman2006_PKA (BIOMD0000000165) Systems analysis of PKA-mediated phosphorylation g [...] curated model icon download icon
Wang2008_Neonatal_heartfunction (MODEL7814665196) Mathematical model of the neonatal mouse ventricul [...] non-curated model icon download icon

hemochromatosis

Model name Publication Status  
Mitchell2013 - Liver Iron Metabolism (BIOMD0000000498) A computational model of liver iron metabolism. curated model icon download icon

hemophilia B

Model name Publication Status  
Wajima2009_BloodCoagulation_PTtest (BIOMD0000000339) A comprehensive model for the humoral coagulation [...] curated model icon download icon
Wajima2009_BloodCoagulation_aPTTtest (BIOMD0000000338) A comprehensive model for the humoral coagulation [...] curated model icon download icon
Wajima2009_BloodCoagulation_warfarin_heparin (BIOMD0000000340) A comprehensive model for the humoral coagulation [...] curated model icon download icon

human immunodeficiency virus infectious disease

Model name Publication Status  
Aguilera 2014 - HIV latency. Interaction between HIV proteins and immune response (BIOMD0000000573) Studying HIV latency by modeling the interaction b [...] curated model icon download icon
Nelson2000_HIV-1_general_model (MODEL8268650277) A model of HIV-1 pathogenesis that includes an int [...] non-curated model icon download icon
Nelson2000_HIV-1_intracellular_delay (MODEL8102792069) A model of HIV-1 pathogenesis that includes an int [...] non-curated model icon download icon

hyperparathyroidism

Model name Publication Status  
Peterson2010 - Integrated calcium homeostasis and bone remodelling (BIOMD0000000613) A physiologically based mathematical model of inte [...] curated model icon download icon

hypersensitivity reaction type II disease

Model name Publication Status  
Alexander2010_Tcell_Regulation_Sys1 (BIOMD0000000289) Self-tolerance and autoimmunity in a regulatory T [...] curated model icon download icon
Alexander2010_Tcell_Regulation_Sys2 (BIOMD0000000290) Self-tolerance and autoimmunity in a regulatory T [...] curated model icon download icon

hypoparathyroidism

Model name Publication Status  
Peterson2010 - Integrated calcium homeostasis and bone remodelling (BIOMD0000000613) A physiologically based mathematical model of inte [...] curated model icon download icon

immune system disease

Model name Publication Status  
Dunster2014 - WBC Interactions (Model1) (BIOMD0000000616) The resolution of inflammation: a mathematical mod [...] curated model icon download icon

influenza

Model name Publication Status  
Fribourg2014 - Dynamics of viral antagonism and innate immune response (H1N1 influenza A virus - NC/99) (BIOMD0000000529) Model of influenza A virus infection: dynamics of [...] curated model icon download icon
Heldt2012 - Influenza Virus Replication (BIOMD0000000463) Modeling the intracellular dynamics of influenza v [...] curated model icon download icon
Miao2010 - Innate and adaptive immune responses to primary Influenza A Virus infection (BIOMD0000000546) Quantifying the early immune response and adaptive [...] curated model icon download icon

inherited blood coagulation disease

Model name Publication Status  
Hockin1999_BloodCoagulation_VaInactivation (BIOMD0000000365) A model describing the inactivation of factor Va b [...] curated model icon download icon

leishmaniasis

Model name Publication Status  
Mandlik2013 - Synthetic circuit of IPC synthase in Leishmania (MODEL1208030000) Synthetic circuit of inositol phosphorylceramide s [...] non-curated model icon download icon
Mandlik2015 - Tristable genetic circuit of Leishmania (BIOMD0000000584) Regulatory dynamics of network architecture and fu [...] curated model icon download icon
Mol2013 - Immune Signal Transduction in Leishmaniasis (BIOMD0000000477) Immune signal transduction in leishmaniasis from n [...] curated model icon download icon
Mol2013 - Leishmania macrophage signaling network (MODEL1203220000) Signaling networks in Leishmania macrophages decip [...] non-curated model icon download icon

liver disease

Model name Publication Status  
Mueller2015 - Hepatocyte proliferation, T160 phosphorylation of CDK2 (BIOMD0000000568) T160-phosphorylated CDK2 defines threshold for HGF [...] curated model icon download icon
Nikolaev2005_AlbuminBilirubinAdsorption (BIOMD0000000291) Mathematical model of binding of albumin-bilirubin [...] curated model icon download icon

lung cancer

Model name Publication Status  
Tham2008 - PDmodel, Tumour shrinkage by gemcitabine and carboplatin (BIOMD0000000234) A pharmacodynamic model for the time course of tum [...] curated model icon download icon

mature T-cell and NK-cell lymphoma

Model name Publication Status  
Raia2010 - IL13 Signalling MedB1 (BIOMD0000000313) Dynamic mathematical modeling of IL13-induced sign [...] curated model icon download icon

multiple myeloma

Model name Publication Status  
Ayati2010_BoneRemodelingDynamics_NormalCondition (BIOMD0000000401) A mathematical model of bone remodeling dynamics f [...] curated model icon download icon
Ayati2010_BoneRemodelingDynamics_WithTumour (BIOMD0000000402) A mathematical model of bone remodeling dynamics f [...] curated model icon download icon
Ayati2010_BoneRemodelingDynamics_WithTumour+DrugTreatment (BIOMD0000000403) A mathematical model of bone remodeling dynamics f [...] curated model icon download icon

neonatal abstinence syndrome

Model name Publication Status  
Yang2006_Methadone_PKmodel (MODEL1006230040) Population-based analysis of methadone distributio [...] non-curated model icon download icon

neurodegenerative disease

Model name Publication Status  
Proctor2007 - Age related decline of proteolysis, ubiquitin-proteome system (BIOMD0000000105) An in silico model of the ubiquitin-proteasome sys [...] curated model icon download icon
Proctor2010 - UCHL1 Protein Aggregation (BIOMD0000000293) Modelling the role of UCH-L1 on protein aggregatio [...] curated model icon download icon
Proctor2011_ProteinHomeostasis_NormalCondition (BIOMD0000000344) Modelling the role of the Hsp70/Hsp90 system in th [...] curated model icon download icon
Tang2010_PolyGlutamate (BIOMD0000000285) Experimental and computational analysis of polyglu [...] curated model icon download icon

non-small cell lung carcinoma

Model name Publication Status  
Bianconi2012 - EGFR and IGF1R pathway in lung cancer (BIOMD0000000427) Computational model of EGFR and IGF1R pathways in [...] curated model icon download icon
Bidkhori2012 - EGFR signalling in NSCLC (BIOMD0000000453) Modeling of tumor progression in NSCLC and intrins [...] curated model icon download icon

ocular albinism

Model name Publication Status  
Clarke2000 - One-hit model of cell death in neuronal degenerations (BIOMD0000000538) A one-hit model of cell death in inherited neurona [...] curated model icon download icon

osteoarthritis

Model name Publication Status  
Benson2014 - FAAH inhibitors for the treatment of osteoarthritic pain (BIOMD0000000512) A systems pharmacology perspective on the clinical [...] curated model icon download icon
Hui2014 - Age-related changes in articular cartilage (BIOMD0000000560) Oxidative changes and signalling pathways are pivo [...] curated model icon download icon
Komarova2003_BoneRemodeling (BIOMD0000000148) Mathematical model predicts a critical role for os [...] curated model icon download icon

osteoporosis

Model name Publication Status  
Komarova2003_BoneRemodeling (BIOMD0000000148) Mathematical model predicts a critical role for os [...] curated model icon download icon

ovarian disease

Model name Publication Status  
Roblitz2013 - Menstrual Cycle following GnRH analogue administration (BIOMD0000000494) A mathematical model of the human menstrual cycle [...] curated model icon download icon
Stötzel2012 - Bovine estrous cycle, synchronization with prostaglandin F2α (BIOMD0000000481) Advances in modeling of the bovine estrous cycle: [...] curated model icon download icon

pancreatic cancer

Model name Publication Status  
Rateitschak2012 - Interferon-gamma (IFN?) induced STAT1 signalling (PC_IFNg100) (BIOMD0000000585) Parameter identifiability and sensitivity analysis [...] curated model icon download icon

peptic ulcer disease

Model name Publication Status  
Leber2016 - Expanded model of Tfh-Tfr differentiation - Helicobacter pylori infection (BIOMD0000000625) Bistability analyses of CD4+ T follicular helper a [...] curated model icon download icon

pertussis

Model name Publication Status  
Restif2006 - Whooping cough (BIOMD0000000249) Integrating life history and cross-immunity into t [...] curated model icon download icon
Restif2007 - Vaccination invasion (BIOMD0000000294) Vaccination and the dynamics of immune evasion. curated model icon download icon

polycythemia due to hypoxia

Model name Publication Status  
Hunziker2010_p53_StressSpecificResponse (BIOMD0000000252) Stress-specific response of the p53-Mdm2 feedback [...] curated model icon download icon
Schmierer2010_FIH_Ankyrins (BIOMD0000000300) Hypoxia-dependent sequestration of an oxygen senso [...] curated model icon download icon

primary bacterial infectious disease

Model name Publication Status  
Kaiser2014 - Salmonella persistence after ciprofloxacin treatment (BIOMD0000000527) Cecum lymph node dendritic cells harbor slow-growi [...] curated model icon download icon

prion disease

Model name Publication Status  
Martins2013 - True and apparent inhibition of amyloid fribril formation (BIOMD0000000561) True and apparent inhibition of amyloid fibril for [...] curated model icon download icon

retinal degeneration

Model name Publication Status  
Clarke2000 - One-hit model of cell death in neuronal degenerations (BIOMD0000000538) A one-hit model of cell death in inherited neurona [...] curated model icon download icon

retinal detachment

Model name Publication Status  
Clarke2000 - One-hit model of cell death in neuronal degenerations (BIOMD0000000538) A one-hit model of cell death in inherited neurona [...] curated model icon download icon

retinal disease

Model name Publication Status  
Clarke2000 - One-hit model of cell death in neuronal degenerations (BIOMD0000000538) A one-hit model of cell death in inherited neurona [...] curated model icon download icon

rheumatoid arthritis

Model name Publication Status  
Baker2013 - Cytokine Mediated Inflammation in Rheumatoid Arthritis (BIOMD0000000550) Mathematical modelling of cytokine-mediated inflam [...] curated model icon download icon
Baker2013 - Cytokine Mediated Inflammation in Rheumatoid Arthritis - Age Dependent (BIOMD0000000549) Mathematical modelling of cytokine-mediated inflam [...] curated model icon download icon

swine influenza

Model name Publication Status  
Fribourg2014 - Dynamics of viral antagonism and innate immune response (H1N1 influenza A virus - Cal/09) (BIOMD0000000528) Model of influenza A virus infection: dynamics of [...] curated model icon download icon

tauopathy

Model name Publication Status  
Yuraszeck2010 - Vulnerabilities in the Tau Network in Tau Pathophysiology (BIOMD0000000542) Vulnerabilities in the tau network and the role of [...] curated model icon download icon

tuberculosis

Model name Publication Status  
Palsson2013 - Fully-integrated immune response model (FIRM) (BIOMD0000000608) The development of a fully-integrated immune respo [...] curated model icon download icon

type 1 diabetes mellitus

Model name Publication Status  
Maree2006_DuCa_Type1DiabetesModel (BIOMD0000000381) Modelling the onset of Type 1 diabetes: can impair [...] curated model icon download icon

type 2 diabetes mellitus

Model name Publication Status  
Brännmark2013 - Insulin signalling in human adipocytes (diabetic condition) (BIOMD0000000449) Insulin signaling in type 2 diabetes: experimental [...] curated model icon download icon
Brännmark2013 - Insulin signalling in human adipocytes (normal condition) (BIOMD0000000448) Insulin signaling in type 2 diabetes: experimental [...] curated model icon download icon
Palmer2014 - Effect of IL-1β-Blocking therapies in T2DM - Disease Condition (BIOMD0000000620) Effects of IL-1β-Blocking Therapies in Type 2 Diab [...] curated model icon download icon
Palmer2014 - Effect of IL-1β-Blocking therapies in T2DM - Healthy Condition (BIOMD0000000621) Effects of IL-1β-Blocking Therapies in Type 2 Diab [...] curated model icon download icon
Silber2007_IntravenousGlucose_IntegratedGlucoseInsulinModel (MODEL1112110004) An integrated model for glucose and insulin regula [...] non-curated model icon download icon

See also: Human Disease Ontology.

Online Mendelian Inheritance in Man

BH3-INTERACTING DOMAIN DEATH AGONIST; BID

Model name Publication Status  
Albeck2008_extrinsic_apoptosis (BIOMD0000000220) Quantitative analysis of pathways controlling extr [...] curated model icon download icon

BRUGADA SYNDROME 1; BRGDA1

Model name Publication Status  
Clancy2002_CardiacSodiumChannel_WT (BIOMD0000000126) Na(+) channel mutation that causes both Brugada an [...] curated model icon download icon

CASP8- AND FADD-LIKE APOPTOSIS REGULATOR; CFLAR

Model name Publication Status  
Albeck2008_extrinsic_apoptosis (BIOMD0000000220) Quantitative analysis of pathways controlling extr [...] curated model icon download icon

DUAL-SPECIFICITY PHOSPHATASE 1; DUSP1

Model name Publication Status  
Birtwistle2007_ErbB_Signalling (BIOMD0000000175) Ligand-dependent responses of the ErbB signaling n [...] curated model icon download icon

DUAL-SPECIFICITY PHOSPHATASE 4; DUSP4

Model name Publication Status  
Birtwistle2007_ErbB_Signalling (BIOMD0000000175) Ligand-dependent responses of the ErbB signaling n [...] curated model icon download icon

DUAL-SPECIFICITY PHOSPHATASE 6; DUSP6

Model name Publication Status  
Birtwistle2007_ErbB_Signalling (BIOMD0000000175) Ligand-dependent responses of the ErbB signaling n [...] curated model icon download icon

EPIDERMAL GROWTH FACTOR; EGF

Model name Publication Status  
Birtwistle2007_ErbB_Signalling (BIOMD0000000175) Ligand-dependent responses of the ErbB signaling n [...] curated model icon download icon

GRB2-ASSOCIATED BINDING PROTEIN 1; GAB1

Model name Publication Status  
Birtwistle2007_ErbB_Signalling (BIOMD0000000175) Ligand-dependent responses of the ErbB signaling n [...] curated model icon download icon

GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2; GRB2

Model name Publication Status  
Birtwistle2007_ErbB_Signalling (BIOMD0000000175) Ligand-dependent responses of the ErbB signaling n [...] curated model icon download icon
Chen2009 - ErbB Signaling (BIOMD0000000255) Input-output behavior of ErbB signaling pathways a [...] curated model icon download icon
Jenkinson2011_EGF_MAPK (BIOMD0000000399) Thermodynamically consistent model calibration in [...] curated model icon download icon
Schoeberl2002 - EGF MAPK (BIOMD0000000019) Computational modeling of the dynamics of the MAP [...] curated model icon download icon

HAIRY/ENHANCER OF SPLIT, DROSOPHILA, HOMOLOG OF, 1; HES1

Model name Publication Status  
Sivakumar2011_NeuralStemCellDifferentiation_Crosstalk (BIOMD0000000398) A systems biology approach to model neural stem ce [...] curated model icon download icon

INTERLEUKIN 21; IL21

Model name Publication Status  
Overgaard2007_PDmodel_IL21 (BIOMD0000000238) PKPD model of interleukin-21 effects on thermoregu [...] curated model icon download icon

LONG QT SYNDROME 3; LQT3

Model name Publication Status  
Clancy2002_CardiacSodiumChannel_WT (BIOMD0000000126) Na(+) channel mutation that causes both Brugada an [...] curated model icon download icon

MITOGEN-ACTIVATED PROTEIN KINASE 1; MAPK1

Model name Publication Status  
Birtwistle2007_ErbB_Signalling (BIOMD0000000175) Ligand-dependent responses of the ErbB signaling n [...] curated model icon download icon
Chen2009 - ErbB Signaling (BIOMD0000000255) Input-output behavior of ErbB signaling pathways a [...] curated model icon download icon
Jenkinson2011_EGF_MAPK (BIOMD0000000399) Thermodynamically consistent model calibration in [...] curated model icon download icon
Schoeberl2002 - EGF MAPK (BIOMD0000000019) Computational modeling of the dynamics of the MAP [...] curated model icon download icon

MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1; MAP2K1

Model name Publication Status  
Birtwistle2007_ErbB_Signalling (BIOMD0000000175) Ligand-dependent responses of the ErbB signaling n [...] curated model icon download icon
Chen2009 - ErbB Signaling (BIOMD0000000255) Input-output behavior of ErbB signaling pathways a [...] curated model icon download icon
Jenkinson2011_EGF_MAPK (BIOMD0000000399) Thermodynamically consistent model calibration in [...] curated model icon download icon
Schoeberl2002 - EGF MAPK (BIOMD0000000019) Computational modeling of the dynamics of the MAP [...] curated model icon download icon

NEUREGULIN 1; NRG1

Model name Publication Status  
Birtwistle2007_ErbB_Signalling (BIOMD0000000175) Ligand-dependent responses of the ErbB signaling n [...] curated model icon download icon

NITRIC OXIDE SYNTHASE 1; NOS1

Model name Publication Status  
Santolini2001_nNOS_Mechanism_Regulation (BIOMD0000000199) A kinetic simulation model that describes catalysi [...] curated model icon download icon

POTASSIUM CHANNEL, VOLTAGE-GATED, SUBFAMILY H, MEMBER 2; KCNH2

Model name Publication Status  
Clancy2001_Kchannel (BIOMD0000000121) Cellular consequences of HERG mutations in the lon [...] curated model icon download icon

PROTEIN-TYROSINE PHOSPHATASE, NONRECEPTOR-TYPE, 1; PTPN1

Model name Publication Status  
Birtwistle2007_ErbB_Signalling (BIOMD0000000175) Ligand-dependent responses of the ErbB signaling n [...] curated model icon download icon

RAS p21 PROTEIN ACTIVATOR 1; RASA1

Model name Publication Status  
Birtwistle2007_ErbB_Signalling (BIOMD0000000175) Ligand-dependent responses of the ErbB signaling n [...] curated model icon download icon
Chen2009 - ErbB Signaling (BIOMD0000000255) Input-output behavior of ErbB signaling pathways a [...] curated model icon download icon
Jenkinson2011_EGF_MAPK (BIOMD0000000399) Thermodynamically consistent model calibration in [...] curated model icon download icon
Schoeberl2002 - EGF MAPK (BIOMD0000000019) Computational modeling of the dynamics of the MAP [...] curated model icon download icon

SHC TRANSFORMING PROTEIN 2; SHC2

Model name Publication Status  
Birtwistle2007_ErbB_Signalling (BIOMD0000000175) Ligand-dependent responses of the ErbB signaling n [...] curated model icon download icon
Chen2009 - ErbB Signaling (BIOMD0000000255) Input-output behavior of ErbB signaling pathways a [...] curated model icon download icon
Jenkinson2011_EGF_MAPK (BIOMD0000000399) Thermodynamically consistent model calibration in [...] curated model icon download icon
Schoeberl2002 - EGF MAPK (BIOMD0000000019) Computational modeling of the dynamics of the MAP [...] curated model icon download icon

SON OF SEVENLESS, DROSOPHILA, HOMOLOG 1; SOS1

Model name Publication Status  
Birtwistle2007_ErbB_Signalling (BIOMD0000000175) Ligand-dependent responses of the ErbB signaling n [...] curated model icon download icon
Chen2009 - ErbB Signaling (BIOMD0000000255) Input-output behavior of ErbB signaling pathways a [...] curated model icon download icon
Jenkinson2011_EGF_MAPK (BIOMD0000000399) Thermodynamically consistent model calibration in [...] curated model icon download icon
Schoeberl2002 - EGF MAPK (BIOMD0000000019) Computational modeling of the dynamics of the MAP [...] curated model icon download icon

V-AKT MURINE THYMOMA VIRAL ONCOGENE HOMOLOG 3; AKT3

Model name Publication Status  
Birtwistle2007_ErbB_Signalling (BIOMD0000000175) Ligand-dependent responses of the ErbB signaling n [...] curated model icon download icon

V-RAF-1 MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1; RAF1

Model name Publication Status  
Chen2009 - ErbB Signaling (BIOMD0000000255) Input-output behavior of ErbB signaling pathways a [...] curated model icon download icon
Schoeberl2002 - EGF MAPK (BIOMD0000000019) Computational modeling of the dynamics of the MAP [...] curated model icon download icon

See also: Online Mendelian Inheritance in Man

International Classification of Diseases

Alzheimer's disease

Model name Publication Status  
Auer2010 - Correlation between lag time and aggregation rate in protein aggregation (BIOMD0000000555) Insight into the correlation between lag time and [...] curated model icon download icon
Crespo2012 - Kinetics of Amyloid Fibril Formation (BIOMD0000000531) A generic crystallization-like model that describe [...] curated model icon download icon
Das2010 - Effect of a gamma-secretase inhibitor on Amyloid-beta dynamics (BIOMD0000000551) Modeling effect of a γ-secretase inhibitor on amyl [...] curated model icon download icon
Ehrenstein1997 - The choline-leakage hypothesis in Alzheimer's disease (BIOMD0000000553) The choline-leakage hypothesis for the loss of ace [...] curated model icon download icon
Ehrenstein2000 - Positive-Feedback model for the loss of acetylcholine in Alzheimer's disease (BIOMD0000000552) A positive-feedback model for the loss of acetylch [...] curated model icon download icon
Krohn2011 - Cerebral amyloid-β proteostasis regulated by membrane transport protein ABCC1 (BIOMD0000000618) Cerebral amyloid-? proteostasis is regulated by th [...] curated model icon download icon
Lockwood2006_PKPD_AlzheimersDisease (MODEL1006230054) Application of clinical trial simulation to compar [...] non-curated model icon download icon
Martins2013 - True and apparent inhibition of amyloid fribril formation (BIOMD0000000561) True and apparent inhibition of amyloid fibril for [...] curated model icon download icon
Morris2008 - Fitting protein aggregation data via F-W 2-step mechanism (BIOMD0000000567) Fitting neurological protein aggregation kinetic d [...] curated model icon download icon
Ortega2013 - Interplay between secretases determines biphasic amyloid-beta level (BIOMD0000000556) Interplay between α-, β-, and γ-secretases determi [...] curated model icon download icon
Proctor2005 - Actions of chaperones and their role in ageing (BIOMD0000000091) Modelling the actions of chaperones and their role [...] curated model icon download icon
Proctor2010 - a link between GSK3 and p53 in Alzheimer's Disease (BIOMD0000000286) GSK3 and p53 - is there a link in Alzheimer's dise [...] curated model icon download icon
Proctor2012 - Role of Amyloid-beta dimers in aggregation formation (BIOMD0000000462) Aggregation, impaired degradation and immunization [...] curated model icon download icon
Proctor2013 - Effect of Aβ immunisation in Alzheimer's disease (deterministic version) (BIOMD0000000488) Investigating interventions in Alzheimer's disease [...] curated model icon download icon
Proctor2013 - Effect of Aβ immunisation in Alzheimer's disease (stochastic version) (BIOMD0000000634) Investigating interventions in Alzheimer's disease [...] curated model icon download icon
Reed2008_Glutathione_Metabolism (BIOMD0000000268) A mathematical model of glutathione metabolism. curated model icon download icon
Steckmann2012 - Amyloid beta-protein fibrillogenesis (kinetics of secondary structure conversion) (BIOMD0000000533) Kinetics of peptide secondary structure conversion [...] curated model icon download icon
Vazquez2014 - Chemical inhibition from amyloid protein aggregation kinetics (BIOMD0000000532) Modeling of chemical inhibition from amyloid prote [...] curated model icon download icon
Walsh2014 - Inhibition kinetics of DAPT on APP Cleavage (BIOMD0000000617) Are improper kinetic models hampering drug develop [...] curated model icon download icon
Winter2017 - Brain Energy Metabolism with PPP (BIOMD0000000627) Mathematical analysis of the influence of brain me [...] curated model icon download icon
Yuraszeck2010 - Vulnerabilities in the Tau Network in Tau Pathophysiology (BIOMD0000000542) Vulnerabilities in the tau network and the role of [...] curated model icon download icon

Andersen-Tawil syndrome

Model name Publication Status  
Clancy2001_Kchannel (BIOMD0000000121) Cellular consequences of HERG mutations in the lon [...] curated model icon download icon

Brugada syndrome

Model name Publication Status  
Clancy2002_CardiacSodiumChannel_WT (BIOMD0000000126) Na(+) channel mutation that causes both Brugada an [...] curated model icon download icon

Clostridium difficile colitis

Model name Publication Status  
Leber2015 - Mucosal immunity and gut microbiome interaction during C. difficile infection (BIOMD0000000583) Systems Modeling of Interactions between Mucosal I [...] curated model icon download icon

Crohn's disease

Model name Publication Status  
Dwivedi2014 - Crohns IL6 Disease model - Anti-IL6 Antibody (BIOMD0000000535) A multiscale model of interleukin-6-mediated immun [...] curated model icon download icon
Dwivedi2014 - Crohns IL6 Disease model - Anti-IL6R Antibody (BIOMD0000000537) A multiscale model of interleukin-6-mediated immun [...] curated model icon download icon
Dwivedi2014 - Crohns IL6 Disease model - sgp130 activity (BIOMD0000000536) A multiscale model of interleukin-6-mediated immun [...] curated model icon download icon
Dwivedi2014 - Healthy Volunteer IL6 Model (BIOMD0000000534) A multiscale model of interleukin-6-mediated immun [...] curated model icon download icon

Down syndrome

Model name Publication Status  
Kowald2006_SOD (BIOMD0000000108) Alternative pathways as mechanism for the negative [...] curated model icon download icon
Reed2008_Glutathione_Metabolism (BIOMD0000000268) A mathematical model of glutathione metabolism. curated model icon download icon

Helicobacter pylori infectious disease

Model name Publication Status  
Philipson2015 - Innate immune response modulated by NLRX1 (BIOMD0000000596) Modeling the Regulatory Mechanisms by Which NLRX1 [...] curated model icon download icon

Hodgkin's lymphoma

Model name Publication Status  
Raia2011 - IL13 L1236 (BIOMD0000000314) Dynamic mathematical modeling of IL13-induced sign [...] curated model icon download icon

Huntington's disease

Model name Publication Status  
Clarke2000 - One-hit model of cell death in neuronal degenerations (BIOMD0000000538) A one-hit model of cell death in inherited neurona [...] curated model icon download icon
Morris2008 - Fitting protein aggregation data via F-W 2-step mechanism (BIOMD0000000567) Fitting neurological protein aggregation kinetic d [...] curated model icon download icon

Paget's disease of bone

Model name Publication Status  
Komarova2003_BoneRemodeling (BIOMD0000000148) Mathematical model predicts a critical role for os [...] curated model icon download icon

Parkinson's disease

Model name Publication Status  
Auer2010 - Correlation between lag time and aggregation rate in protein aggregation (BIOMD0000000555) Insight into the correlation between lag time and [...] curated model icon download icon
Clarke2000 - One-hit model of cell death in neuronal degenerations (BIOMD0000000538) A one-hit model of cell death in inherited neurona [...] curated model icon download icon
Cloutier2012 - Feedback motif for Parkinson's disease (BIOMD0000000558) Feedback motif for the pathogenesis of Parkinson's [...] curated model icon download icon
Grange2001 - L Dopa PK model (BIOMD0000000321) A pharmacokinetic model to predict the PK interact [...] curated model icon download icon
Grange2001 - PK interaction of L-dopa and benserazide (BIOMD0000000320) A pharmacokinetic model to predict the PK interact [...] curated model icon download icon
Kuznetsov2016(II) - α-syn aggregation kinetics in Parkinson's Disease (BIOMD0000000615) What can trigger the onset of Parkinson's disease [...] curated model icon download icon
Martins2013 - True and apparent inhibition of amyloid fribril formation (BIOMD0000000561) True and apparent inhibition of amyloid fibril for [...] curated model icon download icon
Morris2008 - Fitting protein aggregation data via F-W 2-step mechanism (BIOMD0000000567) Fitting neurological protein aggregation kinetic d [...] curated model icon download icon
Morris2009 - α-Synuclein aggregation variable temperature and pH (BIOMD0000000566) Alpha-synuclein aggregation variable temperature a [...] curated model icon download icon
Ouzounoglou2014 - Modeling of alpha-synuclein effects on neuronal homeostasis (BIOMD0000000559) In silico modeling of the effects of alpha-synucle [...] curated model icon download icon
Proctor2005 - Actions of chaperones and their role in ageing (BIOMD0000000091) Modelling the actions of chaperones and their role [...] curated model icon download icon
Proctor2010 - UCHL1 Protein Aggregation (BIOMD0000000293) Modelling the role of UCH-L1 on protein aggregatio [...] curated model icon download icon
Reed2008_Glutathione_Metabolism (BIOMD0000000268) A mathematical model of glutathione metabolism. curated model icon download icon
Sass2009 - Approach to an α-synuclein-based BST model of Parkinson's disease (BIOMD0000000575) A pragmatic approach to biochemical systems theory [...] curated model icon download icon
Sneppen2009 - Modeling proteasome dynamics in Parkinson's disease (BIOMD0000000548) Modeling proteasome dynamics in Parkinson's diseas [...] curated model icon download icon

acute pancreatitis

Model name Publication Status  
Wollbold2014 - Effects of reactive oxygen species (MODEL1407230001) Anti-inflammatory effects of reactive oxygen speci [...] non-curated model icon download icon

amyloidosis

Model name Publication Status  
Ferreira2003_CML_generation2 (BIOMD0000000053) A quantitative model of the generation of N(epsilo [...] curated model icon download icon

amyotrophic lateral sclerosis

Model name Publication Status  
Wang2008_Rilusole_SkeletalMuscleCells (MODEL7817907010) Riluzole-induced block of voltage-gated Na+ curren [...] non-curated model icon download icon

asthma

Model name Publication Status  
Demin2013 - PKPD behaviour - 5-Lipoxygenase inhibitors (BIOMD0000000490) Systems pharmacology models can be used to underst [...] curated model icon download icon

autistic disorder

Model name Publication Status  
Reed2008_Glutathione_Metabolism (BIOMD0000000268) A mathematical model of glutathione metabolism. curated model icon download icon

bacterial infectious disease

Model name Publication Status  
Carbo2013 - Cytokine driven CD4+ T Cell differentiation and phenotype plasticity (BIOMD0000000451) Systems modeling of molecular mechanisms controlli [...] curated model icon download icon
Carbo2013 - Mucosal Immune Response during H.pylori Infection (BIOMD0000000480) Predictive computational modeling of the mucosal i [...] curated model icon download icon
Chan2004_TCell_receptor_activation (BIOMD0000000120) Feedback control of T-cell receptor activation. curated model icon download icon
Liu2011_Complement_System (BIOMD0000000303) A computational and experimental study of the regu [...] curated model icon download icon
Tan2012 - Antibiotic Treatment, Inoculum Effect (BIOMD0000000425) The inoculum effect and band-pass bacterial respon [...] curated model icon download icon

benign glioma

Model name Publication Status  
Ribba2012 - Low-grade gliomas, tumour growth inhibition model (BIOMD0000000521) A tumor growth inhibition model for low-grade glio [...] curated model icon download icon

blood coagulation disease

Model name Publication Status  
Nayak2015 - Blood Coagulation Network - Predicting the Effects of Various Therapies on Biomarkers (BIOMD0000000611) Using a Systems Pharmacology Model of the Blood Co [...] curated model icon download icon

botulism

Model name Publication Status  
Lebeda2008 - BoNT paralysis (3 step model) (BIOMD0000000267) Onset dynamics of type A botulinum neurotoxin-indu [...] curated model icon download icon
Lebeda2008 - BoTN Paralysis (4 step model) (BIOMD0000000178) Onset dynamics of type A botulinum neurotoxin-indu [...] curated model icon download icon

breast cancer

Model name Publication Status  
Morrison1989 - Folate Cycle (BIOMD0000000018) Folate cycle kinetics in human breast cancer cells [...] curated model icon download icon
Mufudza2012 - Estrogen effect on the dynamics of breast cancer (MODEL1304190001) Assessing the effects of estrogen on the dynamics [...] non-curated model icon download icon

calcium metabolism disease

Model name Publication Status  
Shrestha2010_HyperCalcemia_PTHresponse (BIOMD0000000277) A mathematical model of parathyroid hormone respon [...] curated model icon download icon
Shrestha2010_HypoCalcemia_PTHresponse (BIOMD0000000276) A mathematical model of parathyroid hormone respon [...] curated model icon download icon

cancer

Model name Publication Status  
Capuani2015 - Binding of Cbl and Gbr2 to EGFR (Multisite Phosphorylation Model - MPM) (BIOMD0000000594) Quantitative analysis reveals how EGFR activation [...] curated model icon download icon
Capuani2015 - Binding of Cbl and Grb2 to EGFR (Early Activation Model - EAM) (BIOMD0000000595) Quantitative analysis reveals how EGFR activation [...] curated model icon download icon
Faratian2009 - Role of PTEN in Trastuzumab resistance (BIOMD0000000424) Systems biology reveals new strategies for persona [...] curated model icon download icon
Mosca2012 - Central Carbon Metabolism Regulated by AKT (BIOMD0000000426) Computational modeling of the metabolic States reg [...] curated model icon download icon
Orton2009 - Modelling cancerous mutations in the EGFR/ERK pathway - EGF Model (BIOMD0000000623) Computational modelling of cancerous mutations in [...] curated model icon download icon
Reed2008_Glutathione_Metabolism (BIOMD0000000268) A mathematical model of glutathione metabolism. curated model icon download icon

cardiovascular system disease

Model name Publication Status  
Orfao2008_ThrombinGeneration_AmidolyticActivity (BIOMD0000000366) Qualitative properties and stabilizability of a mo [...] curated model icon download icon
Reed2008_Glutathione_Metabolism (BIOMD0000000268) A mathematical model of glutathione metabolism. curated model icon download icon

cartilage disease

Model name Publication Status  
Proctor2013 - Cartilage breakdown, interventions to reduce collagen release (BIOMD0000000504) A computer simulation approach for assessing thera [...] curated model icon download icon

cataract

Model name Publication Status  
Proctor2005 - Actions of chaperones and their role in ageing (BIOMD0000000091) Modelling the actions of chaperones and their role [...] curated model icon download icon

cerebral degeneration

Model name Publication Status  
Clarke2000 - One-hit model of cell death in neuronal degenerations (BIOMD0000000538) A one-hit model of cell death in inherited neurona [...] curated model icon download icon

cholesterol embolism

Model name Publication Status  
Bucher2011_Atorvastatin_Metabolism (BIOMD0000000328) A systems biology approach to dynamic modeling and [...] curated model icon download icon

cholesterol ester storage disease

Model name Publication Status  
McAuley2012 - Whole-body Cholesterol Metabolism (BIOMD0000000434) A whole-body mathematical model of cholesterol met [...] curated model icon download icon

colorectal cancer

Model name Publication Status  
Kim2007 - Crosstalk between Wnt and ERK pathways (BIOMD0000000149) A hidden oncogenic positive feedback loop caused b [...] curated model icon download icon

coronary artery disease

Model name Publication Status  
Mueller2008_ThrombinGeneration_minimal (BIOMD0000000367) Tolerance and threshold in the extrinsic coagulati [...] curated model icon download icon

diabetes mellitus

Model name Publication Status  
Alvehag2006_IVGTT_GlucoseModel_A (MODEL1112110000) The Feedback Control of Glucose: On the road to ty [...] non-curated model icon download icon
Alvehag2006_OGTT_GlucoseModel_B (MODEL1112110001) The Feedback Control of Glucose: On the road to ty [...] non-curated model icon download icon
Bertram2004_PancreaticBetaCell_modelB (BIOMD0000000373) Calcium and glycolysis mediate multiple bursting m [...] curated model icon download icon
Brannmark2010_InsulinSignalling_Mifamodel (BIOMD0000000343) Mass and information feedbacks through receptor en [...] curated model icon download icon
DallaMan2007_MealModel_GlucoseInsulinSystem (BIOMD0000000379) Meal simulation model of the glucose-insulin syste [...] curated model icon download icon
DeVries2000_PancreaticBetaCells_InsulinSecretion (BIOMD0000000371) Channel sharing in pancreatic beta -cells revisite [...] curated model icon download icon
Ferreira2003_CML_generation2 (BIOMD0000000053) A quantitative model of the generation of N(epsilo [...] curated model icon download icon
Fridlyand2010_GlucoseSensitivity_A (BIOMD0000000348) Glucose sensing in the pancreatic beta cell: a com [...] curated model icon download icon
Fridlyand2010_GlucoseSensitivity_B (BIOMD0000000349) Glucose sensing in the pancreatic beta cell: a com [...] curated model icon download icon
Jiang2007 - GSIS system, Pancreatic Beta Cells (BIOMD0000000239) A kinetic core model of the glucose-stimulated ins [...] curated model icon download icon
Koenig2012_HepaticGlucoseMetabolism (MODEL1209260000) Kinetic modeling of human hepatic glucose metaboli [...] non-curated model icon download icon
Koschorreck2008_InsulinClearance (BIOMD0000000345) Mathematical modeling and analysis of insulin clea [...] curated model icon download icon
Lenbury2001_InsulinKineticsModel_A (MODEL1201140002) Modeling insulin kinetics: responses to a single o [...] non-curated model icon download icon
Lenbury2001_InsulinKineticsModel_B (MODEL1201140003) Modeling insulin kinetics: responses to a single o [...] non-curated model icon download icon
Noguchi2013 - Insulin dependent glucose metabolism (BIOMD0000000482) The selective control of glycolysis, gluconeogenes [...] curated model icon download icon
Nyman2011_M3Hierarachical_InsulinGlucosedynamics (BIOMD0000000356) A hierarchical whole-body modeling approach elucid [...] curated model icon download icon
Sedaghat2002_InsulinSignalling_noFeedback (BIOMD0000000137) A mathematical model of metabolic insulin signalin [...] curated model icon download icon
Smith2013 - Regulation of Insulin Signalling by Oxidative Stress (BIOMD0000000474) Computational modelling of the regulation of Insul [...] curated model icon download icon
Sturis1991_InsulinGlucoseModel_UltradianOscillation (BIOMD0000000382) Computer model for mechanisms underlying ultradian [...] curated model icon download icon
Tolic2000_InsulinGlucoseFeedback (BIOMD0000000372) Modeling the insulin-glucose feedback system: the [...] curated model icon download icon
Topp2000_BetaCellMass_Diabetes (BIOMD0000000341) A model of beta-cell mass, insulin, and glucose ki [...] curated model icon download icon

disease by infectious agent

Model name Publication Status  
Munz2009 - Zombi Impulsive Killing (MODEL1008060000) When Zombies Attack!: Mathematical modelling of an [...] non-curated model icon download icon
Munz2009 - Zombie SIZRC (MODEL1008060001) When Zombies Attack!: Mathematical modelling of an [...] non-curated model icon download icon
Munz2009 - Zombie SIZRQ (MODEL1008060002) When Zombies Attack!: Mathematical modelling of an [...] non-curated model icon download icon
Munz2009 - Zombie basic SZR (MODEL1009230000) When Zombies Attack!: Mathematical modelling of an [...] non-curated model icon download icon

duodenal ulcer

Model name Publication Status  
Leber2016 - Expanded model of Tfh-Tfr differentiation - Helicobacter pylori infection (BIOMD0000000625) Bistability analyses of CD4+ T follicular helper a [...] curated model icon download icon

fatty liver disease

Model name Publication Status  
Tiemann2011_PhenotypeTransitions (MODEL1112150000) Parameter adaptations during phenotype transitions [...] non-curated model icon download icon

glucocorticoid-remediable aldosteronism

Model name Publication Status  
Komarova2005_PTHaction_OsteoclastOsteoblastCoupling (BIOMD0000000279) Mathematical model of paracrine interactions betwe [...] curated model icon download icon
Lemaire2004 - Role of RANK/RANKL/OPG pathway in bone remodelling process (BIOMD0000000278) Modeling the interactions between osteoblast and o [...] curated model icon download icon

heart disease

Model name Publication Status  
Bucher2011_Atorvastatin_Metabolism (BIOMD0000000328) A systems biology approach to dynamic modeling and [...] curated model icon download icon
Saucerman2006_PKA (BIOMD0000000165) Systems analysis of PKA-mediated phosphorylation g [...] curated model icon download icon
Wang2008_Neonatal_heartfunction (MODEL7814665196) Mathematical model of the neonatal mouse ventricul [...] non-curated model icon download icon

hemochromatosis

Model name Publication Status  
Mitchell2013 - Liver Iron Metabolism (BIOMD0000000498) A computational model of liver iron metabolism. curated model icon download icon

hemophilia B

Model name Publication Status  
Wajima2009_BloodCoagulation_PTtest (BIOMD0000000339) A comprehensive model for the humoral coagulation [...] curated model icon download icon
Wajima2009_BloodCoagulation_aPTTtest (BIOMD0000000338) A comprehensive model for the humoral coagulation [...] curated model icon download icon
Wajima2009_BloodCoagulation_warfarin_heparin (BIOMD0000000340) A comprehensive model for the humoral coagulation [...] curated model icon download icon

human immunodeficiency virus infectious disease

Model name Publication Status  
Aguilera 2014 - HIV latency. Interaction between HIV proteins and immune response (BIOMD0000000573) Studying HIV latency by modeling the interaction b [...] curated model icon download icon
Nelson2000_HIV-1_general_model (MODEL8268650277) A model of HIV-1 pathogenesis that includes an int [...] non-curated model icon download icon
Nelson2000_HIV-1_intracellular_delay (MODEL8102792069) A model of HIV-1 pathogenesis that includes an int [...] non-curated model icon download icon

hyperparathyroidism

Model name Publication Status  
Peterson2010 - Integrated calcium homeostasis and bone remodelling (BIOMD0000000613) A physiologically based mathematical model of inte [...] curated model icon download icon

hypersensitivity reaction type II disease

Model name Publication Status  
Alexander2010_Tcell_Regulation_Sys1 (BIOMD0000000289) Self-tolerance and autoimmunity in a regulatory T [...] curated model icon download icon
Alexander2010_Tcell_Regulation_Sys2 (BIOMD0000000290) Self-tolerance and autoimmunity in a regulatory T [...] curated model icon download icon

hypoparathyroidism

Model name Publication Status  
Peterson2010 - Integrated calcium homeostasis and bone remodelling (BIOMD0000000613) A physiologically based mathematical model of inte [...] curated model icon download icon

immune system disease

Model name Publication Status  
Dunster2014 - WBC Interactions (Model1) (BIOMD0000000616) The resolution of inflammation: a mathematical mod [...] curated model icon download icon

influenza

Model name Publication Status  
Fribourg2014 - Dynamics of viral antagonism and innate immune response (H1N1 influenza A virus - NC/99) (BIOMD0000000529) Model of influenza A virus infection: dynamics of [...] curated model icon download icon
Heldt2012 - Influenza Virus Replication (BIOMD0000000463) Modeling the intracellular dynamics of influenza v [...] curated model icon download icon
Miao2010 - Innate and adaptive immune responses to primary Influenza A Virus infection (BIOMD0000000546) Quantifying the early immune response and adaptive [...] curated model icon download icon

inherited blood coagulation disease

Model name Publication Status  
Hockin1999_BloodCoagulation_VaInactivation (BIOMD0000000365) A model describing the inactivation of factor Va b [...] curated model icon download icon

leishmaniasis

Model name Publication Status  
Mandlik2013 - Synthetic circuit of IPC synthase in Leishmania (MODEL1208030000) Synthetic circuit of inositol phosphorylceramide s [...] non-curated model icon download icon
Mandlik2015 - Tristable genetic circuit of Leishmania (BIOMD0000000584) Regulatory dynamics of network architecture and fu [...] curated model icon download icon
Mol2013 - Immune Signal Transduction in Leishmaniasis (BIOMD0000000477) Immune signal transduction in leishmaniasis from n [...] curated model icon download icon
Mol2013 - Leishmania macrophage signaling network (MODEL1203220000) Signaling networks in Leishmania macrophages decip [...] non-curated model icon download icon

liver disease

Model name Publication Status  
Mueller2015 - Hepatocyte proliferation, T160 phosphorylation of CDK2 (BIOMD0000000568) T160-phosphorylated CDK2 defines threshold for HGF [...] curated model icon download icon
Nikolaev2005_AlbuminBilirubinAdsorption (BIOMD0000000291) Mathematical model of binding of albumin-bilirubin [...] curated model icon download icon

lung cancer

Model name Publication Status  
Tham2008 - PDmodel, Tumour shrinkage by gemcitabine and carboplatin (BIOMD0000000234) A pharmacodynamic model for the time course of tum [...] curated model icon download icon

mature T-cell and NK-cell lymphoma

Model name Publication Status  
Raia2010 - IL13 Signalling MedB1 (BIOMD0000000313) Dynamic mathematical modeling of IL13-induced sign [...] curated model icon download icon

multiple myeloma

Model name Publication Status  
Ayati2010_BoneRemodelingDynamics_NormalCondition (BIOMD0000000401) A mathematical model of bone remodeling dynamics f [...] curated model icon download icon
Ayati2010_BoneRemodelingDynamics_WithTumour (BIOMD0000000402) A mathematical model of bone remodeling dynamics f [...] curated model icon download icon
Ayati2010_BoneRemodelingDynamics_WithTumour+DrugTreatment (BIOMD0000000403) A mathematical model of bone remodeling dynamics f [...] curated model icon download icon

neonatal abstinence syndrome

Model name Publication Status  
Yang2006_Methadone_PKmodel (MODEL1006230040) Population-based analysis of methadone distributio [...] non-curated model icon download icon

neurodegenerative disease

Model name Publication Status  
Proctor2007 - Age related decline of proteolysis, ubiquitin-proteome system (BIOMD0000000105) An in silico model of the ubiquitin-proteasome sys [...] curated model icon download icon
Proctor2010 - UCHL1 Protein Aggregation (BIOMD0000000293) Modelling the role of UCH-L1 on protein aggregatio [...] curated model icon download icon
Proctor2011_ProteinHomeostasis_NormalCondition (BIOMD0000000344) Modelling the role of the Hsp70/Hsp90 system in th [...] curated model icon download icon
Tang2010_PolyGlutamate (BIOMD0000000285) Experimental and computational analysis of polyglu [...] curated model icon download icon

non-small cell lung carcinoma

Model name Publication Status  
Bianconi2012 - EGFR and IGF1R pathway in lung cancer (BIOMD0000000427) Computational model of EGFR and IGF1R pathways in [...] curated model icon download icon
Bidkhori2012 - EGFR signalling in NSCLC (BIOMD0000000453) Modeling of tumor progression in NSCLC and intrins [...] curated model icon download icon

ocular albinism

Model name Publication Status  
Clarke2000 - One-hit model of cell death in neuronal degenerations (BIOMD0000000538) A one-hit model of cell death in inherited neurona [...] curated model icon download icon

osteoarthritis

Model name Publication Status  
Benson2014 - FAAH inhibitors for the treatment of osteoarthritic pain (BIOMD0000000512) A systems pharmacology perspective on the clinical [...] curated model icon download icon
Hui2014 - Age-related changes in articular cartilage (BIOMD0000000560) Oxidative changes and signalling pathways are pivo [...] curated model icon download icon
Komarova2003_BoneRemodeling (BIOMD0000000148) Mathematical model predicts a critical role for os [...] curated model icon download icon

osteoporosis

Model name Publication Status  
Komarova2003_BoneRemodeling (BIOMD0000000148) Mathematical model predicts a critical role for os [...] curated model icon download icon

ovarian disease

Model name Publication Status  
Roblitz2013 - Menstrual Cycle following GnRH analogue administration (BIOMD0000000494) A mathematical model of the human menstrual cycle [...] curated model icon download icon
Stötzel2012 - Bovine estrous cycle, synchronization with prostaglandin F2α (BIOMD0000000481) Advances in modeling of the bovine estrous cycle: [...] curated model icon download icon

pancreatic cancer

Model name Publication Status  
Rateitschak2012 - Interferon-gamma (IFN?) induced STAT1 signalling (PC_IFNg100) (BIOMD0000000585) Parameter identifiability and sensitivity analysis [...] curated model icon download icon

peptic ulcer disease

Model name Publication Status  
Leber2016 - Expanded model of Tfh-Tfr differentiation - Helicobacter pylori infection (BIOMD0000000625) Bistability analyses of CD4+ T follicular helper a [...] curated model icon download icon

pertussis

Model name Publication Status  
Restif2006 - Whooping cough (BIOMD0000000249) Integrating life history and cross-immunity into t [...] curated model icon download icon
Restif2007 - Vaccination invasion (BIOMD0000000294) Vaccination and the dynamics of immune evasion. curated model icon download icon

polycythemia due to hypoxia

Model name Publication Status  
Hunziker2010_p53_StressSpecificResponse (BIOMD0000000252) Stress-specific response of the p53-Mdm2 feedback [...] curated model icon download icon
Schmierer2010_FIH_Ankyrins (BIOMD0000000300) Hypoxia-dependent sequestration of an oxygen senso [...] curated model icon download icon

primary bacterial infectious disease

Model name Publication Status  
Kaiser2014 - Salmonella persistence after ciprofloxacin treatment (BIOMD0000000527) Cecum lymph node dendritic cells harbor slow-growi [...] curated model icon download icon

prion disease

Model name Publication Status  
Martins2013 - True and apparent inhibition of amyloid fribril formation (BIOMD0000000561) True and apparent inhibition of amyloid fibril for [...] curated model icon download icon

retinal degeneration

Model name Publication Status  
Clarke2000 - One-hit model of cell death in neuronal degenerations (BIOMD0000000538) A one-hit model of cell death in inherited neurona [...] curated model icon download icon

retinal detachment

Model name Publication Status  
Clarke2000 - One-hit model of cell death in neuronal degenerations (BIOMD0000000538) A one-hit model of cell death in inherited neurona [...] curated model icon download icon

retinal disease

Model name Publication Status  
Clarke2000 - One-hit model of cell death in neuronal degenerations (BIOMD0000000538) A one-hit model of cell death in inherited neurona [...] curated model icon download icon

rheumatoid arthritis

Model name Publication Status  
Baker2013 - Cytokine Mediated Inflammation in Rheumatoid Arthritis (BIOMD0000000550) Mathematical modelling of cytokine-mediated inflam [...] curated model icon download icon
Baker2013 - Cytokine Mediated Inflammation in Rheumatoid Arthritis - Age Dependent (BIOMD0000000549) Mathematical modelling of cytokine-mediated inflam [...] curated model icon download icon

swine influenza

Model name Publication Status  
Fribourg2014 - Dynamics of viral antagonism and innate immune response (H1N1 influenza A virus - Cal/09) (BIOMD0000000528) Model of influenza A virus infection: dynamics of [...] curated model icon download icon

tauopathy

Model name Publication Status  
Yuraszeck2010 - Vulnerabilities in the Tau Network in Tau Pathophysiology (BIOMD0000000542) Vulnerabilities in the tau network and the role of [...] curated model icon download icon

tuberculosis

Model name Publication Status  
Palsson2013 - Fully-integrated immune response model (FIRM) (BIOMD0000000608) The development of a fully-integrated immune respo [...] curated model icon download icon

type 1 diabetes mellitus

Model name Publication Status  
Maree2006_DuCa_Type1DiabetesModel (BIOMD0000000381) Modelling the onset of Type 1 diabetes: can impair [...] curated model icon download icon

type 2 diabetes mellitus

Model name Publication Status  
Brännmark2013 - Insulin signalling in human adipocytes (diabetic condition) (BIOMD0000000449) Insulin signaling in type 2 diabetes: experimental [...] curated model icon download icon
Brännmark2013 - Insulin signalling in human adipocytes (normal condition) (BIOMD0000000448) Insulin signaling in type 2 diabetes: experimental [...] curated model icon download icon
Palmer2014 - Effect of IL-1β-Blocking therapies in T2DM - Disease Condition (BIOMD0000000620) Effects of IL-1β-Blocking Therapies in Type 2 Diab [...] curated model icon download icon
Palmer2014 - Effect of IL-1β-Blocking therapies in T2DM - Healthy Condition (BIOMD0000000621) Effects of IL-1β-Blocking Therapies in Type 2 Diab [...] curated model icon download icon
Silber2007_IntravenousGlucose_IntegratedGlucoseInsulinModel (MODEL1112110004) An integrated model for glucose and insulin regula [...] non-curated model icon download icon

See also: International Classification of Diseases

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