March, 2024
Deciphering cell fate: a mathematical model of life and death decisions in erythroid progenitors
Model(s) associated with this Model of the Month: MODEL2404170002.
Last updated by: Lorenz Adlung
BioModels is a repository of mathematical models of biological and biomedical systems. It hosts a vast selection of existing literature-based physiologically and pharmaceutically relevant mechanistic models in standard formats. Our mission is to provide the systems modelling community with reproducible, high-quality, freely-accessible models published in the scientific literature. More information about using BioModels such as model submission, update, publication, or reviewers access can be found in the FAQ.
March, 2024
Every second you read this (every second of your life), two to three million new red blood cells are produced in your body (1). The key players in the production of red blood cells are called erythroid progenitors. They operate under a tightly regulated network of signalling pathways in which the JAK2/STAT5 axis plays a central role. Our understanding of erythroid progenitors has been primarily at the population level. Still, this perspective fails to capture the intricate cell-to-cell variability fundamental to individual cell fate decisions.
Model(s) associated with this Model of the Month: MODEL2404170002.
Last updated by: Lorenz Adlung
BioModels provides online courses, please consult more information.