January, 2024
DeBoeck2021 - Modular approach to modelling the cell cycle
Model(s) associated with this Model of the Month: BIOMD0000001079, BIOMD0000001080.
Last updated by: Jan Rombouts
BioModels is a repository of mathematical models of biological and biomedical systems. It hosts a vast selection of existing literature-based physiologically and pharmaceutically relevant mechanistic models in standard formats. Our mission is to provide the systems modelling community with reproducible, high-quality, freely-accessible models published in the scientific literature. More information about using BioModels such as model submission, update, publication, or reviewers access can be found in the FAQ.
January, 2024
To multiply, a cell goes through a sequence of phases in the cell division cycle. The transitions between these phases are quick and robust due to a so-called bistable switch. Moreover, lowering cyclin B values does not immediately lead to mitotic exit – the threshold for inactivation of Cdk1 is lower than its activation threshold, leading to hysteresis. In our paper, we propose a solution to this problem. We modify a Hill-type ultrasensitive response such that it produces a bistable response. These bistable responses can, just like Hill functions, be included directly in larger models.
Model(s) associated with this Model of the Month: BIOMD0000001079, BIOMD0000001080.
Last updated by: Jan Rombouts
BioModels provides online courses, please consult more information.