May, 2024
Protein synthesis and post-translational modification
Model(s) associated with this Model of the Month: BIOMD0000001078.
Last updated by: Eva-Maria Geissen
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May, 2024
Our model prevents the intuitive misinterpretation of proteomics data by enabling the interpretation of these data in a way that is impossible without a model. When a protein exists in multiple proteoforms, such as when measuring unmodified and modified proteoforms of the same protein, the biological interpretation of pSILAC data becomes non-trivial. We demonstrate that for interconvertible proteoforms, metabolic labelling does not provide direct information on differences in protein stability as previously suggested based on intuition alone. Measured clearance profiles rather tie into the relative order of modifications along the lifetime of a protein, with early modification exhibiting faster clearance than later ones.
Model(s) associated with this Model of the Month: BIOMD0000001078.
Last updated by: Eva-Maria Geissen
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